Results 11 to 20 of about 19,243 (300)
FNDC5/Irisin: Physiology and Pathophysiology [PDF]
Molecules, 2022 A sedentary lifestyle or lack of physical activity increases the risk of different diseases, including obesity, diabetes, heart diseases, certain types of cancers, and some neurological diseases.
Rashid Waseem +9 more
semanticscholar +4 more sources
Role of irisin in physiology and pathology
Frontiers in Endocrinology, 2022 Irisin, out-membrane part of fibronectin type III domain–containing 5 protein (FNDC5), was activated by Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) during physical exercise in skeletal muscle tissues.
Shiqiang Liu +6 more
semanticscholar +4 more sources
Expression and Function of Synthetic Dimeric Exercise-Induced Cytokine Irisin-Irisin
康复学报, 2023 ObjectiveStudies have shown that the exercise-induced cytokine Irisin functions were as a dimer, so tandem Irisin-Irisin mock dimers were designed to explore the similarities and differences between recombinant Irisin-Irisin expressed by Escherichia coli
LIU Fengying +5 more
doaj +2 more sources
Progress and Challenges in the Biology of FNDC5 and Irisin [PDF]
Endocrine Reviews, 2021 In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to be expressed in skeletal muscle, heart, and brain. It was virtually ignored for 10 years, until a study in 2012 proposed that, in response to exercise, the ectodomain of ...
S. Maak +3 more
semanticscholar +6 more sources
Molecular Metabolism, 2020 Objective: Considerable uncertainty remains regarding the veracity of measuring myokine irisin more than seven years after its original description. Unresolved issues include the nature of transcription of the irisin precursor fibronectin type III domain
Elke Albrecht +6 more
doaj +5 more sources
Irisin and the therapeutic benefits of exercise [PDF]
BMC Proceedings, 2012 We are experiencing a worldwide epidemic of obesity and type II diabetes. Our group has been interested in the development of both white and brown fat, particularly at the level of gene transcription. PGC1α was first described as a coactivator of PPARγ in the control of brown fat-mediated thermogenesis.
Bruce M. Spiegelman +1 more
openalex +5 more sources
Is Irisin an Anticarcinogenic Peptide?
Medicine Science | International Medical Journal, 2014 Prostate cancer is the most common type of cancer in males. There has been currently no therapy to cure various types of cancer, and hence, studies aiming to develop cancer treatment are important and have been ongoing. Irisin is a hormone, which regulates body weight and metabolism, including insulin resistance and is thought to have beneficial ...
Suat Tekin +3 more
openalex +5 more sources
Irisin—A Pancreatic Islet Hormone [PDF]
Biomedicines, 2022 Irisin is a myokine involved in glucose homeostasis. It is primarily expressed in skeletal muscle, but also in the pancreas. This study aimed to elucidate its presence and role in the islets of Langerhans—i.e., its effect on insulin and glucagon secretion as well as on blood flow in the pancreas.
Daniel Norman +3 more
openaire +4 more sources
Irisin in Liver Cirrhosis [PDF]
Journal of Clinical Medicine, 2020 Background: Sarcopenia is a prevalent muscle abnormality characterized by progressive and generalized loss of skeletal muscle mass and strength, common among patients with decompensated advanced chronic liver disease (dACLD). Irisin is a recently identified myokine, which is mainly expressed and secreted by skeletal muscle.
Michał Kukla +12 more
openaire +4 more sources
Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy
Cells, 2021 Irisin is a myokine derived from the cleavage of fibronectin type III domain-containing 5. Irisin regulates mitochondrial energy, glucose metabolism, fatty acid oxidation, and fat browning.
Ming-Yun Ho, Chao-Yung Wang
doaj +1 more source