Results 61 to 70 of about 118,802 (309)
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Two types of somatostatin-expressing GABAergic interneurons in the superficial layers of the mouse cingulate cortex. [PDF]
PLoS ONE, 2018 Somatostatin-expressing (SOM+), inhibitory interneurons represent a heterogeneous group of cells and given their remarkable diversity, classification of SOM+ interneurons remains a challenging task.
Therese Riedemann +2 more
doaj +1 more source
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
Nature Reviews Neuroscience, 2008 Neuroscience produces a vast amount of data from an enormous diversity of neurons. A neuronal classification system is essential to organize such data and the knowledge that is derived from them.
G. Ascoli +38 more
semanticscholar +1 more source
Journal of Neuroscience, 2020 Distinct components of working memory are coordinated by different classes of inhibitory interneurons in the PFC, but the role of cholecystokinin (CCK)-positive interneurons remains enigmatic.
Robin Nguyen +9 more
semanticscholar +1 more source
Interneurons: Learning on the Job [PDF]
Neuron, 2019 In this issue, Wester et al. (2019) examine the obligate relationship between cortical interneurons and pyramidal neurons. By genetically converting superficial IT pyramidal cells into PT-like deep-layer pyramidal cells, they alter the position, connectivity, and gene expression within CGE-derived interneurons.
Renata, Batista-Brito, Gord, Fishell
openaire +2 more sources
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders
Frontiers in Molecular Neuroscience, 2018 Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that PV cells and PNN are impaired in a variety of neurological disorders.
Teresa H. Wen +6 more
doaj +1 more source
Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq
Cell Reports, 2018 Summary Striatal locally projecting neurons, or interneurons, act on nearby circuits and shape functional output to the rest of the basal ganglia. We performed single-cell RNA sequencing of striatal cells enriching for interneurons.
A. Muñoz-Manchado +10 more
semanticscholar +1 more source
Advanced Science, EarlyView.An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong +14 more
wiley +1 more source
Fear Learning Regulates Cortical Sensory Representations by Suppressing Habituation
Frontiers in Neural Circuits, 2018 Projections from auditory cortex to the amygdala are thought to contribute to the induction of auditory fear learning. In addition, fear conditioning has been found to enhance cortical responses to conditioned tones, suggesting that cortical plasticity ...
Shea N. Gillet +5 more
doaj +1 more source