Results 51 to 60 of about 60,800,054 (257)

Interleukin-22 and its crystal structure

, 2006
Interleukin-22 (IL-22) is a cytokine that regulates the production of acute phase proteins of the immunological response. On binding to its cognate receptor (IL-22R1), which is associated to the interleukin-10 receptor 2 (IL-10R2), IL-22 promotes ...
Ferreira Junior, Josii Ribamar, Laure Dumoutier, Jean‐Christophe Renauld, Ronaldo Alves Pinto Nagem, José Ribamar Ferreira Júnior, Igor Polikarpov, Pinto Nagem, Ronaldo Alves, Polikarpov, Igor, Dumoutier, Laure, Renauld, Jean-Christophe   +9 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis [PDF]

, 2011
To study the role of interleukin 22 (IL-22) in rheumatoid arthritis (RA)
Dechant, Claudia, Schramm, Markus A., Grunke, Mathias, Baeuerle, Michael, Schulze-Koops, Hendrik, Leipe, Jan, Reindl, Christiane S., Nigg, Axel P., Vielhauer, Volker, Skapenko, Alla, Witt, Matthias N., C. Dechant, M. Grunke, J. Leipe, M. N. Witt, A. Skapenko, C. S. Reindl, V. Vielhauer, M. A. Schramm, H. Schulze-Koops, M. Baeuerle, A. P. Nigg   +21 more
core   +1 more source

Reprogramming Intestinal Epithelial Cell Polarity by Interleukin-22

Frontiers in Medicine, 2021
Background: Interleukin-22 (IL-22) impacts the integrity of intestinal epithelia and has been associated with the development of colitis-associated cancer and inflammatory bowel diseases (IBD).
Deborah Delbue, Lydia Lebenheim, Danielle Cardoso-Silva, Violaine Dony, Susanne M. Krug, Jan F. Richter, Subhakankha Manna, Melba Muñoz, Melba Muñoz, Kerstin Wolk, Kerstin Wolk, Claudia Heldt, Markus M. Heimesaat, Robert Sabat, Robert Sabat, Britta Siegmund, Michael Schumann   +16 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Truncated Chicken Interleukin-1β with Increased Biologic Activity [PDF]

, 2003
Chicken interleukin-1β (ChIL-1β) is synthesized as a precursor molecule that unlike its mammalian counterpart, lacks a typical caspase-1 cleavage site. Therefore, it was unclear if proteolytic cleavage of ChIL-1β can occur and if cleavage might modulate ...
Erno Duda, Zsuzsa Gyorfy, Duda, Erno, Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Annette Ohnemus, Kaspers, Bernd, Gyorfy, Zsuzsa, Ohnemus, Annette, Bernd Kaspers   +10 more
core   +1 more source

The Effect of Conventional Immunosuppressive Therapy on Cytokine Serum Levels in Pemphigus Vulgaris Patients

Iranian Journal of Allergy, Asthma and Immunology, 2014
Pemphigus vulgaris is an autoimmune disease, in which the role of Th17 cytokines needs to be further explored. This study was performed to assess serum levels of three interleukins (IL) required for Th17 differentiation (IL-1β, IL-6 and IL-23) and two ...
Hossein Mortazavi, Nafiseh Esmaili, Somayeh Khezri, Ali Khamesipour, Iman Vasheghani Farahani, Maryam Daneshpazhooh, Nima Rezaei   +6 more
doaj  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source