Results 41 to 50 of about 82,209 (267)

Fear Learning Regulates Cortical Sensory Representations by Suppressing Habituation

Frontiers in Neural Circuits, 2018
Projections from auditory cortex to the amygdala are thought to contribute to the induction of auditory fear learning. In addition, fear conditioning has been found to enhance cortical responses to conditioned tones, suggesting that cortical plasticity ...
Shea N. Gillet, Shea N. Gillet, Hiroyuki K. Kato, Marissa A. Justen, Mandy Lai, Jeffry S. Isaacson   +5 more
doaj   +1 more source

The impact of early life maternal deprivation on the perineuronal nets in the prefrontal cortex and hippocampus of young adult rats

Frontiers in Cell and Developmental Biology, 2022
Early life stress negatively impacts brain development and affects structure and function of parvalbumin immunopositive (PV+) inhibitory neurons. Main regulators of PV+ interneurons activity and plasticity are perineuronal nets (PNNs), an extracellular ...
Ana Jakovljevic, Gorana Agatonovic, Dubravka Aleksic, Milan Aksic, Gebhard Reiss, Eckart Förster, Antonios Stamatakis, Igor Jakovcevski, Joko Poleksic   +8 more
doaj   +1 more source

Development of Cortical Interneurons [PDF]

Neuropsychopharmacology, 2014
Inhibitory local circuit neurons (LCNs), often called interneurons, have vital roles in the development and function of cortical networks. Their inhibitory influences regulate both the excitability of cortical projection neurons on the level of individual cells, and the synchronous activity of projection neuron ensembles that appear to be a neural ...
Jianhua, Chu, Stewart A, Anderson
openaire   +2 more sources

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Dysmaturation of Somatostatin Interneurons Following Umbilical Cord Occlusion in Preterm Fetal Sheep

Frontiers in Physiology, 2019
IntroductionCerebral white matter injury is the most common neuropathology observed in preterm infants. However, there is increasing evidence that gray matter development also contributes to neurodevelopmental abnormalities.
Maryam Ardalan, Pernilla Svedin, Ana A. Baburamani, Veena G. Supramaniam, Joakim Ek, Henrik Hagberg, Henrik Hagberg, Carina Mallard   +7 more
doaj   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Multiscale Circuit Architecture Associated With Memory Dysfunction in Temporal Lobe Epilepsy

Advanced Science, EarlyView.
A multiscale precision‐mapping framework reveals that memory impairment in temporal lobe epilepsy arises from the convergence of focal medial temporal pathology, strategic white matter disconnection, and limbic‐centered metabolic network dysfunction.
Jiajie Mo, Qiwen Yuan, Pengfei Zhang, Lin Sang, Zhong Zheng, Baotian Zhao, Xiu Wang, Chao Zhang, Wenhan Hu, Xiaoqiu Shao, Jianguo Zhang, Ruijin Yang, Kai Zhang   +12 more
wiley   +1 more source

Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders

Frontiers in Cellular Neuroscience, 2023
In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder ...
Mònica Pardo, Mònica Pardo, Sara Gregorio, Sara Gregorio, Enrica Montalban, Lluís Pujadas, Lluís Pujadas, Lluís Pujadas, Lluís Pujadas, Alba Elias-Tersa, Alba Elias-Tersa, Núria Masachs, Núria Masachs, Alba Vílchez-Acosta, Alba Vílchez-Acosta, Annabelle Parent, Carme Auladell, Carme Auladell, Jean-Antoine Girault, Miquel Vila, Miquel Vila, Miquel Vila, Miquel Vila, Miquel Vila, Angus C. Nairn, Yasmina Manso, Yasmina Manso, Eduardo Soriano, Eduardo Soriano   +28 more
doaj   +1 more source

Interneurons Brainstem of the Human

Annals of the Russian academy of medical sciences, 2015
Objective: To conduct a comparative study of the structural organization of internuclear interneurons involved in the metabolism of nitrogen monoxide, hydrogen sulphide and carbon monoxide in the caudal brain stem humans.Methods: The cross-sectional study was performed.
V M, Chertok, A E, Kotsyuba, M S, Startseva   +2 more
openaire   +3 more sources

scTIDE: Deciphering Critical Transitions Through Cell‐Perturbed Manifold Graphs and Optimal Transport Conditional Flow Matching

Advanced Science, EarlyView.
scTIDE identifies single‐cell tipping points by combining manifold‐based graph representations with optimal‐transport conditional flow matching, which preserves intrinsic topology and models distributional dynamics. It supports critical‐transition detection at individual‐cell resolution, prediction of unseen cells, and dimensionality reduction and ...
Jiayuan Zhong, Bowen Niu, Yongbo Yu, Shiyang Nie, Xuerong Gu, Pei Chen, Rui Liu   +6 more
wiley   +1 more source