Results 11 to 20 of about 5,686 (117)
Irisin in Liver Cirrhosis [PDF]
Journal of Clinical Medicine, 2020 Background: Sarcopenia is a prevalent muscle abnormality characterized by progressive and generalized loss of skeletal muscle mass and strength, common among patients with decompensated advanced chronic liver disease (dACLD). Irisin is a recently identified myokine, which is mainly expressed and secreted by skeletal muscle.
Michał Kukla +11 more
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International Journal of Endocrinology, 2013 In January 2012, Boström and colleagues identified a new muscle tissue secreted peptide, which they named irisin, to highlight its role as a messenger that comes from skeletal muscle to other parts of the body. Irisin is a cleaved and secreted fragment of FNDC5 (also known as FRCP2 and PeP), a member of fibronectin type III repeat containing gene ...
Marta G. Novelle +4 more
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Irisin—A Pancreatic Islet Hormone [PDF]
Biomedicines, 2022 Irisin is a myokine involved in glucose homeostasis. It is primarily expressed in skeletal muscle, but also in the pancreas. This study aimed to elucidate its presence and role in the islets of Langerhans—i.e., its effect on insulin and glucagon secretion as well as on blood flow in the pancreas.
Daniel Norman +3 more
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Irisin: ‘fat’ or artefact [PDF]
Clinical Endocrinology, 2014 SummarySoon after the discovery of the muscle‐derived factor irisin, a great controversy arose in the literature regarding certain inconsistencies in the regulation of the fibronectin type III domain containing 5 protein (FNDC5/irisin) after exercise, as well as the unpredicted association of circulating irisin levels with parameters of adiposity in ...
Crujeiras Martínez, Ana Belén +2 more
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Irisin and Autophagy: First Update [PDF]
International Journal of Molecular Sciences, 2020 Aging and sedentary life style are considered independent risk factors for many disorders. Under these conditions, accumulation of dysfunctional and damaged cellular proteins and organelles occurs, resulting in a cellular degeneration and cell death. Autophagy is a conserved recycling pathway responsible for the degradation, then turnover of cellular ...
Pesce M. +5 more
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Diabetes, 2014 Increasing energy expenditure is an attractive approach to fighting the worldwide epidemic in obesity and type 2 diabetes. Exercise is an important component of good health and represents the first line of therapy for humans with a variety of metabolic disorders: obesity, diabetes, and nonalcoholic hepatic steatosis. Recent data has shown that exercise,
Wu, Jun, Spiegelman, Bruce
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FNDC5/Irisin: Physiology and Pathophysiology [PDF]
Molecules, 2022 A sedentary lifestyle or lack of physical activity increases the risk of different diseases, including obesity, diabetes, heart diseases, certain types of cancers, and some neurological diseases. Physical exercise helps improve quality of life and reduces the risk of many diseases. Irisin, a hormone induced by exercise, is a fragmented product of FNDC5
Rashid Waseem +9 more
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Irisin, Exercise, and COVID-19
Frontiers in Endocrinology, 2022 Muscle and adipose tissue produce irisin during exercise. Irisin is thermogenic adipomyokine, improves glucose and lipid metabolism, and ameliorates the effects of obesity-driven inflammation, metabolic syndrome, and diabetes. In addition, exercise-induced irisin activates anti-inflammatory pathways and may play an essential role in improving the ...
Hugo Rodrigues Alves +5 more
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Molecular Metabolism, 2020 Considerable uncertainty remains regarding the veracity of measuring myokine irisin more than seven years after its original description. Unresolved issues include the nature of transcription of the irisin precursor fibronectin type III domain containing 5 (FNDC5) gene across species, the reliability of irisin levels measured with commercial enzyme ...
Elke Albrecht +6 more
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Irisin deficiency disturbs bone metabolism [PDF]
Journal of Cellular Physiology, 2020 Abstract Balancing the process of bone formation and resorption is important in the maintenance of healthy bone. Therefore, the discovery of novel factors that can regulate bone metabolism remains needed. Irisin is a newly identified hormone‐like peptide. Recent studies have reported the involvement of irisin in many physiological and
Xiaofang Zhu +8 more
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