Results 1 to 10 of about 15,094 (184)

Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera [PDF]

Nature Communications
The endoplasmic-reticulum (ER) transmembrane protein IRE1 mitigates ER stress through kinase-endoribonuclease and scaffolding activities. Cancer cells often co-opt IRE1 to facilitate growth.
Jin Du, Elisia Villemure, Matthew Johnson, Caleigh Azumaya, Catarina J. Gaspar, Scot Marsters, David Lawrence, Scott Foster, Alexis Rohou, Tommy K. Cheung, Christopher M. Rose, Thomas Garner, Soo Ro, Kevin Clark, Maureen H. Beresini, Marie-Gabrielle Braun, Joachim Rudolph, Peter Hsu, Avi Ashkenazi   +18 more
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Dietary influences on chemotherapy sensitivity and cardiotoxicity modulated by IRE1 targeting in triple‐negative breast cancer in female mice [PDF]

Physiological Reports
Triple‐negative breast cancer (TNBC) predominantly affects young and minority women, with cytotoxic chemotherapy regimens causing severe side effects, including chronic cardiac dysfunction. Obesity worsens TNBC survival. Inositol‐requiring enzyme‐1 (IRE1)
Yismeilin R. Feliz‐Mosquea, Adam S. Wilson, Nildris Cruz‐Diaz, Valerie S. Payne, Katherine L. Cook, David R. Soto‐Pantoja   +5 more
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Signal sequence-triage is activated by translocon obstruction sensed by an ER stress sensor IRE1α

Cell Structure and Function, 2023
Secretory pathway proteins are cotranslationally translocated into the endoplasmic reticulum (ER) of metazoan cells through the protein channel, translocon.
Ashuei Sogawa, Ryota Komori, Kota Yanagitani, Miku Ohfurudono, Akio Tsuru, Koji Kadoi, Yukio Kimata, Hiderou Yoshida, Kenji Kohno   +8 more
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Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response [PDF]

Open Biology, 2020
Hsp70 chaperones interact with substrate proteins in a coordinated fashion that is regulated by nucleotides and enhanced by assisting cochaperones.
Natacha Larburu, Christopher J. Adams, Chao-Sheng Chen, Piotr R. Nowak, Maruf M. U. Ali   +4 more
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Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia

Pharmaceutical Biology, 2021
Context Icariin (ICA), a flavonol glycoside extracted from Epimedium brevicornum Maxim (Berberidaceae), has been proven to inhibit inflammatory response in ischaemic rats in our laboratory's previous work.
Zhen-Tao Mo, Jie Zheng, Yu-ling Liao
doaj   +1 more source

Classical swine fever virus employs the PERK- and IRE1-dependent autophagy for viral replication in cultured cells.

Virulence, 2021
Endoplasmic reticulum stress (ERS)-mediated autophagy is indispensable for modulation of replication and pathogenesis of numerous mammalian viruses. We have previously shown that classical swine fever virus (CSFV) infection induces ERS-mediated autophagy
Erpeng Zhu, Huawei Wu, Wenxian Chen, Yuwei Qin, Jiameng Liu, Shuangqi Fan, Shengming Ma, Keke Wu, Qian Mao, Chaowei Luo, Yixian Qin, Lin Yi, Hongxing Ding, Mingqiu Zhao, Jinding Chen   +14 more
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Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila

iScience, 2021
Summary: The endoplasmic reticulum (ER)-resident transmembrane protein kinase/RNase Ire1 is a conserved sensor of the cellular unfolded protein response and has been implicated in lipid homeostasis, including lipid synthesis and transport, across species.
Peng Zhao, Ping Huang, Tongfu Xu, Xiaoxiang Xiang, Ying Sun, Jingqi Liu, Cheng Yan, Lei Wang, Jiamei Gao, Shang Cui, Xiangdong Wang, Lixing Zhan, Haiyun Song, Jingnan Liu, Wei Song, Yong Liu   +15 more
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The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress

Scientific Reports, 2021
Upon endoplasmic-reticulum (ER) stress, the ER-located transmembrane protein, Ire1, is autophosphorylated and acts as an endoribonuclease to trigger the unfolded protein response (UPR).
Quynh Giang Le, Yuki Ishiwata-Kimata, Thi Huong Phuong, Shigeto Fukunaka, Kenji Kohno, Yukio Kimata   +5 more
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Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers

eLife, 2022
Protein folding homeostasis in the endoplasmic reticulum (ER) is regulated by a signaling network, termed the unfolded protein response (UPR). Inositol-requiring enzyme 1 (IRE1) is an ER membrane-resident kinase/RNase that mediates signal transmission in
Vladislav Belyy, Iratxe Zuazo-Gaztelu, Andrew Alamban, Avi Ashkenazi, Peter Walter   +4 more
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Protomer alignment modulates specificity of RNA substrate recognition by Ire1

eLife, 2021
The unfolded protein response (UPR) maintains protein folding homeostasis in the endoplasmic reticulum (ER). In metazoan cells, the Ire1 branch of the UPR initiates two functional outputs—non-conventional mRNA splicing and selective mRNA decay (RIDD). By
Weihan Li, Kelly Crotty, Diego Garrido Ruiz, Mark Voorhies, Carlos Rivera, Anita Sil, R Dyche Mullins, Matthew P Jacobson, Jirka Peschek, Peter Walter   +9 more
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