Results 11 to 20 of about 100,331 (293)

Interplay between Gating and Block of Ligand-Gated Ion Channels

Brain Sciences, 2020
Drugs that inhibit ion channel function by binding in the channel and preventing current flow, known as channel blockers, can be used as powerful tools for analysis of channel properties.
Matthew B. Phillips, Aparna Nigam, Jon W. Johnson   +2 more
doaj   +1 more source

Force From Filaments: The Role of the Cytoskeleton and Extracellular Matrix in the Gating of Mechanosensitive Channels

Frontiers in Cell and Developmental Biology, 2022
The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion channels that transduce mechanical stimuli with high sensitivity and speed. This conversion process is usually called mechanotransduction.
Yu-Chia Chuang, Chih-Cheng Chen, Chih-Cheng Chen, Chih-Cheng Chen   +3 more
doaj   +1 more source

A new polymodal gating model of the proton-activated chloride channel.

PLoS Biology, 2023
The proton-activated chloride (PAC) channel plays critical roles in ischemic neuron death, but its activation mechanisms remain elusive. Here, we investigated the gating of PAC channels using its novel bifunctional modulator C77304.
Piao Zhao, Cheng Tang, Yuqin Yang, Zhen Xiao, Samantha Perez-Miller, Heng Zhang, Guoqing Luo, Hao Liu, Yaqi Li, Qingyi Liao, Fan Yang, Hao Dong, Rajesh Khanna, Zhonghua Liu   +13 more
doaj   +1 more source

Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating [PDF]

, 2016
The flow of ions through membrane channels is precisely regulated by gates. The architecture and function of these elements have been studied extensively, shedding light on the mechanisms underlying gating.
A Tinker, A Tinker, A Tinker, AR Lindsay, AS Thomson, B Tanna, C Miller, CM Armstrong, CM Wilkens, DA Doyle, DJ Posson, DJ Posson, F Van Petegem, G Yellen, JD Faraldo-Gómez, JF Cordero-Morales, JR Blasic, KL Choi, LG Cuello, M LeMasurier, M Schewe, MJ Lenaeus, MJ Lenaeus, PL Piechotta, R Sitsapesan, R Zalk, RA Piskorowski, S Chakrapani, S Mukherjee, S Mukherjee, S Ramachandran, SA Mason, SJ McGarry, W Chen, W Welch, WUniqueInner Li, XY Ma, Y Liu, Z Yan   +38 more
core   +5 more sources

Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity.

PLoS Computational Biology, 2020
Understanding the gating mechanism of ion channel proteins is key to understanding the regulation of cell signaling through these channels. Channel opening and closing are regulated by diverse environmental factors that include temperature, electrical ...
Juhwan Lee, Mooseok Kang, Sangyeol Kim, Iksoo Chang   +3 more
doaj   +1 more source

Cyclic Nucleotide-Gated Ion Channels [PDF]

Physiological Reviews, 2002
Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct binding of cyclic nucleotides, cAMP and cGMP. Although their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion ...
U Benjamin, Kaupp, Reinhard, Seifert
openaire   +2 more sources

Capacitance fluctuations causing channel noise reduction in stochastic Hodgkin-Huxley systems [PDF]

, 2006
Voltage-dependent ion channels determine the electric properties of axonal cell membranes. They not only allow the passage of ions through the cell membrane but also contribute to an additional charging of the cell membrane resulting in the so-called ...
Adrian R H, Bezrukov S M, Chow C C, Clay J R, G Schmid, Gong Y B, Hille B, Hodgkin A, Hodgkin A L, Hänggi P, Hänggi P, Hänggi P, I Goychuk, Keynes R D, Koch K, Lecar H, Nossal R J, P Hänggi, Press W H, Schmid G, Shuai J W, Skaugen E, Strassberg A F   +22 more
core   +3 more sources

Ion channels gated by heat [PDF]

Proceedings of the National Academy of Sciences, 1999
All animals need to sense temperature to avoid hostile environments and to regulate their internal homeostasis. A particularly obvious example is that animals need to avoid damagingly hot stimuli. The mechanisms by which temperature is sensed have until recently been mysterious, but in the last couple of years, we have begun to understand how ...
Cesare P., Moriondo A., Vellani V., Mcnaughton P. A.   +3 more
openaire   +2 more sources

Voltage-dependent gating in a "voltage sensor-less" ion channel. [PDF]

PLoS Biology, 2010
The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity.
Harley T Kurata, Markus Rapedius, Marc J Kleinman, Thomas Baukrowitz, Colin G Nichols   +4 more
doaj   +1 more source

Fractional diffusion modeling of ion channel gating [PDF]

, 2004
An anomalous diffusion model for ion channel gating is put forward. This scheme is able to describe non-exponential, power-law like distributions of residence time intervals in several types of ion channels.
A. L. Hodgkin, A. Toib, B. D. Hughes, B. Hille, D. R. Cox, G. Doetsch, G. H. Weiss, G. H. Weiss, Igor Goychuk, M. A. Lavrentiev, M. F. Shlesinger, N. G. van Kampen, N. W. Goel, Peter Hänggi, R. Gorenflo, R. L. Stratonovich   +15 more
core   +1 more source