Results 41 to 50 of about 15,094 (184)

Enteroviruses Manipulate the Unfolded Protein Response through Multifaceted Deregulation of the Ire1-Xbp1 Pathway

Viruses, 2022
Many viruses are known to trigger endoplasmic reticulum (ER) stress in host cells, which in turn can develop a protective unfolded protein response (UPR). Depending on the conditions, the UPR may lead to either cell survival or programmed cell death. One
Anna Shishova, Ilya Dyugay, Ksenia Fominykh, Victoria Baryshnikova, Alena Dereventsova, Yuriy Turchenko, Anna A. Slavokhotova, Yury Ivin, Sergey E. Dmitriev, Anatoly Gmyl   +9 more
doaj   +1 more source

Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1

BMC Biology, 2011
Background Ire1 is a signal transduction protein in the endoplasmic reticulum (ER) membrane that serves to adjust the protein-folding capacity of the ER according to the needs of the cell.
Stroud Robert M, Finer-Moore Janet, Korostelev Andrei A, Egea Pascal F, Korennykh Alexei V, Zhang Chao, Shokat Kevan M, Walter Peter   +7 more
doaj   +1 more source

Cytomegalovirus downregulates IRE1 to repress the unfolded protein response. [PDF]

PLoS Pathogens, 2013
During viral infection, a massive demand for viral glycoproteins can overwhelm the capacity of the protein folding and quality control machinery, leading to an accumulation of unfolded proteins in the endoplasmic reticulum (ER). To restore ER homeostasis,
Sebastian Stahl, Julia M Burkhart, Florian Hinte, Boaz Tirosh, Hermine Mohr, René P Zahedi, Albert Sickmann, Zsolt Ruzsics, Matthias Budt, Wolfram Brune   +9 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Ubiquitination of Inositol-requiring Enzyme 1 (IRE1) by the E3 Ligase CHIP Mediates the IRE1/TRAF2/JNK Pathway [PDF]

Journal of Biological Chemistry, 2014
Deciphering the inositol-requiring enzyme 1 (IRE1) signaling pathway is fundamentally important for understanding the unfolded protein response (UPR). The ubiquitination of proteins residing on the endoplasmic reticulum (ER) membrane has been reported to be involved in the UPR, although the mechanism has yet to be fully elucidated.
Xu, Zhu, Ju, Zhang, Huiying, Sun, Cuicui, Jiang, Yusheng, Dong, Qiang, Shan, Siyuan, Su, Yingying, Xie, Ningzhi, Xu, Xiaomin, Lou, Siqi, Liu   +10 more
openaire   +2 more sources

Effects of Ire1 gene on virulence and pathogenicity of Candida albicans

Open Life Sciences
With the extensive utilization of antifungal drugs, the drug resistance of Candida albicans is progressively intensifying, and the effect of empirical treatment for C. albicans infection is not evident.
Zhao Huihai, Qin Lixia, Li Mengyan, Jiang Mengyu, Cui Mengge, Wang Hua, Hou Baohua, Wang Fukun, Jia Keran   +8 more
doaj   +1 more source

Possible Involvement of X-Box Binding Protein-1 in the Onset of Pulpitis

European Endodontic Journal
Objective: Endoplasmic reticulum (ER) stress plays important roles not only in stress avoidance, but also in cell differentiation and maturation, cell proliferation, and promotion of bone formation.
Tomoya Naruse, Katsuhiro Takeda, Kazuma Yoshida, Shinya Sasaki, Tomoki Kumagai, Yohei Takahashi, Reina Kawai, Jun Nakanishi, Hideki Shiba   +8 more
doaj   +1 more source

RNA sequencing identifies novel regulated IRE1-dependent decay targets that affect multiple myeloma survival and proliferation

Experimental Hematology & Oncology, 2022
Background IRE1 is an unfolded protein response (UPR) sensor with kinase and endonuclease activity. It plays a central role in the endoplasmic reticulum (ER) stress response through unconventional splicing of XBP1 mRNA and regulated IRE1-dependent decay (
Dalia Quwaider, Luis A. Corchete, Marta Martín-Izquierdo, Jesús M. Hernández-Sánchez, Elizabeta A. Rojas, Ignacio J. Cardona-Benavides, Ramón García-Sanz, Ana B. Herrero, Norma C. Gutiérrez   +8 more
doaj   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Marburg virus regulates the IRE1/XBP1-dependent unfolded protein response to ensure efficient viral replication

Emerging Microbes and Infections, 2019
Viruses regulate cellular signalling pathways to ensure optimal viral replication. During Marburg virus (MARV) infection, large quantities of the viral glycoprotein GP are produced in the ER; this may result in the activation of the unfolded protein ...
Cornelius Rohde, Stephan Becker, Verena Krähling   +2 more
doaj   +1 more source