Results 1 to 10 of about 30,644 (144)

Intranasal delivery systems for traumatic brain injury: Advancements and perspectives [PDF]

Journal of Tissue Engineering
Traumatic brain injury (TBI) is a major cause of mortality and morbidity, commonly leading to long-term impairments in cognition, sensorimotor function, and personality. While neuroprotective drugs have demonstrated some efficacy in vitro cultures and in
Shin Hyuk Yoo, Soon Chul Heo, Jun Sang Bae, Jun Hee Lee, Jonathan C. Knowles, Hae-Won Kim   +5 more
doaj   +2 more sources

Intranasal Delivery of Ketamine Induces Cortical Disinhibition. [PDF]

eNeuro, 2023
Our previous studies find that subcutaneously administered (s.c.) subanesthetic ketamine promotes sustained cortical disinhibition and plasticity in adult mouse binocular visual cortex (bV1). We hypothesized that intranasal delivery (i.n.) of subanesthetic ketamine may have similar actions.
Qiao X, Grieco SF, Yu Z, Holmes TC, Xu X.   +4 more
europepmc   +5 more sources

Intranasal delivery of rotigotine to the brain for treating Parkinson’s disease [PDF]

Fundamental Research
: The development of sustainable and non-invasive method for delivering drugs to the brain is crucial for the effective treatment of Parkinson’s disease (PD).
Dandan Kou, Keyang Xu, Jiahui Yin, Ning Wang, Ruru Zhang, Jianfeng Zeng, Mingyuan Gao   +6 more
doaj   +2 more sources

Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants [PDF]

Signal Transduction and Targeted Therapy
The mucosal immune response plays a crucial role in the prevention of respiratory viruses. Given the risk of recurrent SARS-CoV-2 infections in the population, the rapid development of next-generation intranasal COVID-19 vaccines with high safety and ...
Hong Lei, Weiqi Hong, Jingyun Yang, Cai He, Yanan Zhou, Yu Zhang, Aqu Alu, Jie Shi, Jian Liu, Furong qin, Danyi Ao, Xiya Huang, Zimin Chen, Hao Yang, Yun Yang, Wenhai Yu, Cong Tang, Junbin Wang, Bai Li, Qing Huang, Hongbo Hu, Wei Cheng, Haohao Dong, Jian Lei, Lu Chen, Xikun Zhou, Jiong Li, Li Yang, Zhenling Wang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Guangwen Lu, Qiangming Sun, Youchun Wang, Shuaiyao Lu, Xiawei Wei   +38 more
doaj   +2 more sources

Rapid and Widespread Distribution of Intranasal Small Extracellular Vesicles Derived from Mesenchymal Stem Cells throughout the Brain Potentially via the Perivascular Pathway

Pharmaceutics, 2023
Intranasal administration is a promising strategy to enhance the delivery of the sEVsomes-based drug delivery system to the central nervous system (CNS).
Weiwei Shen, Tongyao You, Wenqing Xu, Yanan Xie, Yingzhe Wang, Mei Cui   +5 more
doaj   +1 more source

Differential Biodistribution of Adenoviral-Vectored Vaccine Following Intranasal and Endotracheal Deliveries Leads to Different Immune Outcomes

Frontiers in Immunology, 2022
Infectious diseases of the respiratory tract are one of the top causes of global morbidity and mortality with lower respiratory tract infections being the fourth leading cause of death.
Vidthiya Jeyanathan, Vidthiya Jeyanathan, Sam Afkhami, Sam Afkhami, Michael R. D’Agostino, Michael R. D’Agostino, Anna Zganiacz, Anna Zganiacz, Xueya Feng, Xueya Feng, Matthew S. Miller, Matthew S. Miller, Mangalakumari Jeyanathan, Mangalakumari Jeyanathan, Michael R. Thompson, Zhou Xing, Zhou Xing   +16 more
doaj   +1 more source

Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System

Pharmaceutics, 2022
The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB.
Oxana Semyachkina-Glushkovskaya, Alexander Shirokov, Inna Blokhina, Valeria Telnova, Elena Vodovozova, Anna Alekseeva, Ivan Boldyrev, Ivan Fedosov, Alexander Dubrovsky, Alexandr Khorovodov, Andrey Terskov, Arina Evsukova, Daria Elovenko, Viktoria Adushkina, Maria Tzoy, Ilana Agranovich, Jürgen Kurths, Edik Rafailov   +17 more
doaj   +1 more source

Recent Developments In Brain-Targeted Drug Delivery Systems via Intranasal Route [PDF]

Farmacja Polska, 2023
Diseases of the human nervous system such as neurological infections, Parkinson's, Alzheimer's, and other neurodegenerative diseases are severe pathological diseases and become a public health problem.
Ahmad Ainurofiq, Aji Prasetya, Bingah Ginanjar Rahayu, Muhammad Syayiq Al Qadri, Myrat Kovusov, Ophira Evangelista Putri Laksono   +5 more
doaj   +1 more source

The hidden obstacles to intranasal insulin delivery: A narrative review

Journal of Diabetology, 2023
A large number of people are suffering with one or the other type of diabetes around the globe. Insulin has proven to be beneficial for the treatment of both types of diabetes.
Ujjawal Rawat, Ambika Choudhary, Piyush Mittal, Anurag Verma   +3 more
doaj   +1 more source

Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System

Frontiers in Pharmacology, 2022
Treatment of central nervous system (CNS) disorders is challenging using conventional delivery strategies and routes of administration because of the presence of the blood–brain barrier (BBB). This BBB restricts the permeation of most of the therapeutics
Manisha Pandey, Neha Jain, Jovita Kanoujia, Zahid Hussain, Bapi Gorain   +4 more
doaj   +1 more source