Opioids excite dopamine neurons by hyperpolarization of local interneurons
Journal of Neuroscience, 1992 Increased activity of dopamine-containing neurons in the ventral tegmental area is necessary for the reinforcing effects of opioids and other abused drugs.
S. Johnson, R. North
semanticscholar +1 more source
Simulating Effects of Learning and Lesions with a Model of Intrinsic and Synaptically Gated Responses of Striatal Cholinergic Interneurons [PDF]
, 2006 The giant cholinergic interneurons of the striatum are tonically active neurons (TANs) that respond with characteristic pauses to novel events and to appetitive and aversive conditioned stimuli.
Bullock, Daniel, Tan, Can Ozan
core +1 more source
Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. [PDF]
, 2016 Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult ...
Ahrens, Eric T +14 more
core +3 more sources
Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors
Advanced Science, EarlyView.Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon +10 more
wiley +1 more source
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders
Frontiers in Molecular Neuroscience, 2018 Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that PV cells and PNN are impaired in a variety of neurological disorders.
Teresa H. Wen +6 more
doaj +1 more source
Heterogeneity and Diversity of Striatal GABAergic Interneurons: Update 2018
Frontiers in Neuroanatomy, 2018 Our original review, “Heterogeneity and Diversity of Striatal GABAergic Interneurons,” to which this is an invited update, was published in December, 2010 in Frontiers is Neuroanatomy. In that article, we reviewed several decades’ worth of anatomical and
J. Tepper +5 more
semanticscholar +1 more source
Development in a biologically inspired spinal neural network for movement control [PDF]
, 1997 In two phases, we develop neural network models of spinal circuitry which self-organises into networks with opponent channels for the control of an antagonistic muscle pair.
Bullock, D. +2 more
core +2 more sources
Advanced Science, EarlyView.Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren +9 more
wiley +1 more source
The gamma rhythm as a guardian of brain health
eLifeGamma oscillations in brain activity (30–150 Hz) have been studied for over 80 years. Although in the past three decades significant progress has been made to try to understand their functional role, a definitive answer regarding their causal implication
Ana Maria Ichim +7 more
doaj +1 more source
Fear Learning Regulates Cortical Sensory Representations by Suppressing Habituation
Frontiers in Neural Circuits, 2018 Projections from auditory cortex to the amygdala are thought to contribute to the induction of auditory fear learning. In addition, fear conditioning has been found to enhance cortical responses to conditioned tones, suggesting that cortical plasticity ...
Shea N. Gillet +5 more
doaj +1 more source