Results 201 to 210 of about 176,830 (333)

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity. [PDF]

Mol Autism
Liiwand M, Haikonen J, Kokinovic B, Molchanova SM, Aitta-Aho T, Lauri SE, Ryazantseva M.   +6 more
europepmc   +1 more source

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

Nature Reviews Neuroscience, 2008
G. Ascoli, L. Alonso-Nanclares, S. Anderson, G. Barrionuevo, R. Benavides-Piccione, A. Burkhalter, G. Buzsáki, B. Cauli, J. DeFelipe, A. Fairén, D. Feldmeyer, G. Fishell, Y. Frégnac, T. Freund, D. Gardner, E. P. Gardner, J. Goldberg, M. Helmstaedter, S. Hestrin, F. Karube, Z. Kisvárday, B. Lambolez, D. A. Lewis, O. Marín, H. Markram, A. Muñoz, Adam Packer, C. Petersen, K. Rockland, J. Rossier, B. Rudy, P. Somogyi, J. Staiger, G. Tamás, A. Thomson, Maria Toledo-Rodriguez, Yun Wang, D. C. West, R. Yuste   +38 more
semanticscholar   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Evolutionary neuroeconomic adaptations of fast-spiking neurons in the human neocortex. [PDF]

Front Synaptic Neurosci
Szegedi V, Douida A, Hutóczki G, Novák L, Lamsa K.   +4 more
europepmc   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Inhibitory GABAergic Neuron Loss due to Oxidative Damage During Ex Vivo Acute Brain Slice Preparation Influences Genesis and Dynamics of Epileptiform Activity. [PDF]

J Neurochem
Chan F, Hazra A, Jayasekera A, Huang K, Whyte S, Telford-Cooke L, Lakhani K, Li X, Shields R, Kosim A, Su D, Murray C, Cunningham MO.   +12 more
europepmc   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Psychedelic Modulation of Excitation/Inhibition Balance: A Dual-Phase Neurodevelopmental Model. [PDF]

ACS Chem Neurosci
Kandilakis CL, Papatheodoropoulos C.
europepmc   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source