Results 71 to 80 of about 4,777,996 (166)

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Unraveling the pathogenic potential of the Pentatrichomonas hominis PHGD strain: impact on IPEC-J2 cell growth, adhesion, and gene expression

Parasite
Pentatrichomonas hominis, a flagellated parasitic protozoan, predominantly infects the mammalian digestive tract, often causing symptoms such as abdominal pain and diarrhea. However, studies investigating its pathogenicity are limited, and the mechanisms
Zhu Yibin, Cai Haiming, Fang Siyun, Shen Hanqin, Yan Zhuanqiang, Wang Dingai, Qi Nanshan, Li Juan, Lv Minna, Lin Xuhui, Hu Junjing, Song Yongle, Chen Xiangjie, Yin Lijun, Zhang Jianfei, Liao Shenquan, Sun Mingfei   +16 more
doaj   +1 more source

Serotonin neuromicrobiology: Psychobiotic modulation of the gut–brain axis for mental health

Ibrain, Volume 12, Issue 3, Page 312-329, Fall 2026.
An overview of Psychobiotics and Tryptophan metabolism: A serotonin‐kynurenine crosstalk shaping the Gut‐Brain axis. IDO1, Indoleamine 2,3‐dioxygenase 1; 5‐HT3, 5‐hydroxytryptamine type 3; IFN‐γ, Interferon‐gamma; TNF‐α, Tumor necrosis factor‐alpha; IL‐1β, Interleukin‐1 beta; IL‐6, Interleukin 6; Trp, Tryptophan; 5‐HT, 5‐hydroxy‐tryptamine; 5‐HTP, 5 ...
Nidhi Mandloi, Aarzoo, Chakkaravarthi Saravanan, Heera Ram, Bhim Pratap Singh   +4 more
wiley   +1 more source

Benzothiazepane‐Based Curcumin Analogs Show Selective Effects on Respiration, Permeability, and Growth of Gut‐Liver (Co‐Culture) Cell Models

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Benzothiazephane‐based curcuminoids are more potent than curcumin to inhibit liver cancer outgrowth in a Caco‐2/HepG2 coculture model, depending on methylation and heterocyclic substituent pattern. This may be the result of altered absorption, metabolism, and mitochondrial function, which are relevant targets for drug design.
Fuhua Li, Julie De Munck, Felien Morlion, Katarina Magdalenic, Andreja Rajkovic, Matthias D'hooghe, John Van Camp, Charlotte Grootaert   +7 more
wiley   +1 more source

Fluorescence microscopy imaging of R2LC-mCherry adhering to IPEC-J2 cells.

, 2016
(A) Bright-field image. (B) Fluorescence imaging of the DAPI stained IPEC-J2 cells. (C) Fluorescence imaging of R2LC-mCherry. (D) Merging of the B and C images.
David Ahl (347515), Hans Jonsson (2579209), Lena Holm (243553), Shokoufeh Karimi (2579215), Mia Phillipson (305557), Evelina Vågesjö (2579212), Stefan Roos (222800)   +6 more
core   +1 more source

Effects of medium-chain fatty acids on the structure and immune response of IPEC-J2 cells [PDF]

Cytotechnology, 2016
Medium-chain fatty acids (MCFAs) have been suggested as an alternative to the use of antibiotics in animal nutrition with promising results. First, we studied the sensitivity of Salmonella Enteritidis and an enteropathogenic Escherichia coli strain against caprylic (C8), capric (C10) and lauric (C12) acids.
B. Martínez-Vallespín, W. Vahjen, J. Zentek   +2 more
openaire   +2 more sources

Postbiotics in Food Systems: Components, Production Methods, Food Applications, Functional Properties, and Technological Challenges

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
This review provides a comprehensive, engineering‐oriented synthesis of postbiotics as next‐generation functional food ingredients. It first outlines the principal production routes for postbiotic generation, encompassing thermal technologies, non‐thermal technologies, and extraction/purification methods, and subsequently examines the analytical and ...
Tansu Taspinar, Nuray Güzeler
wiley   +1 more source

PS does not affect junctional protein localization within cell-cell contacts but controls tight junction protein quantity of IPEC-J2.

, 2013
(A) Confocal immunofluorescence images of IPEC-J2/FBS, IPEC-J2/PS, and cryosectioned pig jejunal mucosae. Cldn5, tric, and occl are presented in green, counterstain in red, as indicated. Nuclei are presented in blue (DAPI).
Juliane Rieger (485685), Silke S. Zakrzewski (485681), In-Fah M. Lee (485684), Jan F. Richter (485682), Susanne M. Krug (181168), Jörg D. Schulzke (354049), Britta Jebautzke (485683), Monika Sachtleben (485686), Angelika Bondzio (430493), Michael Fromm (23852), Dorothee Günzel (208959)   +10 more
core   +1 more source

Transport of Surface Engineered Polyamidoamine (PAMAM) Dendrimers Across IPEC-J2 Cell Monolayers [PDF]

Drug Delivery, 2008
The aim of our study was to prepare arginine-and ornithine-conjugated Polyamidoamine (PAMAM) dendrimers and study their permeability across IPEC-J2 cell monolayers, a new intestinal cell line model for drug absorption studies. Arginine and ornithine were conjugated to the amine terminals of the PAMAM(G4) dendrimers by Fmoc synthesis.
Dipak S, Pisal, Venkata K, Yellepeddi, Ajay, Kumar, Srinath, Palakurthi   +3 more
openaire   +2 more sources

Equol Alleviates Postmenopausal Metabolic Dysfunction‐Associated Steatotic Liver Disease via the GPR30/PI3K Pathway

eFood, Volume 7, Issue 3, June 2026.
This study demonstrates that equol exerts a protective effect on metabolic dysfunction‐associated steatotic liver disease in both in vivo and in vitro by activating the GPR30/PI3K/Nrf2 signaling pathway. Equol's interaction with GPR30 and its ability to activate the PI3K/Nrf2 pathway provide a promising therapeutic strategy for treating metabolic ...
Hanqiang Cui, Bin Wang, Bo Zou, Guiming Zhang, Zhe Xu, Shuo Li, Jing Xu, Xiangmin Ni, Jian Wang   +8 more
wiley   +1 more source