Results 11 to 20 of about 57,277 (349)

The hidden obstacles to intranasal insulin delivery: A narrative review

Journal of Diabetology, 2023
A large number of people are suffering with one or the other type of diabetes around the globe. Insulin has proven to be beneficial for the treatment of both types of diabetes.
Ujjawal Rawat, Ambika Choudhary, Piyush Mittal, Anurag Verma   +3 more
doaj   +1 more source

Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: effect of instillation volume and form of anesthesia. [PDF]

PLoS ONE, 2012
Intranasal instillation is a widely used procedure for pneumonic delivery of drugs, vaccine candidates, or infectious agents into the respiratory tract of research mice.
Mark A Miller, Jennifer M Stabenow, Jyothi Parvathareddy, Andrew J Wodowski, Thomas P Fabrizio, Xiaowen R Bina, Lillian Zalduondo, James E Bina   +7 more
doaj   +1 more source

Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System

Frontiers in Pharmacology, 2022
Treatment of central nervous system (CNS) disorders is challenging using conventional delivery strategies and routes of administration because of the presence of the blood–brain barrier (BBB). This BBB restricts the permeation of most of the therapeutics
Manisha Pandey, Neha Jain, Jovita Kanoujia, Zahid Hussain, Bapi Gorain   +4 more
doaj   +1 more source

Cochleates derived from Vibrio cholerae O1 proteoliposomes : The impact of structure transformation on mucosal immunisation [PDF]

, 2012
Cochleates are phospholipid-calcium precipitates derived from the interaction of anionic lipid vesicles with divalent cations. Proteoliposomes from bacteria may also be used as a source of negatively charged components, to induce calcium-cochleate ...
Adriana Callicó, Alexander B. Mullen, Bárbara Cedré, Caridad Zayas, David Mckee, Gunnar F. Kaufmann, José L. Pérez, Luis García, Oliver Pérez, Reinaldo Acevedo, Valerie A. Ferro   +10 more
core   +11 more sources

Recent Advances in Intranasal Liposomes for Drug, Gene, and Vaccine Delivery

Pharmaceutics, 2023
Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles produced from cholesterol and phospholipids. Recently, liposomes have been widely administered intranasally for systemic and brain delivery. From the nasal cavity, liposome-
Van-An Duong, Thi-Thao-Linh Nguyen, Han-Joo Maeng   +2 more
doaj   +1 more source

Systemic and brain delivery of antidiabetic peptides through nasal administration using cell-penetrating peptides

Frontiers in Pharmacology, 2022
The intranasal route has emerged as a promising strategy that can direct delivery of drugs into the systemic circulation because the high-vascularized nasal cavity, among other advantages, avoids the hepatic first-pass metabolism.
Jeehye Maeng, Kyunglim Lee
doaj   +1 more source

Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery [PDF]

Frontiers in Chemistry, 2020
في السنوات الأخيرة، أثبتت المواد الهجينة النانوية المتقدمة التي تمت معالجتها كمستحضرات صيدلانية أنها مفيدة للغاية. التريبتان، مثل السوماتريبتان داخل الأنف المتاح تجاريًا (SMT)، هي أدوية تستخدم في علاج أعراض الصداع النصفي المؤلمة. ومع ذلك، فإن فعالية SMT محدودة بسبب أليفتها العالية للماء وضعف التصاق الغشاء المخاطي.
Lígia Nunes de Morais Ribeiro, Gustavo Henrique Rodrigues da Silva, Verônica Muniz Couto, Simone R. Castro, Márcia Cristina Breitkreitz, Carolina Martínez, Daniela E. Igartúa, María Jimena Prieto, Eneida de Paula   +8 more
openaire   +4 more sources

Optimizing Absorption for Intranasal Delivery of Drugs Targeting the Central Nervous System Using Alkylsaccharide Permeation Enhancers

Pharmaceutics, 2023
Intranasal delivery of drugs offers several potential benefits related to ease of delivery, rapid onset, and patient experience, which may be of particular relevance to patients with central nervous system (CNS) conditions who experience acute events ...
Stuart Madden, Enrique Carrazana, Adrian L. Rabinowicz   +2 more
doaj   +1 more source

Design and Application in Delivery System of Intranasal Antidepressants

Frontiers in Bioengineering and Biotechnology, 2020
One of the major reasons why depressed patients fail their treatment course is the existence of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central nervous system (CNS).
Jingying Xu, Jingying Xu, Jiangang Tao, Jiangang Tao, Jidong Wang   +4 more
doaj   +1 more source

A study on toxicity, local irritative effect of and allergic response to a novel intranasal medication containing N-phenylacetyl-L-prolylglycine ethyl ester

Zaporožskij Medicinskij Žurnal, 2021
Development of novel medications for delivery of active ingredients with systemic absorption and high bioavailability is an actual challenge for modern pharmaceutical and medical science.
B. S. Burlaka, I. F. Bielenichev
doaj   +1 more source