Results 101 to 110 of about 141,619 (287)

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Embodied cognitive ecosophy: the relationship of mind, body, meaning and ecology [PDF]

, 2017
The concept of embodied cognition has had a major impact in a number of disciplines. The extent of its consequences on general knowledge and epistemology are still being explored.
Aizawa Ken., Bateson Gregory., Charmaz K., Chawda Bejal, Damasio Antonio., Dawson Michael., Deleuze G., Dennett Daniel C., Derek Jones, Descartes Rene., Dunning David., Foucault Michel., Gallagher Shaun., Gibson James J., Guattari Felix., Heidegger Martin., Keller David R., Khun Thomas S., Koskinen Ilpo, Lakoff George, Lakoff George, Latour Bruno., Longhurst Robyn, Malafouris Lambros., Mallgrave Harry Francis., Merleau-Ponty Maurice., Michaels Claire F., Norman Donald A., Pirsig Robert., Russell Bertrand., Shapiro Lawrence A., Wilson Frank R.   +31 more
core   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Differential effects of a fixed and a faded motivational scaffold on cognitive load and learning in multimedia environments

Knowledge Management & E-Learning: An International Journal
The research compares the effects of two motivational scaffolding models included in a multimedia environment that addresses technological content and evaluates their influence on cognitive load and academic performance in students with different ...
Sonia Triana-Vera, Omar López-Vargas
doaj   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Using virtual reality for enhancing neuroanatomy learning by optimizing cognitive load and intrinsic motivation

Computers & Education
This research investigates the effectiveness of virtual reality (VR) in enhancing neuroanatomy learning among medical students, focusing on optimizing cognitive load, intrinsic motivation, and user experience. A total of 77 s-year medical students participated in the study, which compared traditional video-based instruction with three VR conditions ...
M. Poupard, F. Larrue, M. Bertrand, D. Liguoro, A. Tricot, H. Sauzéon   +5 more
openaire   +2 more sources

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

The Effectiveness of Learning Two Stay Two Stray to Reduce Cognitive Load Accordance Student Learning Styles [PDF]

, 2015
This research is motivated by the lack of effectiveness in the learning process in receiving and processing information to acquire reasoning abilities as students still had cognitive load. The purpose of this study was to determine the effect of learning
Munandar, R. R. (Rifki), Topik Hidayat, Adi Rahmat   +1 more
core  

Factors Influencing Individual Performance in an Indonesian Government Office [PDF]

, 2013
Reformation in Indonesian government offices leads to many substantial changes, and demands improved job performances while arguably loading employees with more work.
Marpaung, S. B. (Sally), Munawaroh, A. (Azizatul), Riantoputra, C. D. (Corina)   +2 more
core   +3 more sources