Results 11 to 20 of about 82,209 (267)
Cortical interneurons in autism
Nature Neuroscience, 2021 The mechanistic underpinnings of autism remain a subject of debate and controversy. Why do individuals with autism share an overlapping set of atypical behaviors and symptoms, despite having different genetic and environmental risk factors? A major challenge in developing new therapies for autism has been the inability to identify convergent neural ...
Anis Contractor +2 more
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Frontiers in Neural Circuits, 2021 Circuit interactions within the medial entorhinal cortex (MEC) translate movement into a coherent code for spatial location. Entorhinal principal cells are subject to strong lateral inhibition, suggesting that a disinhibitory mechanism may drive their ...
Saishree Badrinarayanan +6 more
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Modeling interneuron-specific (IS) interneurons in hippocampus [PDF]
BMC Neuroscience, 2014 The hippocampus and cortex have a large diversity in inhibitory interneuron types. These local interneurons exert inhibitory control over neuronal populations in the hippocampus [1]. Although much is known about how hippocampal inhibitory interneurons exert control over pyramidal cells and synchronize local network activity, less is known about how the
Guet-McCreight, Alexandre +3 more
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Stem Cell Reports, 2017 Converting resident glia into functional and subtype-specific neurons in vivo by delivering reprogramming genes directly to the brain provides a step forward toward the possibility of treating brain injuries or diseases.
Maria Pereira +6 more
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Interneurons Scratch an Itch [PDF]
Neuron, 2014 Itch is immensely frustrating. Most studies focus on the cause of itch. In this issue of Neuron, Kardon et al. (2014) find that itch can be modulated by inhibitory neurons that produce dynorphin, an endogenous agonist of κ-opioid receptors.
Pereira, Paula Juliana Seadi +1 more
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Layer 5 Callosal Parvalbumin-Expressing Neurons: A Distinct Functional Group of GABAergic Neurons
Frontiers in Cellular Neuroscience, 2018 Previous studies have shown that parvalbumin-expressing neurons (CC-Parv neurons) connect the two hemispheres of motor and sensory areas via the corpus callosum, and are a functional part of the cortical circuit.
Hector Zurita +2 more
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Frontiers in Neural Circuits, 2021 Prefrontal cortical GABAergic interneurons (INs) and their innervations are essential for the execution of complex behaviors such as working memory, social behavior, and fear expression.
Sha-Sha Yang +4 more
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Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia
Frontiers in Behavioral Neuroscience, 2019 Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cognitive
Alexei M. Bygrave +6 more
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Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions
Frontiers in Physiology, 2018 Systematic research on the physiological and anatomical characteristics of spinal cord interneurons along with their functional output has evolved for more than one century.
Marie-Pascale Côté +4 more
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Structural Changes Observed in the Piriform Cortex in a Rat Model of Pre-motor Parkinson’s Disease
Frontiers in Cellular Neuroscience, 2018 Early diagnosis of Parkinson’s disease (PD) offers perhaps, the most promising route to a successful clinical intervention, and the use of an animal model exhibiting symptoms comparable to those observed in PD patients in the early stage of the disease ...
Marco Sancandi +4 more
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