Results 91 to 100 of about 81,945 (302)

Lost and found in translation: the value of the human imiquimod model

British Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs, Juliette A. van den Noort, Salma Assil, Naomi B. Klarenbeek, Matthijs Moerland, Tessa Niemeyer‐van der Kolk, Robert Rissmann   +6 more
wiley   +1 more source

Modeling and Analysis Data Production of Oil, and Oil and Gas in Indonesia by Using Threshold Vector Error Correction Model

Science and Technology Indonesia
Data in the fields of finance, business, economics, agriculture, the environment and weather are commonly in the form of time series data. To analyze time series data that involves more than one variable (multivariate), vector autoregressive (VAR) models,
Widiarti, Mustofa Usman, Almira Rizka Putri, Edwin Russel   +3 more
doaj   +1 more source

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

, 1993
Interferon regulatory factor 1 (IRF-1), a transcriptional activator, and its antagonistic repressor, IRF-2, were originally identified as regulators of the type I interferon (IFN) system.
Watanabe, Nobumasa, Kündig, Thomas M., Potter, Julia, Wakeham, Andrew, Narendran, Arumugavadivel, Ohashi, Pamela S., Kitagawa, Motoo, Paige, Christopher J., Matsuyama, Toshifumi, Pfeffer, Klaus, Furlonger, Caren L., Suzuki, Haruhiko, Taniguchi, Tadatsugu, Mak, Tak W., Kishihara, Kenji, Amakawa, Ryuichi, Kimura, Tohru, Kawakami, Takatoshi   +17 more
core   +1 more source

Innovation Pathways to Carbon Efficiency: Disentangling the Effects of AI, R&D, and Clean Energy Blessings on U.S. Environmental Sustainability

Business Strategy and the Environment, EarlyView.
ABSTRACT The United States (U.S.) faces challenges in achieving its ambitious net‐zero carbon emissions target by 2050, with current emissions having fallen by less than 1% in 2024. Despite an investment of $500 billion in low‐carbon resources while holding the second‐largest green technology patent portfolio globally, it is further imperative to ...
Md Zubair Ahmad, Jewel Rana, Mohammad Fakhrul Islam, Md Nazmul Islam Jihad, Md. Rashed, Md. Kamal Uddin   +5 more
wiley   +1 more source

IRF-E on the RIG-I promoter regulates the transcriptional activity of RIG-I.

, 2016
(A) Putative consensus sequences of ISRE, GAS and IRF-E within the proximal region of the RIG-I promoter are shown. (B) A series of single (double or triple) deletion constructs on the RIG-I promoter is shown.
Tadaatsu Imaizumi (134869), Tomoh Matsumiya (134862), Fei Xing (134861), Ryo Hayakari (134865), Hidemi Yoshida (134872), Makoto Hayakari (3134937)   +5 more
core   +1 more source

Environmental Management Accounting in Private Hospitals: Navigating Competing Strategic Priorities for Sustainable Decision‐Making

Business Strategy and the Environment, EarlyView.
ABSTRACT Environmental management accounting (EMA) is increasingly recognised as essential for carbon governance, accountability and net zero transitions, yet research has overlooked how sustainability is negotiated within mission‐driven but commercially exposed service organisations such as private hospitals in developing economies, a sector often ...
M. M. Swalih, Ronita Ram, Edward Tew
wiley   +1 more source

Intracellular localization of IRF-1 and IRF-3.

, 2016
(A) HeLa cells were subjected to the following treatments: control (a-c, j-l), transfected with poly I:C (100 ng, for 4 h) (d-f, m-o), or treated with IFN-γ (2 ng/mL, for 4 h) (g-i, p-r).
Tadaatsu Imaizumi (134869), Tomoh Matsumiya (134862), Fei Xing (134861), Ryo Hayakari (134865), Hidemi Yoshida (134872), Makoto Hayakari (3134937)   +5 more
core   +1 more source

Long Fluorescence Lifetime Molecular Rotors Based on the 4,4‐Dicyano‐BODIPY Core

Chemistry – A European Journal, EarlyView.
Substituting fluorine with cyano groups in BODIPY‐based fluorescent molecular rotors yields viscosity‐sensitive dyes with significantly enhanced fluorescence lifetimes that can be used for viscosity mapping in living cells using FLIM microscopy. ABSTRACT Environmentally sensitive fluorescent probes with extended emission lifetimes are highly valuable ...
Yelyzaveta Denysieva, Ludovic Richert, Yves Mély, Julie Karpenko, Dmytro Dziuba   +4 more
wiley   +1 more source

Red Blood Cell Surface Proteins and Cryopreservation for Tracking Altered Erythropoiesis

Drug Testing and Analysis, EarlyView.
Recombinant human erythropoietin altered red blood cell surface protein expression, but responses were inconsistent and accompanied by substantial baseline variability. Although cryopreservation reduced analytical variability, it did not improve biomarker performance, indicating limited utility for detecting altered erythropoiesis. ABSTRACT The present
Martin Thomassen, Thomas Bonne, Jonathan Graae, Sophie Møller, Ylva Hellsten, Henrik Sørensen, Nikolai B. Nordsborg, Jacob Bejder   +7 more
wiley   +1 more source

IRF- 1 and IRF-4 Regulate Target Gene Expression via Interaction with DMP 1 [PDF]

Interferon regulatory factor-4 (IRF-4), a member of the IRF gene family, is a lymphoid-specific transcription factor. IRF-4 deficient mice showed severe immunodeficiencies.
Yamamoto, Kazuo, Kohno, Tomoko, Yamamoto, Yuuichi, Matsuyama, Toshifumi, Nogi, Yasuhisa, Yoshida, Kayo   +5 more
core   +1 more source