Results 41 to 50 of about 5,686 (117)
How Pragmatic Are Sarcopenia Intervention Studies? A Systematic Review
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Sarcopenia is an age‐related muscle disease often accompanied by comorbidities, mobility issues and cognitive decline, which can limit treatment adherence in older adults. Owing to the reversible nature of sarcopenia, there has been a growing number of randomized controlled trials conducted in recent years.
Sophie Van Heden +4 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Sarcopenia is a progressive, age‐related condition characterized by a decline in skeletal muscle mass, strength and performance. Diagnosis remains challenging because current consensus criteria are difficult to scale and existing biomarkers lack accuracy.
Dongqin Xu +10 more
wiley +1 more source
Irisin: A myokine with locomotor activity [PDF]
Neuroscience Letters, 2015 The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats.
Weizhen Zhang +8 more
openaire +2 more sources
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Sarcopenia, an important complication of chronic obstructive pulmonary disease (COPD), is significantly associated with increased mortality. Systemic inflammation is an important trigger of COPD‐related skeletal muscle dysfunction. Calprotectin is a damage‐associated molecular pattern involved in the inflammatory response, but its ...
Liwei Liao +9 more
wiley +1 more source
Annexin A2 Causes Motor Incoordination via Muscle–Cerebellum Axis in Sarcopenia
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Sarcopenia is a prevalent age‐related disorder characterized by progressive muscle atrophy. Impaired balance is one of its most critical clinical consequences, often leading to falling and even bone fractures. As the cerebellum plays a central role in regulating motor coordination, elucidating the molecular mechanisms underlying ...
Xin Jiao +16 more
wiley +1 more source
Age‐Stratified Associations of Sarcopenic Obesity With Mortality in Type 2 Diabetes
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Sarcopenic obesity, the coexistence of sarcopenia and obesity, has been linked to adverse health outcomes due to comorbidity. Evidence on the association between sarcopenic obesity and mortality among individuals with Type 2 diabetes remains limited Methods Sarcopenic obesity was defined using Japan Working Group on Sarcopenic ...
Shinta Yamamoto +16 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION Muscular function is essential for healthy aging. This study examined the relationship between baseline muscle condition and changes in cognitive performance over 2 years. METHODS We conducted an observational analysis of longitudinal data from the control arm of the Finnish Geriatric Intervention Study to Prevent Cognitive ...
Miguel German Borda +12 more
wiley +1 more source
Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review
Medicine Bulletin, Volume 2, Issue 1, Page 94-123, January 2026.ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng +8 more
wiley +1 more source
Is Irisin Anticancer Agent? [PDF]
The 2nd International Cell Death Research Congress, 2018 Irisin is a protein, which is encoded by the FNDC5 gene. Irisin secreted as a hormone secret via Fibronectin type III domain-containing protein 5. Irisin is always provide beneficial effect of exercise on cellular metabolism as well as obesity and metabolic diseases. In addition, it plays a role in cancer.
openaire +2 more sources
Irisin Prevents Disuse-Induced Osteocyte Apoptosis
Journal of Bone and Mineral Research, 2019 ABSTRACT Previous results showed that intermittently administered irisin improves bone mass in normal mice and prevents the development of disuse-induced osteoporosis and muscular atrophy in hindlimb-suspended mice, a murine model able to mimic the absence of mechanical loading.
Giuseppina Storlino +8 more
openaire +3 more sources