Results 31 to 40 of about 19,243 (300)

Irisin, Two Years Later [PDF]

International Journal of Endocrinology, 2013
In January 2012, Boström and colleagues identified a new muscle tissue secreted peptide, which they named irisin, to highlight its role as a messenger that comes from skeletal muscle to other parts of the body. Irisin is a cleaved and secreted fragment of FNDC5 (also known as FRCP2 and PeP), a member of fibronectin type III repeat containing gene ...
Marta G. Novelle, Cristina Contreras, Amparo Romero-Picó, Miguel López, Carlos Diéguez   +4 more
openaire   +7 more sources

Irisin and Autophagy: First Update [PDF]

International Journal of Molecular Sciences, 2020
Aging and sedentary life style are considered independent risk factors for many disorders. Under these conditions, accumulation of dysfunctional and damaged cellular proteins and organelles occurs, resulting in a cellular degeneration and cell death. Autophagy is a conserved recycling pathway responsible for the degradation, then turnover of cellular ...
Pesce M., Ballerini P., Paolucci T., Puca I., Farzaei M. H., Patruno A.   +5 more
openaire   +2 more sources

Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities

Frontiers in Endocrinology, 2023
Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle is not beneficial to health. Exercise can promote many enabling pathways, particularly through circulating exerkines, to optimize individual health and quality of
C. S. Trettel, B. R. A. Pelozin, M. P. Barros, A. Bachi, P. G. S. Braga, C. M. Momesso, G. Furtado, P. Valente, E. Oliveira, E. Hogervorst, T. Fernandes   +10 more
semanticscholar   +1 more source

Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin αVβ5/AMPK signaling pathway after intracerebral hemorrhage in mice

Journal of Neuroinflammation, 2022
Background Neuroinflammation is a crucial factor in the development of secondary brain injury after intracerebral hemorrhage (ICH). Irisin is a newly identified myokine that confers strong neuroprotective effects in experimental ischemic stroke. However,
Yao Wang, Mi Tian, Jia-ying Tan, Xu Pei, Chaocheng Lu, Yuewen Xin, Shuixiang Deng, F. Zhao, Yanqin Gao, Ye Gong   +9 more
semanticscholar   +1 more source

Post-treatment With Irisin Attenuates Acute Kidney Injury in Sepsis Mice Through Anti-Ferroptosis via the SIRT1/Nrf2 Pathway

Frontiers in Pharmacology, 2022
Kidney is one of the most vulnerable organs in sepsis, resulting in sepsis-associated acute kidney injury (SA-AKI), which brings about not only morbidity but also mortality of sepsis.
Qiongyue Zhang, Y. Xin, P. Meng, M. Sulin, Yanlin Wang, Li Xinyi, Xuemin Song   +6 more
semanticscholar   +1 more source

Exploring the role of esketamine in alleviating depressive symptoms in mice via the PGC-1α/irisin/ERK1/2 signaling pathway

Scientific Reports, 2023
Esketamine provides an immediate and noticeable antidepressant effect, although the underlying molecular processes are yet unclear. Irisin induced by aerobic exercise has been implicated in the alleviation of depressive symptoms, whether irisin ...
Na Hu, Xuemei Chen, Chengchuan Chen, Xing Liu, Peng Yi, Tianhao Xu, Jing Jia, Jianguo Feng, Chunxiang Zhang, Xiaobin Wang   +9 more
doaj   +1 more source

Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1α-TXNIP/ROS-NLRP3 pathway in PCOS

Journal of Ovarian Research, 2023
Background Excessive production of androgen drives oxidative stress (OS) and inflammasome activation in ovarian granulosa cells (GCs). Therefore, the induced follicular developmental disorder is the major cause of infertility in women with polycystic ...
Yajing Weng, Yaling Zhang, Daojuan Wang, Rong Wang, Zou Xiang, S. Shen, Hongwei Wang, Xiaoke Wu, Y. Wen, Yong Wang   +9 more
semanticscholar   +1 more source

Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease

Cell Death and Disease, 2022
Irisin protects the cardiovascular system against vascular diseases. However, its role in chronic kidney disease (CKD) -associated vascular calcification (VC) and the underlying mechanisms remain unclear.
Qiu-hua Pang, Peiwen Wang, Yajing Pan, Xingtong Dong, Ting Zhou, Xinyu Song, A. Zhang   +6 more
semanticscholar   +1 more source

Irisin evokes bradycardia by activating cardiac-projecting neurons of nucleus ambiguus. [PDF]

, 2015
Irisin is a newly identified hormone induced in muscle and adipose tissues by physical activity. This protein and its encoding gene have been identified in the brain; in addition, the precursor for irisin, FNDC5, can cross the blood-brain barrier.
Brailoiu, Eugen, Brailoiu, Gabriela Cristina, Deliu, Elena, Sporici, Romeo A   +3 more
core   +2 more sources

Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects. [PDF]

PLoS ONE, 2015
A physically active life-style plays an independent role in the protection against type 2 diabetes and cardiovascular diseases. Irisin, a novel exercise-induced myokine, activates thermogenesis in rodents through increasing beige fat cells abundance ...
María Moreno, José María Moreno-Navarrete, Marta Serrano, Francisco Ortega, Elías Delgado, Cecilia Sanchez-Ragnarsson, Sergio Valdés, Patricia Botas, Wifredo Ricart, José Manuel Fernández-Real   +9 more
doaj   +1 more source