Results 91 to 100 of about 4,777,996 (166)
The Effects of Glucagon-like Peptide-2 on the Tight Junction and Barrier Function in IPEC-J2 Cells through Phosphatidylinositol 3-kinase–Protein Kinase B–Mammalian Target of Rapamycin Signaling Pathway [PDF]
Asian-Australasian Journal of Animal Sciences, 2016 Glucagon-like peptide-2 (GLP-2) is important for intestinal barrier function and regulation of tight junction (TJ) proteins, but the intracellular mechanisms of action remain undefined.
Changsong Yu +6 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 3, May 2026.ABSTRACT Magnolol is a natural bioactive phenolic compound with potent antioxidant properties and plays an important role in modulating intestinal healthy. However, the underlying mechanisms of magnolol in alleviating intestinal oxidative stress damage and improving the intestinal barrier integrity remain unknown. Thus, this study aimed to evaluate the
Mengyao Fang +9 more
wiley +1 more source
IPEC-J2 Cells as Reporter System of the Anti-Inflammatory Control Actions of Interferon-Alpha [PDF]
Journal of Interferon & Cytokine Research, 2013 Interferon-alpha (IFN-α) shows potent immunomodulatory properties, which underlies its use for low-dose oral treatments of diverse viral infections and immunopathological conditions. The studies on oral administration have been hampered by the lack of recognized in vitro models, reproducing the in vivo control action of IFN-α over inflammatory cytokine
Elisabetta, Razzuoli +2 more
openaire +2 more sources
Dihydromyricetin Regulates PANoptosis to Protect Salmonella Typhimurium‐Infected Weaned Piglets
Food Frontiers, Volume 7, Issue 2, March 2026.After DHM pretreatment, piglets were subjected to Salmonella infection. Serum and ileocecal samples from the piglets were collected for TUNEL assay, Western blotting analysis, and metabolomics analysis. The results collectively indicated that DHM could protect piglets from Salmonella infection.
Tingting Xiao +6 more
wiley +1 more source
, 2022 The accumulation of reactive oxygen species (ROS) triggers oxidative stress in cells by oxidizing and modifying various cellular components, preventing them from performing their inherent functions, ultimately leading to apoptosis and autophagy ...
Huijie Lu +10 more
core +1 more source
Ecotoxicology and Environmental Safety, 2020 Deoxynivalenol (DON) is extensively detected in many kinds of foods and feeds to harm human and animal health. This research aims to investigate the effect of chlorogenic acid (CGA) on alleviating inflammation and apoptosis of swine jejunal epithelial cells (IPEC-J2) triggered by DON.
Xiaoxiang Xu +8 more
openaire +2 more sources
An Engineered Solidified Peptide Hemocyte Sponge as Nanomotor Storage to Combat Bacterial Colitis
Advanced Science, Volume 13, Issue 8, 9 February 2026.Peptides immobilized via nickel coordination can stabilize the framework structure. Following coating with red blood cell membranes, these constructs are capable of continuously sequestering endotoxins and mitigating colonic pathogenic damage by alleviating bacterial‐induced ferroptosis.
Yuxin Fang +8 more
wiley +1 more source
Effects of Defined Pig Microbiota on Acute Salmonellosis in Gnotobiotic Piglets
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.Germ‐free piglets lack protective microbiota and are highly vulnerable to Salmonella Typhimurium LT2 infection. Pre‐colonization with defined pig microbiota supports early immune response and intestinal barrier maturation. By measuring pathogen spread, intestinal structure, goblet cell density, cytokines, and tight‐junction markers with molecular and ...
Igor Splichal +8 more
wiley +1 more source
, 2013 IPEC-J2 cells of 10,000 cells/well in E-plate96 were observed during 24 h. Data points represent mean values +/− SEM (n = 5 wells).
Christoph Weise (430495) +3 more
core +1 more source
, 2022 Clostridium perfringens beta2 (CPB2) toxin, one of the virulence factors of Clostridium perfringens (C. perfringens), can cause necrotizing enterocolitis in piglets. Accumulating pieces of evidence indicate that microRNAs (miRNAs) refer to the regulation
Pengfei Wang (123133) +9 more
core +1 more source