Results 21 to 30 of about 118,802 (309)
Interneuron development and dysfunction [PDF]
The FEBS Journal, 2021 Understanding excitation and inhibition balance in the brain begins with the tale of two basic types of neurons, glutamatergic projection neurons and GABAergic interneurons. The diversity of cortical interneurons is contributed by multiple origins in the ventral forebrain, various tangential migration routes, and complicated regulations of intrinsic ...
Jiaxin Yang, Xiong Yang, Ke Tang
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Building thalamic neuronal networks during mouse development
Frontiers in Neural Circuits, 2023 The thalamic nuclear complex contains excitatory projection neurons and inhibitory local neurons, the two cell types driving the main circuits in sensory nuclei.
Irene Huerga-Gómez +2 more
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Progression of Fetal Brain Lesions in Tuberous Sclerosis Complex
Frontiers in Neuroscience, 2020 Tuberous sclerosis (TSC) is a multisystem autosomal dominant genetic disorder due to loss of function of TSC1/TSC2 resulting in increased mTOR (mammalian target of rapamycin) signaling.
Antoinette Bernabe Gelot +2 more
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eLife, 2023 The way neurons in the brain rewire in larvae as they turn to adult fruit flies sheds light on how complete metamorphosis was ‘invented’ over the course of evolution.
Andreas S Thum, Bertram Gerber
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KCNQ2 channels regulate the population activity of neonatal GABAergic neurons ex vivo
Frontiers in Neurology, 2023 Over the last decade KCNQ2 channels have arisen as fundamental and indispensable regulators of neonatal brain excitability, with KCNQ2 loss-of-function pathogenic variants being increasingly identified in patients with developmental and epileptic ...
Bowen Hou +3 more
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Frontiers in Neural Circuits, 2021 Circuit interactions within the medial entorhinal cortex (MEC) translate movement into a coherent code for spatial location. Entorhinal principal cells are subject to strong lateral inhibition, suggesting that a disinhibitory mechanism may drive their ...
Saishree Badrinarayanan +6 more
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GABAergic interneurons in the neocortex: From cellular properties to circuits
Neuron, 2016 Cortical networks are composed of glutamatergic excitatory projection neurons and local GABAergic inhibitory interneurons which gate signal flow and sculpt network dynamics. Although they represent a minority of the total neocortical neuronal population,
R. Tremblay, Soohyun Lee, B. Rudy
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Journal of Neuroscience, 2020 γ-frequency oscillations (30-120 Hz) in cortical networks influence neuronal encoding and information transfer, and are disrupted in multiple brain disorders.
P. Antonoudiou +4 more
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Modeling interneuron-specific (IS) interneurons in hippocampus [PDF]
BMC Neuroscience, 2014 The hippocampus and cortex have a large diversity in inhibitory interneuron types. These local interneurons exert inhibitory control over neuronal populations in the hippocampus [1]. Although much is known about how hippocampal inhibitory interneurons exert control over pyramidal cells and synchronize local network activity, less is known about how the
Guet-McCreight, Alexandre +3 more
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Stem Cell Reports, 2017 Converting resident glia into functional and subtype-specific neurons in vivo by delivering reprogramming genes directly to the brain provides a step forward toward the possibility of treating brain injuries or diseases.
Maria Pereira +6 more
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