Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. [PDF]
Nat Commun, 2015 Zhao-Shea R +11 more
europepmc +3 more sources
Integrated miRNA-/mRNA-Seq of the Habenulo-Interpeduncular Circuit During Acute Nicotine Withdrawal
Scientific Reports, 2020 Tobacco use is the leading preventable cause of mortality in the world. The limited number of smoking cessation aids currently available are minimally effective, highlighting the need for novel therapeutic interventions.
Alison P. Casserly +7 more
doaj +1 more source
GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals
eLife, 2021 The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors and uniquely expresses R-type Ca2+ channels (Cav2.3) and auxiliary GABAB receptor (GBR) subunits, the K+-channel tetramerization
Pradeep Bhandari +12 more
doaj +1 more source
Frontiers in Neuroanatomy, 2022 This study reports for the first time the distribution and morphological characterization of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d; a reliable marker of nitric oxide synthase activity) positive elements in the central nervous ...
Manuel A. Pombal +3 more
doaj +1 more source
The Scalable Brain Atlas: instant web-based access to public brain atlases and related content [PDF]
, 2014 The Scalable Brain Atlas (SBA) is a collection of web services that provide unified access to a large collection of brain atlas templates for different species.
Bakker, Rembrandt +2 more
core +5 more sources
Fetal Medial Habenula Transplants: Innervation of the Rat Interpeduncular Nucleus [PDF]
Neural Plasticity, 1989 The effects of donor age and site of placement on the survival of fetal medial habenula (MH) transplants into adult rats hosts were examined. The innervation of the interpeduncular nucleus (IPN) in such cases was also examined. Explants of MH consisting of the medial‐dorsal lip of the third ventricle were held in vitro for 1—2 days.
Lenn, Nicholas J. +3 more
openaire +2 more sources
Mapping of neurokinin-like immunoreactivity in the human brainstem
BMC Neuroscience, 2003 Background Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.
Narvaez Jose +10 more
doaj +1 more source
An Evolutionary Hypothesis of Binary Opposition in Functional Incompatibility about Habenular Asymmetry in Vertebrates [PDF]
, 2017 Many vertebrates have asymmetrical circuits in the nervous system. There are two types of circuit asymmetry. Asymmetrical circuits in sensory and/or motor systems are usually related to lateralized behaviors.
Agetsuma +63 more
core +2 more sources
Griseum centrale, a homologue of the periaqueductal gray in the lamprey
IBRO Reports, 2017 Fear, a response to threatening stimuli and important for survival, is a behavior found throughout the animal kingdom. One critical structure involved in the expression of fear-related behavior is the periaqueductal gray (PAG) in mammals, and in the ...
Ian Olson +3 more
doaj +1 more source
Understanding the habenula: A major node in circuits regulating emotion and motivation
Pharmacological Research, 2023 Over the last decade, the understanding of the habenula has rapidly advanced from being an understudied brain area with the Latin name ‘habena” meaning “little rein”, to being considered a “major rein” in the control of key monoaminergic brain centers ...
Jessica L. Ables +2 more
doaj +1 more source