Results 51 to 60 of about 848,154 (350)

Interleukin-22 Attenuates Acute Pancreatitis-Associated Intestinal Mucosa Injury in Mice via STAT3 Activation

Gut and Liver, 2021
Background/Aims: Interleukin-22 (IL-22) is an important cytokine maintaining homeostasis at barrier surfaces. In this study, the role of IL-22 in acute pancreatitis-associated intestinal injury was further explored.
Jinxia Bai, Jinyun Bai, Meng Yang
doaj   +1 more source

Restoration of Type 17 immune signaling is not sufficient for protection during influenza-associated pulmonary aspergillosis

Frontiers in Immunology
IntroductionInfluenza-associated pulmonary aspergillosis (IAPA) is a severe complication of influenza infection that occurs in critically ill patients and results in higher mortality compared to influenza infection alone.
Aijaz Ahmad, Ravineel B. Singh, Kara L. Nickolich, Matthew J. Pilewski, Caden Ngeow, Kwame Frempong-Manso, Keven M. Robinson   +6 more
doaj   +1 more source

Tissue Cytokine Responses in Canine Visceral Leishmaniasis [PDF]

, 2001
To elucidate the local tissue cytokine response of dogs infected with Leishmania chagasi, cytokine mRNA levels were measured in bone marrow aspirates from 27 naturally infected dogs from Brazil and were compared with those from 5 uninfected control ...
Courtenay, O., Day, M.J., Dye, C., Garcez, L.M., Kaye, P.M., Quinnell, R.J., Shaw, M.-A.   +6 more
core   +2 more sources

Biological and pathological activities of interleukin-22 [PDF]

Journal of Molecular Medicine, 2016
Interleukin (IL)-22, a member of the IL-10 family, is a cytokine secreted by several types of immune cells including IL-22(+)CD4(+) T cells (Th22) and IL-22 expressing innate leukocytes (ILC22). Recent studies have demonstrated that IL-22 is a key component in mucosal barrier defense, tissue repair, epithelial cell survival, and proliferation ...
Mirna, Perusina Lanfranca, Yanwei, Lin, Jingyuan, Fang, Weiping, Zou, Timothy, Frankel   +4 more
openaire   +2 more sources

Analysis of Interleukin 22 Gene Expression in Helicobacter pylori-Infected Patients With Inflammation and Peptic Ulcer Compared to Uninfected Controls [PDF]

Journal of Shahrekord University of Medical Sciences
Background and aims: Inflammation is a key feature of Helicobacter pylori infection and its associated complications, gastritis, and gastrointestinal ulcers.
Mehrnoosh Haghighian, Noosha Zia Jahromi, Ghorbanali Rahimian   +2 more
doaj   +1 more source

Pivotal Role of IL-22 Binding Protein in the Epithelial Autoregulation of Interleukin-22 Signaling in the Control of Skin Inflammation

Frontiers in Immunology, 2018
Disruption of skin homeostasis can lead to inflammatory cutaneous diseases resulting from the dysregulated interplay between epithelial keratinocytes and immune cells.
Tomohiro Fukaya, Tomohiro Fukaya, Takehito Fukui, Takehito Fukui, Tomofumi Uto, Tomofumi Uto, Hideaki Takagi, Hideaki Takagi, Junta Nasu, Junta Nasu, Noriaki Miyanaga, Noriaki Miyanaga, Keiichi Arimura, Keiichi Arimura, Takeshi Nakamura, Takeshi Nakamura, Haruhiko Koseki, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato, Katsuaki Sato   +20 more
doaj   +1 more source

Decreased Serum Level of Interleukin-22 Correlates with Hepcidin in Patients with Hidradenitis Suppurativa

Acta Dermato-Venereologica, 2021
Current understanding of the underlying pathophysiology of hidradenitis suppurativa (HS) links the disease with proinflammatory activation and autoimmune processes.
Malgorzata Ponikowska, Łukasz Matusiak, Monika Kasztura, Ewa Jankowska, Jacek C. Szepietowski   +4 more
doaj   +1 more source

Interleukin-22 in alcoholic hepatitis and beyond

Hepatology International, 2020
Alcoholic hepatitis (AH) is a clinical syndrome characterized by jaundice and progressive inflammatory liver injury in patients with a history of prolonged periods of excess alcohol consumption and recent heavy alcohol abuse. Severe AH is a life-threatening form of alcohol-associated liver disease with a high short-term mortality rate around 30-50% at ...
Xiaogang, Xiang, Seonghwan, Hwang, Dechun, Feng, Vijay H, Shah, Bin, Gao   +4 more
openaire   +3 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Evaluation of the Effect of Empagliflozin Therapy on T Helper 22 Cell-Related Factors in Patients with Type 2 Diabetes Mellitus

پزشکی بالینی ابن سینا, 2021
Background and Objective:The increased response of T helper (Th) 22cells might be involved in thepathogenesis ofType 2 Diabetes Mellitus (T2DM). The present study aimed to investigate the transcription factor of Th22 cells (aryl hydrocarbon receptor [AHR]
Hamid Moghimi, Shiva Borzouei, Alireza Zamani, Mahdi Behzad   +3 more
doaj