Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review [PDF]
, 2017 Background: Exercise may activate a brown adipose-like phenotype in white adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator ...
Dinas, Petros C. +6 more
core +2 more sources
Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling
Frontiers in Physiology, 2019 Irisin is an exercise-induced myokine known to induce adipocyte browning through induction of uncoupling protein 1. Recent studies have reported that irisin is also an adipokine.
Eun Bi Ma +3 more
doaj +1 more source
Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts. [PDF]
PLoS ONE, 2015 Exercise offers short-term and long-term health benefits, including an increased metabolic rate and energy expenditure in myocardium. The newly-discovered exercise-induced myokine, irisin, stimulates conversion of white into brown adipocytes as well as ...
Chao Xie +14 more
doaj +1 more source
Clinical and Translational Medicine, 2020 Background Sepsis remains a major health issue without an effective therapy. Ferroptosis, an iron‐dependent programmed cell death, has been proposed to be related to the pathogenesis of sepsis.
Shasha Wei +9 more
doaj +1 more source
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Nature Network Boston, 2018 Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin ...
Mychael V. Lourenco +24 more
semanticscholar +1 more source
Vitamin D Increases Irisin Serum Levels and the Expression of Its Precursor in Skeletal Muscle
International Journal of Molecular Sciences, 2023 Irisin is a myokine synthesized by skeletal muscle, which performs key actions on whole-body metabolism. Previous studies have hypothesized a relationship between irisin and vitamin D, but the pathway has not been thoroughly investigated.
L. Sanesi +11 more
semanticscholar +1 more source
FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle [PDF]
, 2016 [Abstract] Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function.
Cordido, Fernando +5 more
core +2 more sources
Journal of Translational Medicine, 2023 Background Exercise-related signaling Fndc5/irisin expresses in brain and acts as a crucial regulator of cognitive function, but its detailed roles in vascular dementia (VaD) are still unclear.
Degang Song +10 more
semanticscholar +1 more source
The Association of Irisin with the Progression of Diabetes Mellitus Irisin and Diabetes Progression [PDF]
Advances in Diabetes and Metabolism, 2018 Introduction: There is an ongoing debate over the involvement of irisin in the glucose metabolism. In this study, we aimed to see the association of irisin with the markers of glucose intolerance. Materials and Methods: We analyzed the relation of irisin with metabolic markers such as Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), insulin ...
Özlem Çakır Madenci +5 more
openaire +2 more sources
Irisin, Energy Homeostasis and Male Reproduction [PDF]
Frontiers in Physiology, 2021 Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain-containing protein 5 (FNDC5). It is involved in the browning of white adipose tissue, glucose tolerance, and reversing of metabolic disruptions.
Pallav Sengupta +5 more
openaire +4 more sources