Results 61 to 70 of about 6,991 (174)

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source

The skeletal muscle–adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management

Experimental Physiology, EarlyView.
Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su, Na Liu, Yang Liu, Yiqun Sun, Yike Jiao   +4 more
wiley   +1 more source

Irisin-loaded Porous Silica Nanoparticles Enhance Bone Healing in High Cholesterol Diet-induced Medaka Fish Model

Precision Nanomedicine
Irisin is a myokine that stimulates browning of white adipocytes and enhances cortical bone mass during physical exercise. However, its short half-life limits its therapeutic potential, making sustained delivery systems desirable for bone tissue ...
Prashant Sadanandan, Silja Krishnan, Manzoor Koyakutty, Manitha Nair   +3 more
doaj   +1 more source

Circulating Irisin Is Reduced in Male Patients with Type 1 and Type 2 Myotonic Dystrophies

Frontiers in Endocrinology, 2017
ContextMyotonic dystrophies (DM) are dominantly inherited muscle disorders characterized by myotonia, muscle weakness, and wasting. The reasons for sarcopenia in DMs are uncleared and multiple factors are involved. Irisin, a positive hormone regulator of
Elena Dozio, Elena Passeri, Rosanna Cardani, Stefano Benedini, Carmen Aresta, Rea Valaperta, Massimiliano Corsi Romanelli, Massimiliano Corsi Romanelli, Giovanni Meola, Giovanni Meola, Valeria Sansone, Valeria Sansone, Sabrina Corbetta, Sabrina Corbetta   +13 more
doaj   +1 more source

Is Irisin an Anticarcinogenic Peptide?

Medicine Science | International Medical Journal, 2015
Prostate cancer is the most common type of cancer in males. There has been currently no therapy to cure various types of cancer, and hence, studies aiming to develop cancer treatment are important and have been ongoing. Irisin is a hormone, which regulates body weight and metabolism, including insulin resistance and is thought to have beneficial ...
Suat, Tekin, Yavuz, Erden, Suleyman, Sandal, Bayram, Yilmaz   +3 more
openaire   +3 more sources

Seven days of warm‐water immersion enhances resting irisin and BDNF, but not klotho, in older men

Experimental Physiology, EarlyView.
Abstract We examined whether seven consecutive days of warm‐water immersion could elevate resting and exercise‐induced levels of brain‐derived neurotrophic factor (BDNF), irisin and klotho in older adults. These biomarkers support cognitive and metabolic health, but their levels decline with age.
Joel M Garrett, James J McCormick, Kelli E King, Kristina‐Marie T Janetos, Nathalie V Kirby, Fergus K O'Connor, Glen P Kenny   +6 more
wiley   +1 more source

The association of circulating irisin with metabolic risk factors in Chinese adults: a cross-sectional community-based study

BMC Endocrine Disorders, 2019
Background Irisin is a myokine that leads to increased energy expenditure by stimulating the browning of white adipose tissue. We aimed to investigate the association of serum irisin levels with metabolic parameters in middle aged Chinese population ...
Lizhi Tang, Yuzhen Tong, Fang Zhang, Guilin Chen, Yun Cong Zhang, John Jobin, Nanwei Tong   +6 more
doaj   +1 more source

Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Sarcopenia is an age‐related condition characterized by progressive muscle mass, strength and physical performance declines, contributing to frailty and adverse health outcomes. Despite increasing interest in molecular biomarkers, longitudinal data with external validation are limited.
Sung Hye Kong, Ok Hee Jeon, Ji Yeon Kim, Miji Kim, Jinhee Kim, Seung Shin Park, Hak Chul Chang, Chang Won Won, Dohyun Han   +8 more
wiley   +1 more source

Irisin: A myokine with locomotor activity [PDF]

Neuroscience Letters, 2015
The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats.
Weizhen Zhang, Lin Chang, Chao Zhang, Ruthann Zhang, Ziru Li, Biaoxin Chai, Jiyao Li, Eugene Chen, Michael Mulholland   +8 more
openaire   +2 more sources

Muscle Weakness and the Irisin–BDNF and Oxidative Stress Axis in the 60‐Day Pseudorandomised Controlled AGBRESA Bed Rest Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Muscle atrophy and weakness are among the most detrimental consequences of disuse, microgravity, hospitalisation and ageing. Oxidative modifications of myofibrillar proteins generated by oxidative stress may contribute to the reduced force‐ and power‐generating capacity of skeletal muscles. As part of the 60‐day AGBRESA bed rest (BR)
Alessandra Bosutti, Bergita Ganse, Edwin Mulder, Markus Gruber, Maria Venegas‐Carro, Jochen Zange, Jörn Rittweger, Moritz Eggelbusch, Rob C. I. Wüst, Paul Hendrickse, Hans Degens   +10 more
wiley   +1 more source