Results 121 to 130 of about 3,694,141 (275)

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Bot or Not? Differences in Cognitive Load Between Human- and Chatbot-Led Post-Simulation Debriefings

Education Sciences
Understanding how different debriefing formats impact learner’s cognitive load is crucial for designing effective post-simulation reflection activities.
Dominik Evangelou, Miriam Mulders, Kristian Heinrich Träg   +2 more
doaj   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

On modelling cognitive load during reading task [PDF]

, 2016
One of the main challenges that hugely effect readers’ performance is cognitive load.It plays a pivotal role to facilitate readers to learn, memorize, and digest a piece of novel information. However, cognitive load can also have insignificant impacts on
Ghanimi, Hayder M. A., Ahmad, Faudziah, Ab. Aziz, Azizi   +2 more
core   +2 more sources

Less stress, better scores, same learning: The dissociation of performance and learning in AI-supported programming education

Computers and Education: Artificial Intelligence
Introduction: Generative AI is reshaping programming education, yet its effects on conceptual learning, intrinsic motivation, and cognitive load remain unclear. This study tests whether assistance deepens understanding or primarily boosts task completion,
Patrick Bassner, Ben Lenk-Ostendorf, Ramona Beinstingel, Tobias Wasner, Stephan Krusche   +4 more
doaj   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

The instructional modality used for contextual vertical integration of anatomy influences cognitive load and performance during an operative interpretation task in undergraduate gynaecology students: evidence from a multi-centre cluster-randomised controlled trial

Frontiers in Medicine
IntroductionOperative interpretation is central to the educational value of theatre placements, yet students often struggle to apply preclinical anatomy to the operative setting.
Mohammed Ismail-Khan, Mohammed Ismail-Khan, Mohammed Ismail-Khan, Md. Siddique Ahmed Khan, Jabeen Aslam, Ratna Kumari, Ratna Kumari, Arwa Areej, Ramana Devi, Tallapaneni Sreekanth, Fateen Fatima Mazher, Mohammed Musheer, Porfyrios Korompelis   +12 more
doaj   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Cognitive Load and Learned Helplessness: Examining the Psychological Consequences of Instructional Demands

Jurnal Theorems (The Original Research of Mathematics)
This study investigates the relationships between the dimensions of cognitive load—namely, intrinsic, extraneous, and germane—and learned helplessness among students. The study is grounded in the premise that students’ learning difficulties may not arise
Ahmad Iqbal Hartanto, Mohamad Gilar Jatisunda   +1 more
doaj   +1 more source

Reducing Intrinsic Cognitive Load in Complex Learning Such as Flight Training That Involves Both Cognitive and Psychomotor Tasks

, 2014
Flying an aircraft requires processing or considering great number of inputs and an ability to link these data to a massive amount of information in order to interpret them. As a result, flight training imposes a high intrinsic cognitive load. The focus of this research was to investigate the effect of decreasing intrinsic cognitive load for complex ...
openaire   +2 more sources