Results 41 to 50 of about 118,802 (309)
Developmental diversification of cortical inhibitory interneurons
Nature, 2017 Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To investigate how this diversity is generated, here we used single-cell RNA sequencing to profile the transcriptomes of mouse cells collected along a ...
Christian Mayer +9 more
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GABAergic interneurons excite neonatal hippocampus in vivo
Science Advances, 2020 During development, the brain’s “inhibitory” neurons act in a diverse manner, exciting hippocampus but inhibiting sensory cortex. GABAergic interneurons are proposed to be critical for early activity and synapse formation by directly exciting, rather ...
Yasunobu Murata, M. Colonnese
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Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia
Frontiers in Behavioral Neuroscience, 2019 Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cognitive
Alexei M. Bygrave +6 more
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Frontiers in Cell and Developmental Biology, 2020 Neural stem cells in the lateral ganglionic eminence (LGE) generate progenitors that migrate through the rostral migratory stream (RMS) to repopulate olfactory bulb (OB) interneurons, but the regulation of this process is poorly defined.
Christopher A. Blackwood +6 more
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Prefrontal somatostatin interneurons encode fear memory
Nature Neuroscience, 2019 Theories stipulate that memories are encoded within networks of cortical projection neurons. Conversely, GABAergic interneurons are thought to function primarily to inhibit projection neurons and thereby impose network gain control, an important but ...
Kirstie A. Cummings, Roger L. Clem
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Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions
Frontiers in Physiology, 2018 Systematic research on the physiological and anatomical characteristics of spinal cord interneurons along with their functional output has evolved for more than one century.
Marie-Pascale Côté +4 more
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Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons
Frontiers in Psychiatry, 2023 The muscarinic acetylcholine receptor (mAChR) antagonist, scopolamine, has been shown to have a rapid antidepressant effect. And it is believed that GABAergic interneurons play a crucial role in this action.
Huanxin Chen +14 more
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Structural Changes Observed in the Piriform Cortex in a Rat Model of Pre-motor Parkinson’s Disease
Frontiers in Cellular Neuroscience, 2018 Early diagnosis of Parkinson’s disease (PD) offers perhaps, the most promising route to a successful clinical intervention, and the use of an animal model exhibiting symptoms comparable to those observed in PD patients in the early stage of the disease ...
Marco Sancandi +4 more
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Cortical gamma band synchronization through somatostatin interneurons
Nature Neuroscience, 2017 Gamma band rhythms may synchronize distributed cell assemblies to facilitate information transfer within and across brain areas, yet their underlying mechanisms remain hotly debated.
Julia Veit +4 more
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The Interneuron Class Struggle [PDF]
Cell, 2020 In this issue of Cell, Gouwens et al. establish the state of the art for defining inhibitory cell types in the mouse neocortex. By combining morphological, electrophysiological, and transcriptomic features to classify interneurons in the mouse visual cortex, this work provides a roadmap for understanding the diversity of cell types and their functional
Jacob M, Ratliff, Renata, Batista-Brito
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