Results 41 to 50 of about 19,243 (300)
Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle [PDF]
, 2017 The estimates of global incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major
Chiesa, Claudio +4 more
core +2 more sources
Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages
International Journal of Molecular Medicine, 2023 Irisin is a hormone-like myokine that regulates cell signaling pathways and exerts anti-inflammatory effects. However, the specific molecular mechanisms involved in this process are currently unknown.
Zhuoxiao Han +5 more
semanticscholar +1 more source
Irisin, Exercise, and COVID-19
Frontiers in Endocrinology, 2022 Muscle and adipose tissue produce irisin during exercise. Irisin is thermogenic adipomyokine, improves glucose and lipid metabolism, and ameliorates the effects of obesity-driven inflammation, metabolic syndrome, and diabetes. In addition, exercise-induced irisin activates anti-inflammatory pathways and may play an essential role in improving the ...
Hugo Rodrigues Alves +5 more
openaire +3 more sources
Advanced Biomedical Research, 2021 Background: Osteoporosis is a prevalent elderly complication that is characterized by decreased bone mineral density and increased fracture risk because of dysregulation in bone mineralization and resorption.
Shirin Shahabi +5 more
doaj +1 more source
Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. [PDF]
, 2012 The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators
Seldin, Marcus M, Wong, G William
core +1 more source
Irisin and Secondary Osteoporosis in Humans [PDF]
International Journal of Molecular Sciences, 2022 Irisin is a peptide secreted by skeletal muscle following exercise that plays an important role in bone metabolism. Numerous experiments in vitro and in mouse models have shown that the administration of recombinant irisin promotes osteogenesis, protects osteocytes from dexamethasone-induced apoptosis, prevents disuse-induced loss of bone and muscle ...
Roberta Zerlotin +8 more
openaire +3 more sources
Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing
International Journal of Molecular Sciences, 2023 Bone fractures are a widespread clinical event due to accidental falls and trauma or bone fragility; they also occur in association with various diseases and are common with aging.
A. Oranger +10 more
semanticscholar +1 more source
Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer [PDF]
, 2019 Background. Fibronectin type III domain-containing (FNDC) proteins fulfill manifold functions in tissue development and regulation of cellular metabolism.
Adler, Andreas +12 more
core +2 more sources
Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression
eNeuro, 2023 Major depressive disorder (MDD) is a major cause of disability in adults. MDD is both a comorbidity and a risk factor for Alzheimer’s disease (AD), and regular physical exercise has been associated with reduced incidence and severity of MDD and AD ...
R. Lima-Filho +9 more
semanticscholar +1 more source
Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis
Frontiers in Pharmacology, 2019 ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treated ...
Hong Li +24 more
doaj +1 more source