Results 151 to 160 of about 15,094 (184)

Assays to Study IRE1 Activation and Signaling

2022
The endoplasmic reticulum (ER) stress sensor IRE1 is a a major player of the unfolded protein response (UPR), the main pathway driving adaptation processes to restore proteostasis.  In addition, overactivation of IRE1 signaling contributes to a variety of pathologies including diabetes, neurodegenerative diseases, and cancer. Under ER stress, IRE1 auto-
Paloma, Moraga, Raul, Aravena, Hery, Urra, Claudio, Hetz   +3 more
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Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming [PDF]

Nature Chemical Biology, 2020
Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases. However, no pharmacologic activators of this pathway identified to date are suitable for ER proteostasis remodeling through selective activation of IRE1 ...
Evan T Powers, Christina B Cooley, Lars Plate   +2 more
exaly   +3 more sources

Structural and molecular bases to IRE1 activity modulation

Biochemical Journal, 2021
The Unfolded Protein response is an adaptive pathway triggered upon alteration of endoplasmic reticulum (ER) homeostasis. It is transduced by three major ER stress sensors, among which the Inositol Requiring Enzyme 1 (IRE1) is the most evolutionarily conserved.
Timothy Langlais, Diana Pelizzari-Raymundo, Sayyed Jalil Mahdizadeh, Nicolas Gouault, Francois Carreaux, Eric Chevet, Leif A. Eriksson, Xavier Guillory   +7 more
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IRE1 gives weight to obesity-associated inflammation

Nature Immunology, 2017
IRE1α is a stress sensor that is activated by a high-fat diet. In adipose-tissue macrophages, it serves as a major switch toward pro-inflammatory M1 polarization and thereby contributes to obesity and associated diseases.
Bojan Bujisic, Fabio Martinon
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Principles of IRE1 Modulation Using Chemical Tools

2011
Perturbations that derail the proper folding and assembly of proteins in the endoplasmic reticulum (ER) lead to misfolded protein accrual in the ER-a toxic condition known as ER stress. The unfolded protein response (UPR) is a signaling system evolved to detect and rectify ER stress.
Kenneth P K, Lee, Frank, Sicheri
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Hepatic IRE1 Protects Against Septic Cardiac Failure

2023
SUMMARYMetabolic reprogramming in response to infection plays a critical role for septic survival. During a septic episode, the heart heavily relies on hepatic lipid particles to prevent heart damage and failure. Inositol- Requiring Enzyme 1 (IRE1) is the most conserved unfolded protein response (UPR) regulator that governs homeostasis of the ...
Mark Li, Roger R. Berton, Qingwen Qian, J. Alan Maschek, Biyi Chen, Elizabeth Barroso, Adam J. Rauckhorst, Thomas S. Griffith, Eric B. Taylor, Vladimir P. Badovinac, Gökhan S. Hotamisligil, Long-Sheng Song, Ling Yang   +12 more
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IRE1 and efferent signaling from the endoplasmic reticulum

Journal of Cell Science, 2000
ABSTRACT Genetic analysis of the cellular adaptation to malfolded proteins in the endoplasmic reticulum (the unfolded protein response – UPR) has revealed a novel signaling pathway initiated by activation of IRE1, an ER-resident protein kinase and endonuclease.
F, Urano, A, Bertolotti, D, Ron
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Reshaping the Immune Tumor Microenvironment Through IRE1 Signaling

Trends in Molecular Medicine, 2018
The ability of a tumor cell to cope with environmental and intracellular stress depends on its capacity to activate appropriate adaptive pathways. As such, the endoplasmic reticulum (ER) adjusts the adaptive capacity of tumor cells by engaging the unfolded protein response (UPR).
Rubio-Patiño, Camila, Bossowski, Jozef P., Chevet, Eric, Ricci, Jean-Ehrland   +3 more
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Getting RIDD of RNA: IRE1 in cell fate regulation

Trends in Biochemical Sciences, 2014
Inositol-requiring enzyme 1 (IRE1) is the most conserved transducer of the unfolded protein response (UPR), a homeostatic response that preserves proteostasis. Intriguingly, via its endoribonuclease activity, IRE1 produces either adaptive or death signals.
M, Maurel, E, Chevet, J, Tavernier, S, Gerlo   +3 more
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Abstract 2084: Reactive oxygen species activate the IRE1-XBP1 pro-apoptotic pathway by recruiting TRAF2 to IRE1 and activating an IRE1-TRAF2-JNK pathway in human glioma cells

Cancer Research, 2011
Abstract To investigate the function of the oxidative stress in the endoplasmic reticulum (ER) -related cell death of glioma, the human glioma cells were treated with hydrogen peroxide, TNF, and thapsigargin to raise intracellular levels of hydroxyl radical and ER stress, respectively.
Yeon Hyang Kim, Hyung-Kon Koh
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