Results 51 to 60 of about 118,802 (309)

Selected issues of GABA metabolism and its potential role in neuropsychiatric disorders.

Journal of Medical Science, 2017
This mini review is limited to chosen problems about GABA metabolism mainly in aspect of associated disorders. GABA primarily identified as inhibitory neurotransmitter plays also excitatory function.
Andrzej Kostyrko
doaj   +1 more source

Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers

BMC Biology, 2020
Abnormal accumulation of amyloid β1–42 oligomers (AβO1–42), a hallmark of Alzheimer’s disease, impairs hippocampal theta-nested gamma oscillations and long-term potentiation (LTP) that are believed to underlie learning and memory.
Kyerl Park, Jaedong Lee, H. Jang, B. Richards, M. Kohl, J. Kwag   +5 more
semanticscholar   +1 more source

Sex differences in the distribution and density of regulatory interneurons in the striatum

Frontiers in Cellular Neuroscience
IntroductionDysfunction of the cortico-basal circuitry – including its primary input nucleus, the striatum – contributes to neuropsychiatric disorders, such as autism and Tourette Syndrome (TS).
Meghan Van Zandt, Deirdre Flanagan, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger   +6 more
doaj   +1 more source

Synaptic plasticity facilitates oscillations in a V1 cortical column model with multiple interneuron types

Frontiers in Computational Neuroscience
Neural rhythms are ubiquitous in cortical recordings, but it is unclear whether they emerge due to the basic structure of cortical microcircuits or depend on function.
Giulia Moreni, Licheng Zou, Cyriel M. A. Pennartz, Cyriel M. A. Pennartz, Jorge F. Mejias, Jorge F. Mejias   +5 more
doaj   +1 more source

Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies

eLife, 2019
Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing.
Jonathan H Cornford, Marion S Mercier, Marco Leite, Vincent Magloire, Michael Häusser, Dimitri M Kullmann   +5 more
doaj   +1 more source

Adaptive disinhibitory gating by VIP interneurons permits associative learning

Nature Neuroscience, 2019
Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during associative learning has been extensively studied, little is known about the contributions of local interneurons.
S. Krabbe, Enrica Paradiso, Simon d’Aquin, Y. Bitterman, J. Courtin, Chun Xu, Keisuke Yonehara, Milica Marković, C. Müller, Tobias Eichlisberger, Jan Gründemann, F. Ferraguti, A. Lüthi   +12 more
semanticscholar   +1 more source

GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex

Frontiers in Cellular Neuroscience, 2023
Extrasynaptic GABAA receptors (GABAARs) mediating tonic inhibition are thought to play an important role in the regulation of neuronal excitability. However, little is known about a cell type-specific tonic inhibition in molecularly distinctive types of ...
Karolina Bogaj, Roksana Kaplon, Joanna Urban-Ciecko   +2 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Directed and efficient generation of calretinin interneurons from human pluripotent stem cells

Stem Cell Research & Therapy
Background Schizophrenia, autism, and epilepsy are associated with dysfunctions in cortical GABAergic interneurons. Calretinin-expressing interneurons, the most prominent type, constitute approximately 50% of human cortical GABAergic neurons and are ...
Xuewei Du, Renli Qi, Congge Li, Wenpei Zhou, Shijiao Wang, Shenxing Wei, Runzhong Wu, Yu Yin, Tianqing Li, Xiaoqing Zhu   +9 more
doaj   +1 more source

Olfactory deficits in aging and Alzheimer’s—spotlight on inhibitory interneurons

Frontiers in Neuroscience
Cognitive function in healthy aging and neurodegenerative diseases like Alzheimer’s disease (AD) correlates to olfactory performance. Aging and disease progression both show marked olfactory deficits in humans and rodents.
Kaoutar Elhabbari, Siran Sireci, Markus Rothermel, Daniela Brunert   +3 more
doaj   +1 more source