Results 151 to 160 of about 63,478,598 (186)

Interleukin-35: The Future of Hyperimmune-Related Diseases?

Journal of Interferon & Cytokine Research, 2013
Interleukin (IL-35) is a newly identified heterodimeric cytokine belonging to the IL-12 family. It contains Epstein-Barr virus-induced gene 3 subunit and IL-27 p35 subunit. Although its receptor and signaling pathway are not clear, we presumed that its receptor is composed by two chains that might be similar to those receptors of IL-12, IL-23, and IL ...
Sunyi, Ye, Jian, Wu, Lin, Zhou, Zhen, Lv, Haiyang, Xie, Shusen, Zheng   +5 more
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[35] Human interleukin 1

1985
Publisher Summary This chapter provides an overview of human interleukin 1. Interleukin 1 (IL- 1), formerly designated “lymphocyte activating factor,” is a cytokine which was strictly defined to be produced by mononuclear phagocytes and to stimulate T lymphocytes. Two fractions of human white blood cells are being used in our laboratories as a source
Igal Gery, John A. Schmidt
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Interleukin-35: An emerging player in the progression of liver diseases

Clinics and Research in Hepatology and Gastroenterology, 2021
Interleukin-35(IL-35), a newly identified immunosuppressive cytokine, has recently been shown to play a significant role in the progression of various autoimmune diseases and malignant tumors. The liver is the largest organ in the body and is generally regarded as an important lymphoid organ by an increasing number of immunologists. A number of reports
Na, Zhao, Xin, Liu, Hao, Guo, Xiangnan, Zhao, Yujie, Qiu, Wei, Wang   +5 more
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INTERLEUKIN-35 IN IDIOPATHIC INFLAMMATORY MYOPATHIES

ANNALS OF THE RHEUMATIC DISEASES, 2016
Background Interleukin-35 (IL-35) is a newly described heterodimeric cytokine that belongs to the IL-12 family and consists of p35 (IL-12a) and EBI3 (IL-27b) subunits. IL-35 exerts immunomodulatory activities in several autoimmune inflammatory diseases. Objectives The aim of this study was to assess IL-35 expression in muscle tissue of patients with
Mann, H.; Krystufkova, O.; Hulejova, H.; Zamecnik, J.; Hacek, J.; Filkova, M.; Vencovsky, J.; Senolt, L.   +8 more
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Interleukin-35: A Serological Biomarker for Patients with Polymyositis/Dermatomyositis

Journal of Interferon & Cytokine Research, 2019
Interleukin (IL)-35 is confirmed as an important modulator in immune response. The aim of the study was to explore the role of IL-35 in the development of polymyositis/dermatomyositis (PM/DM). Ninety-five patients with PM/DM and 30 healthy controls (HCs) were recruited.
Qinglai, Jiang, Yuxuan, Li, Liping, Xia, Hui, Shen, Jing, Lu   +4 more
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Interleukin-35: a Potential Therapeutic Agent for Autoimmune Diseases

Inflammation, 2016
Autoimmune diseases contain a large number of pathologies characterized by various factors that contribute to a breakdown in self-tolerance. Cytokine-mediated immunity plays an essential role in the pathogenesis of varieties of autoimmune diseases.
Shi-Yang, Guan, Rui-Xue, Leng, Muhammad Imran, Khan, Humera, Qureshi, Xiang-Pei, Li, Dong-Qing, Ye, Hai-Feng, Pan   +6 more
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Pro-inflammatory effects of interleukin-35 in rheumatoid arthritis

Cytokine, 2015
Interleukin-35 (IL-35) is a heterodimeric member of the IL-12 family consisting of p35/IL-12a and EBI3/IL-27b subunits. Expressed in murine Treg cells, IL-35 controls inflammatory diseases in mouse models. However, human IL-35 is expressed in Teff cells rather than in Treg cells and is shown to be upregulated under inflammatory conditions.
Mária, Filková, Zdenka, Vernerová, Hana, Hulejová, Klára, Prajzlerová, David, Veigl, Karel, Pavelka, Jiří, Vencovský, Ladislav, Šenolt   +7 more
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Analysis of serum interleukin-27 and interleukin-35 concentrations in patients with Guillain-Barré syndrome

Clinica Chimica Acta, 2017
Guillain-Barré syndrome (GBS) is a postinfectious immune-mediated peripheral neuropathy. Interleukin (IL)-27 and IL-35 have been recognized as novel members of IL-12 family. We evaluated the serum and cerebral spinal fluid (CFS) concentrations of IL-27 and IL-35 in GBS and analyze their correlations with clinical characteristics.Serum samples from 50 ...
Lin-Jie, Zhang, Hui-Yue, Guo, Da-Qi, Zhang, Rong, Wang, Ting, Li, Li-Min, Li, Dong-Mei, Suo, Li, Yang   +7 more
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Levels of Interleukin 27 and Interleukin 35 in the Serum and Vitreous of Patients with Proliferative Diabetic Retinopathy

Ocular Immunology and Inflammation, 2016
To examine the role of interleukin 27(IL-27) and interleukin 35 (IL-35) in diabetic retinopathy (DR).Patients with diabetes mellitus were divided into three groups: diabetes without retinopathy (DWR), non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR).
Ai Yan, Hui You, Xuedong Zhang
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[Preparation of monoclonal antibodies against human interleukin-35 and their application in a quantitative ELISA for interleukin-35 detection].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2019
To establish a quantitative ELISA for human interleukin-35 (IL-35) detection, we cloned cDNAs encoding the 2 subunits IL-27EBI3 and IL-12p35 of IL-35 by RT-PCR and transformed the cDNAs into Escherichia coli BL21 star (DE3) by recombinant DNA technology.
Fengrong, He, Ying, Sun, Xin, Yue, Yong, Liu, Mengyuan, Liu   +4 more
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