Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion. [PDF]
Eur J NeurosciABSTRACT The medial habenula–interpeduncular nucleus pathway is a highly conserved and densely innervated brain circuit known for its unique cholinergic transmission and exceptional expression of nicotinic acetylcholine receptors. This pathway plays a critical role in regulating motivational and emotional processes, particularly those related to ...
Ciscato M, Chouvaeff M, Mourot A.
europepmc +5 more sources
Clarifying the Role of the Rostral Interpeduncular Nucleus in Aversion to Nicotine. [PDF]
J Neurosci, 2019 Genetic and environmental factors contribute to an individual's sensitivity to drug reward and aversion, thereby influencing their susceptibility to drug abuse and addiction. A genetic variant (D398N) in the gene CHRNA5 , which encodes the α5 subunit of the nicotinic acetylcholine receptor ...
Brynildsen JK.
europepmc +5 more sources
Visual motion and landmark position align with heading direction in the zebrafish interpeduncular nucleus [PDF]
Nature CommunicationsSensory information is fundamental for navigation. Visual motion is used by animals to estimate their traveling distance and direction, and landmarks allow animals to tether their location and orientation to their environment.
Hagar Lavian +4 more
doaj +2 more sources
Organization of multisynaptic inputs to the dorsal and ventral dentate gyrus: retrograde trans-synaptic tracing with rabies virus vector in the rat. [PDF]
PLoS ONE, 2013 Behavioral, anatomical, and gene expression studies have shown functional dissociations between the dorsal and ventral hippocampus with regard to their involvement in spatial cognition, emotion, and stress. In this study we examined the difference of the
Shinya Ohara +4 more
doaj +5 more sources
GABAB receptor-mediated potentiation of ventral medial habenula glutamatergic transmission in GABAergic and glutamatergic interpeduncular nucleus neurons [PDF]
IBRO Neuroscience ReportsThe medial habenula (MHb)-interpeduncular nucleus (IPN) pathway plays a crucial role in information transferring between the forebrain and the midbrain, and has been implicated in the regulation of fear behavior and nicotine addiction.
Hannah E. Stinson, Ipe Ninan
doaj +2 more sources
Increased metabolic activity in the septum and habenula during stress is linked to subsequent expression of learned helplessness behavior [PDF]
Frontiers in Human Neuroscience, 2014 Uncontrollable stress can have a profound effect on an organism’s ability to respond effectively to future stressful situations. Behavior subsequent to uncontrollable stress can vary greatly between individuals, falling on a spectrum between healthy ...
Martine M Mirrione +10 more
doaj +2 more sources
Dynamic activity of interpeduncular nucleus GABAergic neurons controls expression of nicotine withdrawal in male mice. [PDF]
Neuropsychopharmacology, 2022 Klenowski PM +4 more
europepmc +3 more sources
Functional α7 nicotinic acetylcholine receptors in GABAergic neurons of the interpeduncular nucleus. [PDF]
Neuropharmacology, 2022 Jin XT, Drenan RM.
europepmc +3 more sources
Brain asymmetry is encoded at the level of axon terminal morphology [PDF]
Neural Development, 2008 Background Functional lateralization is a conserved feature of the central nervous system (CNS). However, underlying left-right asymmetries within neural circuitry and the mechanisms by which they develop are poorly described.
Russell Claire +4 more
doaj +4 more sources
Specific Inhibition of Interpeduncular Nucleus GABAergic Neurons Alleviates Anxiety-Like Behaviors in Male Mice after Prolonged Abstinence from Methamphetamine. [PDF]
J Neurosci, 2023 Xu X +10 more
europepmc +3 more sources