Results 31 to 40 of about 6,991 (174)

Dose-dependent tandem responses of osteoblasts during osteogenesis

Medicine in Novel Technology and Devices, 2023
Irisin, a myokine mainly secreted from contracted skeleton muscle, plays a profound role in bone formation and remodeling. Although irisin has been revealed to elevate bone mass in vivo, details whether there is a dose-dependent relationship between ...
Yuwei Zhang, Lizhen Wang, Hongyan Kang, Chia-Ying Lin, Yubo Fan   +4 more
doaj   +1 more source

Expression, purification and biological characterisation of recombinant human irisin (12.5 kDa)

Journal of Genetic Engineering and Biotechnology, 2018
Fibronectin type III domain containing 5 (FNDC5) is a transmembrane protein. Upon cleavage, it yields a peptide called irisin that is supposedly bind to an unknown receptor and facilitates browning of white adipose tissue (WAT).
Kalpana Panati, Venkata Ramireddy Narala, Vydyanath R. Narasimha, Madhavi Derangula, Venkat R.R. Arva Tatireddigari, Suneetha Yeguvapalli   +5 more
doaj   +1 more source

Role of irisin in Chinese patients with hypothyroidism: an interventional study

Journal of International Medical Research, 2019
Objective Irisin is a myokine that greatly affects energy expenditure and systemic metabolism. While thyroid hormone is likely associated with irisin, a direct relationship remains to be fully elucidated.
Ning Yang, Heng Zhang, Xia Gao, Li Miao, Zhi Yao, Yuan Xu, Guang Wang   +6 more
doaj   +1 more source

Egzersiz, İrisin ve Obezite

Gaziantep Üniversitesi Spor Bilimleri Dergisi, 2022
Gelişmiş ve gelişmekte olan ülkelerdeki şehir hayatının hareketsiz yaşamı, besinsel ürünlere kolay ulaşabilmeyi ve fas food kültürünü yaygınlaştırdığı görülmektedir. Yeni yaşam tarzı hem halk sağlığını tehdit etmekte hem de sistemik metabolik fonksiyon bozukluklarına kılavuzluk ederek obezite gibi hastalıkların yaygınlaşmasına neden olmaktadır.
Salih ÖNER, Yavuz YASUL
openaire   +3 more sources

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

eLife, 2020
Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In this study, we investigated whether irisin directly regulates osteoclasts.
Eben G Estell, Phuong T Le, Yosta Vegting, Hyeonwoo Kim, Christiane Wrann, Mary L Bouxsein, Kenichi Nagano, Roland Baron, Bruce M Spiegelman, Clifford J Rosen   +9 more
doaj   +1 more source

Irisin inhibits pancreatic cancer cell growth via the AMPK-mTOR pathway

Scientific Reports, 2018
Irisin, a recently identified myokine that is released from skeletal muscle following exercise, regulates body weight and influences various metabolic diseases such as obesity and diabetes.
Jiayu Liu, Nannan Song, Yibing Huang, Yuxin Chen   +3 more
doaj   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Serum irisin levels and its association with blood glucose and insulin indices in diagnosing insulin resistance in adolescents with polycystic ovarian syndrome

Journal of Human Reproductive Sciences, 2021
Context: Irisin, a new myokine, has been found to be a biological marker of insulin resistance (IR). There is conflicting evidence on serum irisin level in adult women with polycystic ovarian syndrome (PCOS), and data are lacking in adolescents with PCOS.
Bhawina Sharan, Haritha Sagili, Sadish Kumar Kamalanathan, Subitha Lakshminarayanan   +3 more
doaj   +1 more source

Irisin – der neue Schlankmacher?

, 2013
Einleitung: Irisin ist ein Hormon, welches vom Muskel infolge von Aktivität ausschüttet wird. Beschrieben ist eine direkte Wirkung auf das Fettgewebe, da Irisin die Transdifferenzierung von weißem zu braunem Fettgewebe stimuliert. Aufgrund dieser Erkenntnis bestand die Frage, ob Irisin[for full text, please go to the a.m. URL]
Schäfer, B, Hemmrich, K, Paul, N, Fehsel, K, Pallua, N   +4 more
openaire   +2 more sources

An ultra‐processed food‐based cafeteria diet induces obesity, metabolic dysfunction, and tissue‐specific gene dysregulation in C57BL/6 mice

Animal Models and Experimental Medicine, EarlyView.
This schematic figure illustrates the experimental design and key findings of the study. Forty male C57BL/6 mice were assigned to either a standard diet control group or a cafeteria diet (CAFD) group for 16 weeks. CAFD induces obesity, insulin resistance (HOMA‐IR), hepatic steatosis, and dysregulation of a number of genes in visceral and subcutaneous ...
Guilherme Coutinho Kullmann Duarte, Daisy Crispim, Shiva Cerutti Wittée, Joana Raquel Nunes Lemos, Natalia Emerim Lemos, Mayara Souza de Oliveira, Melissa Daniele Alves, Eloísa Toscan Massignam, Tais Silveira Assmann, Felipe Mateus Pellenz   +9 more
wiley   +1 more source