Results 21 to 30 of about 83,755 (215)

Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons

Frontiers in Psychiatry, 2023
The muscarinic acetylcholine receptor (mAChR) antagonist, scopolamine, has been shown to have a rapid antidepressant effect. And it is believed that GABAergic interneurons play a crucial role in this action.
Huanxin Chen, Huanxin Chen, Ting He, Meiyi Li, Chunlian Wang, Chen Guo, Wei Wang, Wei Wang, Baocong Yu, Jintao Huang, Lijun Cui, Ping Guo, Yonggui Yuan, Tao Tan, Tao Tan   +14 more
doaj   +1 more source

Sex differences in the distribution and density of regulatory interneurons in the striatum

Frontiers in Cellular Neuroscience
IntroductionDysfunction of the cortico-basal circuitry – including its primary input nucleus, the striatum – contributes to neuropsychiatric disorders, such as autism and Tourette Syndrome (TS).
Meghan Van Zandt, Deirdre Flanagan, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger   +6 more
doaj   +1 more source

Synaptic plasticity facilitates oscillations in a V1 cortical column model with multiple interneuron types

Frontiers in Computational Neuroscience
Neural rhythms are ubiquitous in cortical recordings, but it is unclear whether they emerge due to the basic structure of cortical microcircuits or depend on function.
Giulia Moreni, Licheng Zou, Cyriel M. A. Pennartz, Cyriel M. A. Pennartz, Jorge F. Mejias, Jorge F. Mejias   +5 more
doaj   +1 more source

Selected issues of GABA metabolism and its potential role in neuropsychiatric disorders.

Journal of Medical Science, 2017
This mini review is limited to chosen problems about GABA metabolism mainly in aspect of associated disorders. GABA primarily identified as inhibitory neurotransmitter plays also excitatory function.
Andrzej Kostyrko
doaj   +1 more source

Olfactory deficits in aging and Alzheimer’s—spotlight on inhibitory interneurons

Frontiers in Neuroscience
Cognitive function in healthy aging and neurodegenerative diseases like Alzheimer’s disease (AD) correlates to olfactory performance. Aging and disease progression both show marked olfactory deficits in humans and rodents.
Kaoutar Elhabbari, Siran Sireci, Markus Rothermel, Daniela Brunert   +3 more
doaj   +1 more source

Complementing Engel Classification: Postoperative Scalp EEG as an Objective Indicator in SEEG‐Guided Radiofrequency Thermocoagulation—A Seizure‐Onset Pattern‐Based Stratified Analysis—

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) is a minimally invasive therapy for drug‐resistant focal epilepsy. However, the relationship between specific seizure‐onset patterns (SOPs), particularly low‐voltage fast activity (LVFA), and postoperative scalp EEG normalization remains inadequately ...
Yi‐qing Yang, Rui Zhang, Haiyan Ma, Lu Yang, Xuefeng Qu, Qiqi Chen, Yan Zhang   +6 more
wiley   +1 more source

Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies

eLife, 2019
Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing.
Jonathan H Cornford, Marion S Mercier, Marco Leite, Vincent Magloire, Michael Häusser, Dimitri M Kullmann   +5 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma [PDF]

Advanced science
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Hong E, Lin C, Long W, Kim I, Xiong M, Wu Z, Rao S, Wang Q.   +7 more
europepmc   +2 more sources