Results 41 to 50 of about 146,748 (304)

Sex differences in the distribution and density of regulatory interneurons in the striatum

Frontiers in Cellular Neuroscience
IntroductionDysfunction of the cortico-basal circuitry – including its primary input nucleus, the striatum – contributes to neuropsychiatric disorders, such as autism and Tourette Syndrome (TS).
Meghan Van Zandt, Deirdre Flanagan, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger   +6 more
doaj   +1 more source

Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations [PDF]

, 2003
Electrical coupling between pyramidal cell axons, and between interneuron dendrites, have both been described in the hippocampus. What are the functional roles of the two types of coupling?
Bibbig, A., Buhl, E.H., Hormuzdi, S.G., LeBeau, F.E.N., Monyer, H., Pais, I., Traub, R.D., Whittington, M.A.   +7 more
core   +2 more sources

Synaptic plasticity facilitates oscillations in a V1 cortical column model with multiple interneuron types

Frontiers in Computational Neuroscience
Neural rhythms are ubiquitous in cortical recordings, but it is unclear whether they emerge due to the basic structure of cortical microcircuits or depend on function.
Giulia Moreni, Licheng Zou, Cyriel M. A. Pennartz, Cyriel M. A. Pennartz, Jorge F. Mejias, Jorge F. Mejias   +5 more
doaj   +1 more source

Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies

eLife, 2019
Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing.
Jonathan H Cornford, Marion S Mercier, Marco Leite, Vincent Magloire, Michael Häusser, Dimitri M Kullmann   +5 more
doaj   +1 more source

GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex

Frontiers in Cellular Neuroscience, 2023
Extrasynaptic GABAA receptors (GABAARs) mediating tonic inhibition are thought to play an important role in the regulation of neuronal excitability. However, little is known about a cell type-specific tonic inhibition in molecularly distinctive types of ...
Karolina Bogaj, Roksana Kaplon, Joanna Urban-Ciecko   +2 more
doaj   +1 more source

Comparison Between Supervised and Unsupervised Classifications of Neuronal Cell Types: A Case Study

, 2010
In the study of neural circuits, it becomes essential to discern the different neuronal cell types that build the circuit. Traditionally, neuronal cell types have been classified using qualitative descriptors.
Bielza, Concha, Guerra, Luis, Larrañaga Múgica, Pedro, McGarry, Laura M., Robles Forcada, Víctor, Yuste, Rafael   +5 more
core   +2 more sources

The cellular and synaptic architecture of the mechanosensory dorsal horn [PDF]

, 2017
The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR ...
Abraira, Alexis A. Toliver, Amanda L. Zimmerman, Anda M. Chirila, Andersen, Bai, Bourane, Bryan J. Song, Burgess, Casale, Connie Tsan, Coutaud, Dani, David D. Ginty, David I. Hughes, Du Beau, Emily D. Kuehn, Ferreira, Garcia-Segura, Gjerstad, Gong, Gorski, Graham, Graham, Grudt, Gutierrez-Mecinas, Hasegawa, Horch, Hughes, Ippolito, Jessica Hoynoski, Johnson, Justin Zhuo, Kaiser, Karleena A. Bashista, Kieran A. Boyle, Kim, Laing, Laura Kus, Lauren L. Orefice, Laurent, Li, Ling Bai, Liu, Liu, Lorenzo, Luo, Mark W. Springel, Masahiko Watanabe, Masland, Michael Rutlin, Nakatsuka, Nathaniel Heintz, Niederkofler, Olausson, Orefice, Otazu, Owens, Punnakkal, Rajković, Ralston, Rozell, Rustioni, Rutlin, Sacha B. Nelson, Saunders, Seal, Sieber, Susan M. Dymecki, Tamamaki, Taniguchi, Thomas G. O'Neill, Todd, Todd, Torsney, Uesaka, Valtschanoff, Vera Niederkofler, Victoria E. Abraira, Yasaka, Zimmerman   +80 more
core   +1 more source

The Interneuron Class Struggle [PDF]

Cell, 2020
In this issue of Cell, Gouwens et al. establish the state of the art for defining inhibitory cell types in the mouse neocortex. By combining morphological, electrophysiological, and transcriptomic features to classify interneurons in the mouse visual cortex, this work provides a roadmap for understanding the diversity of cell types and their functional
Jacob M, Ratliff, Renata, Batista-Brito
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Directed and efficient generation of calretinin interneurons from human pluripotent stem cells

Stem Cell Research & Therapy
Background Schizophrenia, autism, and epilepsy are associated with dysfunctions in cortical GABAergic interneurons. Calretinin-expressing interneurons, the most prominent type, constitute approximately 50% of human cortical GABAergic neurons and are ...
Xuewei Du, Renli Qi, Congge Li, Wenpei Zhou, Shijiao Wang, Shenxing Wei, Runzhong Wu, Yu Yin, Tianqing Li, Xiaoqing Zhu   +9 more
doaj   +1 more source