Results 41 to 50 of about 83,755 (215)

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Effect of transcutaneous electrical spinal cord stimulation on the functional activity of reciprocal and presynaptic inhibition in healthy subjects

Russian Open Medical Journal, 2022
The objective of our research was to examine an effect of 20-minute electrical stimulation session of the spinal cord (tESCS) on the manifestation of reciprocal and presynaptic inhibition in the system of shin antagonist muscles in healthy individuals in
Denis A. Gladchenko, Lyudmila V. Roshchina, Sergey M. Bogdanov, Andrey A. Chelnokov   +3 more
doaj   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Abstract Representation of Movement Parameters in Basal Ganglia Output

Advanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero, Diana I. Ortega‐Romero, Claudia I. Pérez‐Díaz, Pavel E. Rueda‐Orozco   +3 more
wiley   +1 more source

A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication

Frontiers in Integrative Neuroscience, 2017
Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity.
Heleen M. van 't Spijker, Jessica C. F. Kwok, Jessica C. F. Kwok   +2 more
doaj   +1 more source

Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits

eLife, 2020
The assembly of specific neuronal circuits relies on the expression of complementary molecular programs in presynaptic and postsynaptic neurons. In the cerebral cortex, the tyrosine kinase receptor ErbB4 is critical for the wiring of specific populations
David Exposito-Alonso, Catarina Osório, Clémence Bernard, Sandra Pascual-García, Isabel del Pino, Oscar Marín, Beatriz Rico   +6 more
doaj   +1 more source

Translatome of dorsal striatum parvalbumin interneurons revisited: insights across diverse experimental paradigms

Frontiers in Cellular Neuroscience
Parvalbumin (PV) interneurons in the dorsal striatum (DS) are fast-spiking GABAergic cells critical for feedforward inhibition and synaptic integration within basal ganglia circuits.
Claire Naon, Laia Castell, Steeve Thirard, Maria Moreno, Stéphanie Rialle, Eva Goetz, Eloi Casals, Eloi Casals, Angelina Rogliardo, Marta Gut, Marta Gut, Anna Esteve-Codina, Anna Esteve-Codina, Albert Quintana, Albert Quintana, Federica Bertaso, Emmanuel Valjent, Laura Cutando, Laura Cutando   +18 more
doaj   +1 more source

Local axonal morphology guides the topography of interneuron myelination in mouse and human neocortex

eLife, 2019
GABAergic fast-spiking parvalbumin-positive (PV) interneurons are frequently myelinated in the cerebral cortex. However, the factors governing the topography of cortical interneuron myelination remain incompletely understood.
Jeffrey Stedehouder, Demi Brizee, Johan A Slotman, Maria Pascual-Garcia, Megan L Leyrer, Bibi LJ Bouwen, Clemens MF Dirven, Zhenyu Gao, David M Berson, Adriaan B Houtsmuller, Steven A Kushner   +10 more
doaj   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

Neuroinflammation and Prefrontal Cortical Microcircuits: A Narrative Review of Hints from Experimental Models

Cells
Neuroinflammation is increasingly recognized as a major contributor to cognitive and neuropsychiatric dysfunction. The prefrontal cortex (PFC), a key substrate for executive functions and emotional behaviors, appears particularly vulnerable to ...
Maria Concetta Geloso, Gabriele Di Sante, Alberto Granato   +2 more
doaj   +1 more source