Results 21 to 30 of about 5,686 (117)

Irisin, Energy Homeostasis and Male Reproduction [PDF]

Frontiers in Physiology, 2021
Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain-containing protein 5 (FNDC5). It is involved in the browning of white adipose tissue, glucose tolerance, and reversing of metabolic disruptions.
Pallav Sengupta, Sulagna Dutta, Ivan Rolland Karkada, Roland Eghoghosoa Akhigbe, Roland Eghoghosoa Akhigbe, Suresh V. Chinni   +5 more
openaire   +3 more sources

Expression and Function of Synthetic Dimeric Exercise-Induced Cytokine Irisin-Irisin

Rehabilitation Medicine, 2023
ObjectiveStudies have shown that the exercise-induced cytokine Irisin functions were as a dimer, so tandem Irisin-Irisin mock dimers were designed to explore the similarities and differences between recombinant Irisin-Irisin expressed by Escherichia coli and commercial Irisin in activity and function on tumor cells.MethodsEscherichia coli strain BL21 ...
LIU Fengying, HUANG Yide, LIN Jia, CHEN Xuequn, WANG Qingshui, LIN Yao   +5 more
openaire   +2 more sources

Egzersiz, İrisin ve Obezite

Gaziantep Üniversitesi Spor Bilimleri Dergisi, 2022
Gelişmiş ve gelişmekte olan ülkelerdeki şehir hayatının hareketsiz yaşamı, besinsel ürünlere kolay ulaşabilmeyi ve fas food kültürünü yaygınlaştırdığı görülmektedir. Yeni yaşam tarzı hem halk sağlığını tehdit etmekte hem de sistemik metabolik fonksiyon bozukluklarına kılavuzluk ederek obezite gibi hastalıkların yaygınlaşmasına neden olmaktadır.
Salih ÖNER, Yavuz YASUL
openaire   +3 more sources

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Irisin – der neue Schlankmacher?

, 2013
Einleitung: Irisin ist ein Hormon, welches vom Muskel infolge von Aktivität ausschüttet wird. Beschrieben ist eine direkte Wirkung auf das Fettgewebe, da Irisin die Transdifferenzierung von weißem zu braunem Fettgewebe stimuliert. Aufgrund dieser Erkenntnis bestand die Frage, ob Irisin[for full text, please go to the a.m. URL]
Schäfer, B, Hemmrich, K, Paul, N, Fehsel, K, Pallua, N   +4 more
openaire   +2 more sources

Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review

Obesity Reviews, EarlyView.
ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Nayra Figueiredo, Fabiana Kattah, Cintia Cercato, Lian Tock, Raquel Munhoz da Silveira Campos   +7 more
wiley   +1 more source

Disordered metabolism in mice lacking irisin [PDF]

Scientific Reports, 2020
AbstractIrisin is a product of fibronectin type III domain-containing protein (Fndc5) and is involved in the regulation of adipokine secretion and the differentiation of osteoblasts and osteoclasts. In this study, we aimed to determine whether irisin lacking affects glucose/lipid and bone metabolism.
Luo, Yunyao, Qiao, Xiaoyong, Ma, Yaxian, Deng, Hongxia, Xu, Charles C., Xu, Liangzhi   +5 more
openaire   +2 more sources

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

Experimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti, Bergita Ganse, Nicola A. Maffiuletti, Rob C. I. Wüst, Gustav J. Strijkers, Andy Sanderson, Hans Degens   +6 more
wiley   +1 more source

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source