Results 11 to 20 of about 81,945 (302)

The Cell Cycle Control Element of Histone H4 Gene Transcription Is Maximally Responsive to Interferon Regulatory Factor Pairs IRF-1/IRF-3 and IRF-1/IRF-7 [PDF]

Journal of Biological Chemistry, 2001
Interferon regulatory factors (IRFs) are transcriptional mediators of interferon-responsive signaling pathways that are involved in antiviral defense, immune response, and cell growth regulation. To investigate the role of IRF proteins in the regulation of histone H4 gene transcription, we compared the transcriptional contributions of IRF-1, IRF-2, IRF-
Xie, Ronglin, Van Wijnen, Andre J., van der Meijden, Caroline M. J., Luong, Mai X., Stein, Janet L., Stein, Gary S.   +5 more
openaire   +4 more sources

Identification of IRF-8 and IRF-1 target genes in activated macrophages [PDF]

Molecular Immunology, 2007
Interferon regulatory factor 1 (IRF-1) and IRF-8, also known as interferon consensus sequence binding protein (ICSBP), are important regulators of macrophage differentiation and function. These factors exert their activities through the formation of heterocomplexes. As such, they are coactivators of various interferon-inducible genes in macrophages. To
Dror, Natalie, Alter-Koltunoff, Michal, Azriel, Aviva, Amariglio, Ninette, Jacob-Hirsch, Jasmine, Zeligson, Sharon, Morgenstern, Avigail, Tamura, Tomohiko, Hauser, Hansjörg, Rechavi, Gideon, Ozato, Keiko, Levi, Ben-Zion   +11 more
openaire   +5 more sources

Global characterization of interferon regulatory factor (IRF) genes in vertebrates: Glimpse of the diversification in evolution [PDF]

BMC Immunology, 2010
Background Interferon regulatory factors (IRFs), which can be identified based on a unique helix-turn-helix DNA-binding domain (DBD) are a large family of transcription factors involved in host immune response, haemotopoietic differentiation and ...
Xu Zhen, Qi Zhi T, Huang Bei, Nie Pin
doaj   +2 more sources

Ad-IRF-1 Induces Apoptosis in Esophageal Adenocarcinoma

Neoplasia: An International Journal for Oncology Research, 2006
The nuclear transcription factor interferon regulatory factor-1 (IRF-1) is a putative tumor suppressor, but the expression and function of IRF-1 in esophageal adenocarcinoma (EA) remain unknown.
Gregory A. Watson, Pierre E. Queiroz de Oliveira, Michael T. Stang, Michaele J. Armstrong, William E. Gooding, Shih-Fan Kuan, John H. Yim, Steven J. Hughes   +7 more
doaj   +2 more sources

IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling [PDF]

PLoS Pathogens, 2013
Although the transcription factors IRF-3 and IRF-7 are considered master regulators of type I interferon (IFN) induction and IFN stimulated gene (ISG) expression, Irf3-/-×Irf7-/- double knockout (DKO) myeloid dendritic cells (mDC) produce relatively normal levels of IFN-β after viral infection. We generated Irf3-/-×Irf5-/-×Irf7-/- triple knockout (TKO)
Lazear, Helen M, Lancaster, Alissa, Wilkins, Courtney, Suthar, Mehul S, Huang, Albert, Vick, Sarah C, Clepper, Lisa, Thackray, Larissa, Brassil, Margaret M, Virgin, Herbert W, Nikolich-Zugich, Janko, Moses, Ashlee V, Gale, Michael, Jr., Fruh, Klaus, Diamond, Michael S   +14 more
core   +8 more sources

Fighting for their survival

Pachyderm, 2021
The International Rhino Foundation (IRF), based in the United States operates on-the-ground programmes in Africa and Asia where rhinos live in the wild, supporting viable populations of the five remaining rhino species and the communities that coexist ...
Christopher Whitlatch for IRF
doaj   +1 more source

Towards a user-oriented adaptive system based on sentiment analysis from text [PDF]

E3S Web of Conferences, 2021
Sentiment analysis has known a big interest over recent years due to the expansion of data. It has many applications in different fields such as marketing, psychology, human-computer interaction, eLearning, etc. There are many forms of sentiment analysis,
Baqach Adil, Battou Amal
doaj   +1 more source

PRINCIPAL COMPONENT ANALYSIS-VECTOR AUTOREGRESSIVE INTEGRATED (PCA-VARI) MODEL USING DATA MINING APPROACH TO CLIMATE DATA IN THE WEST JAVA REGION

Barekeng, 2022
Over a long time, atmospheric changes have been caused by natural phenomena. This study uses the Principal Component Analysis (PCA) model combined with Vector Autoregressive Integrated (VARI) called the PCA-VARI model through the data mining approach ...
Devi Munandar, Budi Nurani Ruchjana, Atje Setiawan Abdullah   +2 more
doaj   +1 more source

Utility of reticulocyte indices in the diagnosis of pancytopenia

Journal of Family Medicine and Primary Care, 2022
Introduction: Pancytopenia is a hematological condition in which there is a reduction in all three cell lines of blood. This study aims to evaluate the utility of reticulocyte indices such as reticulocyte % (retic %), immature reticulocyte fraction (IRF),
Jonali Das, Yookarin Khonglah, Iadarilang Tiewsoh, Zachariah Chowdhury, Himesh Barman   +4 more
doaj   +1 more source

Magnetospheric solitary structure maintained by 3000 km/s ions as a cause of westward moving auroral bulge at 19 MLT [PDF]

Annales Geophysicae, 2009
In the evening equatorial magnetosphere at about 4 RE geocentric distance and 19 MLT, the four Cluster spacecraft observed a solitary structure with a width of about 1000~2000 km in the propagation direction.
M. Yamauchi, I. Dandouras, I. Dandouras, P. W. Daly, G. Stenberg, H. U. Frey, P.-A. Lindqvist, Y. Ebihara, H. Nilsson, R. Lundin, H. Rème, H. Rème, M. André, E. A. Kronberg, A. Balogh, M. Henderson   +15 more
doaj   +1 more source