Results 21 to 30 of about 6,991 (174)

Exploring the role of esketamine in alleviating depressive symptoms in mice via the PGC-1α/irisin/ERK1/2 signaling pathway

Scientific Reports, 2023
Esketamine provides an immediate and noticeable antidepressant effect, although the underlying molecular processes are yet unclear. Irisin induced by aerobic exercise has been implicated in the alleviation of depressive symptoms, whether irisin ...
Na Hu, Xuemei Chen, Chengchuan Chen, Xing Liu, Peng Yi, Tianhao Xu, Jing Jia, Jianguo Feng, Chunxiang Zhang, Xiaobin Wang   +9 more
doaj   +1 more source

Irisin regulates cardiac physiology in zebrafish.

PLoS ONE, 2017
Irisin is a myokine encoded in its precursor fibronectin type III domain containing 5 (FNDC5). It is abundantly expressed in cardiac and skeletal muscle, and is secreted upon the activation of peroxisome proliferator-activated receptor gamma coactivator ...
Lakshminarasimhan Sundarrajan, Chanel Yeung, Logan Hahn, Lynn P Weber, Suraj Unniappan   +4 more
doaj   +1 more source

Irisin deficiency disturbs bone metabolism [PDF]

Journal of Cellular Physiology, 2020
Abstract Balancing the process of bone formation and resorption is important in the maintenance of healthy bone. Therefore, the discovery of novel factors that can regulate bone metabolism remains needed. Irisin is a newly identified hormone‐like peptide. Recent studies have reported the involvement of irisin in many physiological and
Xiaofang Zhu, Xiangfen Li, Xiaoxuan Wang, Ting Chen, Fengjuan Tao, Chuanju Liu, Qisheng Tu, Guofang Shen, Jake J. Chen   +8 more
openaire   +2 more sources

Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling

Frontiers in Physiology, 2019
Irisin is an exercise-induced myokine known to induce adipocyte browning through induction of uncoupling protein 1. Recent studies have reported that irisin is also an adipokine.
Eun Bi Ma, Namood E. Sahar, Moonsup Jeong, Joo Young Huh   +3 more
doaj   +1 more source

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts. [PDF]

PLoS ONE, 2015
Exercise offers short-term and long-term health benefits, including an increased metabolic rate and energy expenditure in myocardium. The newly-discovered exercise-induced myokine, irisin, stimulates conversion of white into brown adipocytes as well as ...
Chao Xie, Yuan Zhang, Tran D N Tran, Hai Wang, Shiwu Li, Eva Vertes George, Haoyang Zhuang, Peilan Zhang, Avi Kandel, Yimu Lai, Dongqi Tang, Westley H Reeves, Henrique Cheng, Yousong Ding, Li-Jun Yang   +14 more
doaj   +1 more source

Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis

Frontiers in Pharmacology, 2019
ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treated ...
Hong Li, Hong Li, Jing Shen, Jing Shen, Tong Wu, Tong Wu, Jiangying Kuang, Jiangying Kuang, Qinhui Liu, Shihai Cheng, Shihai Cheng, Shiyun Pu, Shiyun Pu, Lei Chen, Lei Chen, Rui Li, Rui Li, Yanping Li, Yanping Li, Min Zou, Zhiyong Zhang, Wei Jiang, Aijuan Qu, Jinhan He, Jinhan He   +24 more
doaj   +1 more source

Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects. [PDF]

PLoS ONE, 2015
A physically active life-style plays an independent role in the protection against type 2 diabetes and cardiovascular diseases. Irisin, a novel exercise-induced myokine, activates thermogenesis in rodents through increasing beige fat cells abundance ...
María Moreno, José María Moreno-Navarrete, Marta Serrano, Francisco Ortega, Elías Delgado, Cecilia Sanchez-Ragnarsson, Sergio Valdés, Patricia Botas, Wifredo Ricart, José Manuel Fernández-Real   +9 more
doaj   +1 more source

Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice

Clinical and Translational Medicine, 2020
Background Sepsis remains a major health issue without an effective therapy. Ferroptosis, an iron‐dependent programmed cell death, has been proposed to be related to the pathogenesis of sepsis.
Shasha Wei, Jianbin Bi, Lifei Yang, Jia Zhang, Yafeng Wan, Xue Chen, Yawen Wang, Zheng Wu, Yi Lv, Rongqian Wu   +9 more
doaj   +1 more source

Irisin, Energy Homeostasis and Male Reproduction [PDF]

Frontiers in Physiology, 2021
Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain-containing protein 5 (FNDC5). It is involved in the browning of white adipose tissue, glucose tolerance, and reversing of metabolic disruptions.
Pallav Sengupta, Sulagna Dutta, Ivan Rolland Karkada, Roland Eghoghosoa Akhigbe, Roland Eghoghosoa Akhigbe, Suresh V. Chinni   +5 more
openaire   +3 more sources

Salivary and serum irisin in healthy adults before and after exercise

European Journal of Translational Myology, 2023
Irisin is an exercise-induced cytokine mainly secreted by myocytes. Circulating level of irisin can increase in response to acute exercise, promoting pleiotropic effects on health.
Sara Missaglia, Ester Tommasini, Paola Vago, Claudio Pecci, Christel Galvani, Andrea Silvestrini, Alvaro Mordente, Daniela Tavian   +7 more
doaj   +1 more source