Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum [PDF]
Nature Communications, 2018 Despite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucleus ...
Shannon L. Wolfman +7 more
doaj +6 more sources
Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion [PDF]
Nature Communications, 2022 Appropriate processing of value information is essential for survival. Here the authors show that in mice, serotonergic activations originating from the median raphe nucleus facilitated aversion in a pathway-dependent manner, while silencing this pathway
Hiroyuki Kawai +17 more
doaj +4 more sources
Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus [PDF]
eLife, 2023 Nicotine intake is likely to result from a balance between the rewarding and aversive properties of the drug, yet the individual differences in neural activity that control aversion to nicotine and their adaptation during the addiction process remain ...
Sarah Mondoloni +12 more
doaj +3 more sources
A Cooperative Mechanism Involving Ca2+-Permeable AMPA Receptors and Retrograde Activation of GABAB Receptors in Interpeduncular Nucleus Plasticity [PDF]
Cell Reports, 2017 Summary: The medial habenula-interpeduncular nucleus (MHb-IPN) pathway, which connects the limbic forebrain to the midbrain, has recently been implicated in aversive behaviors.
Peter Koppensteiner +2 more
doaj +4 more sources
Medial Habenula-Interpeduncular Nucleus Circuit Contributes to Anhedonia-Like Behavior in a Rat Model of Depression [PDF]
Frontiers in Behavioral Neuroscience, 2018 The habenula is a nuclear complex composed of the lateral habenula (LHb) and medial habenula (MHb), two distinct structures. Much progress has been made to emphasize the role of the LHb in the pathogenesis of depression.
Chunpeng Xu +6 more
doaj +4 more sources
Netrin-1/DCC Signaling Differentially Regulates the Migration of Pax7, Nkx6.1, Irx2, Otp, and Otx2 Cell Populations in the Developing Interpeduncular Nucleus [PDF]
Frontiers in Cell and Developmental Biology, 2020 The interpeduncular nucleus (IPN) is a hindbrain structure formed by three main subdivisions, the prodromal (Pro) domain located at the isthmus (Ist), and the rostral and caudal interpeduncular domains (IPR, IPC) within rhombomere 1 (r1).
Isabel M. García-Guillén +14 more
doaj +4 more sources
Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice [PDF]
Scientific ReportsNicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb)–interpeduncular nucleus (IPN) pathway play critical roles in nicotine-related behaviors.
Asuka Tsuzuki +7 more
doaj +4 more sources
Genetic dissection of medial habenula–interpeduncular nucleus pathway function in mice [PDF]
Frontiers in Behavioral Neuroscience, 2013 The habenular complex linking forebrain and midbrain structures is subdivided into the medial (mHb) and the lateral nuclei (lHb). The mHb is characterized by the expression of specific nicotinic acetylcholine receptor isoforms and the release of ...
Yuki eKobayashi +12 more
doaj +4 more sources
Shentong Zhuyu Decoction Alleviates Neuropathic Pain in Mice by Inhibiting the NMDAR-2B Receptor-Mediated CaMKII/CREB Signaling Pathway in GABAergic Neurons of the Interpeduncular Nucleus [PDF]
PharmaceuticalsBackground: Shentong Zhuyu Decoction (STZYD) is a traditional Chinese medicine formula that has shown promise in alleviating neuropathic pain (NPP), yet its central mechanisms remain unclear.
Ying Liu +5 more
doaj +4 more sources
Multiple Regionalized Genes and Their Putative Networks in the Interpeduncular Nucleus Suggest Complex Mechanisms of Neuron Development and Axon Guidance [PDF]
Frontiers in Neuroanatomy, 2021 The interpeduncular nucleus (IPN) is a highly conserved limbic structure in the vertebrate brain, located in the isthmus and rhombomere 1. It is formed by various populations that migrate from different sites to the distinct domains within the IPN: the ...
Isabel M. García-Guillén +4 more
doaj +2 more sources