Results 31 to 40 of about 15,094 (184)
IRE1α Promotes Zika Virus Infection via XBP1
Viruses, 2020 Zika virus (ZIKV) is an emergent member of the Flaviviridae family which causes severe congenital defects and other major sequelae, but the cellular processes that support ZIKV replication are incompletely understood.
Elena P. Kolpikova +5 more
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OVEREXPRESSION OF DOMINANT-NEGATIVE IRE1 ENZYME IN H1299-shE6AP CELLS INCREASES HEAT SHOCK ELEMENT-DEPENDENT TRANSCRIPTION [PDF]
Biotechnologia Acta, 2015 To investigate IRE1-dependent branch of endoplasmic reticulum stress pathway in various cancer cells we created cDNA-constructs for expression of dominant-negative inositol-requiring enzyme – 1 IRE1 and cytosolic domain of IRE1 fused on a C-terminus with
D. O. , О. H.
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sMEK1 promotes crosstalk between IRE1 and Akt signalling pathways: Evidence for a novel IRE1/sMEK1/Akt complex [PDF]
, 2021 AbstractThe Unfolded Protein Response (UPR) is a dynamic cellular pathway that helps maintain proteostasis during endoplasmic reticulum (ER) stress. One of the key UPR sensors is IRE1, which plays a central role in managing ER stress and interacts with other cellular pathways to regulate cell homeostasis.
Ozaira Qadri +4 more
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Engineering ER-stress dependent non-conventional mRNA splicing
eLife, 2018 The endoplasmic reticulum (ER) protein folding capacity is balanced with the protein folding burden to prevent accumulation of un- or misfolded proteins.
Weihan Li +6 more
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IRE1: ER stress sensor and cell fate executor [PDF]
Trends in Cell Biology, 2013 Cells operate a signaling network termed the unfolded protein response (UPR) to monitor protein-folding capacity in the endoplasmic reticulum (ER). Inositol-requiring enzyme 1 (IRE1) is an ER transmembrane sensor that activates the UPR to maintain the ER and cellular function.
Yani, Chen, Federica, Brandizzi
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In vitro RNA Cleavage Assays to Characterize IRE1-dependent RNA Decay
Bio-Protocol, 2019 The kinase/RNase IRE1 is a key effector of the cellular response to endoplasmic reticulum stress. The RNase activity of IRE1 can be measured in cells or in the test tube.
G. Karagöz +3 more
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CCDC170 affects breast cancer apoptosis through IRE1 pathway
Aging, 2020 Genome-wide association studies have revealed that multiple single-nucleotide polymorphisms in the intergenic region between estrogen receptor 1 and coiled-coil domain containing 170 (CCDC170) are associated with breast cancer risk. We performed microarray and bioinformatics analyses to identify genes that were induced upon CCDC170 overexpression, and ...
Wang, Qiong +8 more
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Inhibition of IRE1 results in decreased scar formation [PDF]
Wound Repair and Regeneration, 2017 AbstractWound healing is characterized by the production of large amounts of protein necessary to replace lost cellular mass and extracellular matrix. The unfolded protein response (UPR) is an important adaptive cellular response to increased protein synthesis.
Tatiana V. Boyko +8 more
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PLoS Biology, 2010 The unfolded protein response (UPR) is an intracellular signaling pathway that counteracts variable stresses that impair protein folding in the endoplasmic reticulum (ER). As such, the UPR is thought to be a homeostat that finely tunes ER protein folding
David Pincus +6 more
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eLife, 2014 Insufficient protein-folding capacity in the endoplasmic reticulum (ER) induces the unfolded protein response (UPR). In the ER lumen, accumulation of unfolded proteins activates the transmembrane ER-stress sensor Ire1 and drives its oligomerization.
Eelco van Anken +8 more
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