Results 41 to 50 of about 6,991 (174)

Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn. [PDF]

PLoS ONE, 2016
Irisin is considered to be a myokine and adipokine that may also participate in reproductive functions, as it increases significantly throughout pregnancy.
Maria Hernandez-Trejo, Gerardo Garcia-Rivas, Alejandro Torres-Quintanilla, Estibalitz Laresgoiti-Servitje   +3 more
doaj   +1 more source

Disordered metabolism in mice lacking irisin [PDF]

Scientific Reports, 2020
AbstractIrisin is a product of fibronectin type III domain-containing protein (Fndc5) and is involved in the regulation of adipokine secretion and the differentiation of osteoblasts and osteoclasts. In this study, we aimed to determine whether irisin lacking affects glucose/lipid and bone metabolism.
Luo, Yunyao, Qiao, Xiaoyong, Ma, Yaxian, Deng, Hongxia, Xu, Charles C., Xu, Liangzhi   +5 more
openaire   +2 more sources

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Irisin reduces senile osteoporosis by inducing osteocyte mitophagy through Ampk activation

iScience
Summary: Irisin, an exercise-induced myokine, is known to be able to regulate bone metabolism. However, the underlying mechanisms regarding the effects of irisin on senile osteoporosis have not been fully elucidated. Here, we demonstrated that irisin can
Honghan Li, Deqing Luo, Wei Xie, Wenbin Ye, Jinlong Chen, Paolo Alberton, Mingzhu Zhang, Eryou Feng, Denitsa Docheva, Dasheng Lin   +9 more
doaj   +1 more source

Irisin is more strongly associated with leisure-time physical activity than resistin and high-density lipoprotein cholesterol are

Journal of Exercise Science & Fitness, 2022
Background/Objectives: Irisin is a myokine with a potential role in cardiometabolic diseases, but previous studies have described inconsistencies between serum irisin and physical activity (PA).
María del Cristo Rodríguez-Pérez, Titta Katariina Kontro, Delia Almeida González, Beatriz Gómez Álvarez, Itahisa Marcelino Rodríguez, y Antonio Cabrera de León   +5 more
doaj   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

Redox Biology, 2019
Current management of liver ischemia-reperfusion (I/R) injury is mainly based on supportive care and no specific treatment is available. Irisin, a recently identified hormone, plays pivotal roles in energy expenditure and oxidative metabolism; however ...
Jianbin Bi, Jia Zhang, Yifan Ren, Zhaoqing Du, Qingshan Li, Yue Wang, Shasha Wei, Lifei Yang, Jingyao Zhang, Chang Liu, Yi Lv, Rongqian Wu   +11 more
doaj   +1 more source

Determination of Irisin, Body Mass Index, and Other Biochemical Parameters in a Sample of Iraqi Type II Diabetic Patients

Journal of Techniques, 2022
Evidence suggests that Irisin, a peptide hormone, may play a role in lipid metabolism, insulin resistance, and obesity. On the other hand, its role in type 2 diabetic Mellitus [T2DM] in humans is uncertain.
Takwa Al Koloob Ali Chachan, Huda Farhan, Shatha Hamed   +2 more
doaj   +1 more source

Biodegradable Natural Polymer‐Based Drug Delivery Systems for Bone Tissue Engineering

Medicinal Research Reviews, EarlyView.
ABSTRACT The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune rejection, mechanical failure, and delayed healing.
Hyejin Jo, Shinwon Kang, Jae Eun Yang, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

İrisin ve Vasküler Kontraktilite Üzerine Etkileri

SDÜ Tıp Fakültesi Dergisi, 2021
Bu derleme, irisin hakkındaki mevcut bilgileri ve irisinin vasküler tonusa aracılık etmedeki etkin rolünü özetleme çabasıdır. Egzersiz kronik, bulaşıcı olmayan hastalıkların, tip 2 diyabetin ve özellikle kardiyovasküler hastalıkların önlenmesinde bir dayanak noktasıdır.
DEMİREL, Sadettin, TIP FAKÜLTESİ, ŞAHİNTÜRK, Serdar, ÖZYENER, Fadıl   +3 more
openaire   +6 more sources