Frontiers in MedicineBackgroundThe growing prevalence of autism spectrum disorder (ASD) underscores the urgent need for therapies that target underlying biological mechanisms, with cell-based interventions offering a potentially transformative approach by targeting core ...
Georg S. Kobinia +11 more
doaj +1 more source
Intrathecal B-cell activation in LGI1 antibody encephalitis. [PDF]
, 2020 ObjectiveTo study intrathecal B-cell activity in leucine-rich, glioma-inactivated 1 (LGI1) antibody encephalitis. In patients with LGI1 antibodies, the lack of CSF lymphocytosis or oligoclonal bands and serum-predominant LGI1 antibodies suggests a ...
Dandekar, Ravi +13 more
core
Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]
, 2017 The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria +5 more
core +1 more source
Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]
, 2015 Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine +2 more
core +2 more sources
Symptomatic intrathecal hypertension [PDF]
Neurology Clinical Practice, 2015 The Monro-Kellie doctrine states that since the cranium is an incompressible space, the sum of its contents must remain constant. An increase in one component must be accompanied by a decrease in another component, and even a small increase in the intracranial contents can result in a marked increase in intracranial pressure, causing pain and ...
Awss, Zidan, Deborah Young, Bradshaw
openaire +2 more sources
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients [PDF]
, 2016 Purpose: Methotrexate administration is associated with frequent adverse neurological events during treatment for childhood acute lymphoblastic leukemia.
Baird, Susan F. +5 more
core +2 more sources
Antinociceptive drug interaction between intrathecal vitamin E and gabapentin in the rat formalin test [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundGabapentin is thought to exert an effect through the voltage-dependent calcium channel. Vitamin E is a widely known antioxidant which neutralizes the harmful effect of ROS which is considered to play a prominent role in various painful ...
Myoung-Joong Kim +3 more
doaj +1 more source
Transversus abdominis plane blocks; a national survey of techniques used by UK obstetric anaesthetists [PDF]
, 2011 No abstract ...
Kearns, R.J., Young, S.J.
core +1 more source
Indian Journal of Anaesthesia, 2015 Background and Aim: The newer trend in regional anaesthesia for ambulatory anorectal surgeries advocate use of lower dose of local anaesthetic, providing segmental block with adjuvants such as opioids and α2 agonists to prolong analgesia.
S S Nethra +5 more
doaj +1 more source
Effects of intrathecal opioids use in cesarean section on breastfeeding and newborns’ weight gaining [PDF]
, 2016 Objective: To assess the association between intrapartum intrathecal opioid use and breastfeeding and weight gain following cesarean section. Materials and methods: The prospective double-blinded study was conducted on term pregnant women, undergoing ...
Anbarafshan, Mohammad +6 more
core +1 more source