Results 21 to 30 of about 82,209 (267)

Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice

Frontiers in Cell and Developmental Biology, 2020
Neural stem cells in the lateral ganglionic eminence (LGE) generate progenitors that migrate through the rostral migratory stream (RMS) to repopulate olfactory bulb (OB) interneurons, but the regulation of this process is poorly defined.
Christopher A. Blackwood, Christopher A. Blackwood, Christopher A. Blackwood, Alessandro Bailetti, Sayan Nandi, Thomas Gridley, Jean M. Hébert   +6 more
doaj   +1 more source

Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons

Frontiers in Psychiatry, 2023
The muscarinic acetylcholine receptor (mAChR) antagonist, scopolamine, has been shown to have a rapid antidepressant effect. And it is believed that GABAergic interneurons play a crucial role in this action.
Huanxin Chen, Huanxin Chen, Ting He, Meiyi Li, Chunlian Wang, Chen Guo, Wei Wang, Wei Wang, Baocong Yu, Jintao Huang, Lijun Cui, Ping Guo, Yonggui Yuan, Tao Tan, Tao Tan   +14 more
doaj   +1 more source

The Interneuron Class Struggle [PDF]

Cell, 2020
In this issue of Cell, Gouwens et al. establish the state of the art for defining inhibitory cell types in the mouse neocortex. By combining morphological, electrophysiological, and transcriptomic features to classify interneurons in the mouse visual cortex, this work provides a roadmap for understanding the diversity of cell types and their functional
Jacob M, Ratliff, Renata, Batista-Brito
openaire   +2 more sources

Sex differences in the distribution and density of regulatory interneurons in the striatum

Frontiers in Cellular Neuroscience
IntroductionDysfunction of the cortico-basal circuitry – including its primary input nucleus, the striatum – contributes to neuropsychiatric disorders, such as autism and Tourette Syndrome (TS).
Meghan Van Zandt, Deirdre Flanagan, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger   +6 more
doaj   +1 more source

Synaptic plasticity facilitates oscillations in a V1 cortical column model with multiple interneuron types

Frontiers in Computational Neuroscience
Neural rhythms are ubiquitous in cortical recordings, but it is unclear whether they emerge due to the basic structure of cortical microcircuits or depend on function.
Giulia Moreni, Licheng Zou, Cyriel M. A. Pennartz, Cyriel M. A. Pennartz, Jorge F. Mejias, Jorge F. Mejias   +5 more
doaj   +1 more source

Selected issues of GABA metabolism and its potential role in neuropsychiatric disorders.

Journal of Medical Science, 2017
This mini review is limited to chosen problems about GABA metabolism mainly in aspect of associated disorders. GABA primarily identified as inhibitory neurotransmitter plays also excitatory function.
Andrzej Kostyrko
doaj   +1 more source

GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex

Frontiers in Cellular Neuroscience, 2023
Extrasynaptic GABAA receptors (GABAARs) mediating tonic inhibition are thought to play an important role in the regulation of neuronal excitability. However, little is known about a cell type-specific tonic inhibition in molecularly distinctive types of ...
Karolina Bogaj, Roksana Kaplon, Joanna Urban-Ciecko   +2 more
doaj   +1 more source

Olfactory deficits in aging and Alzheimer’s—spotlight on inhibitory interneurons

Frontiers in Neuroscience
Cognitive function in healthy aging and neurodegenerative diseases like Alzheimer’s disease (AD) correlates to olfactory performance. Aging and disease progression both show marked olfactory deficits in humans and rodents.
Kaoutar Elhabbari, Siran Sireci, Markus Rothermel, Daniela Brunert   +3 more
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies

eLife, 2019
Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing.
Jonathan H Cornford, Marion S Mercier, Marco Leite, Vincent Magloire, Michael Häusser, Dimitri M Kullmann   +5 more
doaj   +1 more source