Results 161 to 170 of about 15,094 (184)
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The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes
Science, 2021Ngoc-Han Tran +2 more
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Pharmacological targeting of Ire1 of Candida albicans
Research Journal of BiotechnologyThe common fungal pathogen Candida albicans primarily affects immunocompromised individuals and the rise in antifungal resistance underscores the urgent need for new treatment options. In this study, we investigate the potential of STF-83010, a human Ire1 inhibitor, as a treatment for candidiasis. Our findings reveal that STF-83010 effectively inhibits
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The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Nature Reviews Molecular Cell Biology, 2012Claudio Hetz
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IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2
Science, 2012Eric S Wang +2 more
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Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response
Science, 2011Peter Walter
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The unfolded protein response signals through high-order assembly of Ire1
Nature, 2008Pascal F Egea +2 more
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Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1
Science, 2006, Ann-Hwee Lee, Gabriel S Brandt
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