Results 71 to 80 of about 6,991 (174)

IL‐15 Links Muscle–Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Objectives High glucose induces mitochondrial dysfunction in podocytes, contributing to the development of diabetic nephropathy (DN). There is increasing evidence that muscles play a protective role by secreting myokines into the kidneys. Here, we investigated how skeletal muscle influences podocyte health via muscle–kidney crosstalk.
Yin Li, Jialing Rao, Weiyan Lai, Yuxiang Sun, Hongchun Lin, Jun Zhang, Zengchun Ye, Zhaoyong Hu, Hui Peng   +8 more
wiley   +1 more source

Study on changes in serum irisin level in free-flap transplantation and the correlation of serum irisin level with flap blood flow

Heliyon
Background and aims: The beneficial effect of myokine irisin on ischemia-reperfusion of skin flaps has been rarely reported in clinical studies. This study was designed to determine whether irisin plays a protective role in flap transplantation and ...
Xianyao Tao, Xiaoyun Pan, Gang Zhao, Yongjun Rui   +3 more
doaj   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Resistance training and subcortical vascular cognitive impairment: A 12‐month randomized trial

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION It is unknown whether progressive resistance training (PRT) improves cognitive function in adults with cerebral small vessel disease and mild cognitive impairment (i.e., subcortical vascular cognitive impairment [SVCI]). METHODS We conducted a 12‐month randomized trial comparing PRT versus balance and tone exercises (BAT) on the ...
Teresa Liu‐Ambrose, Ryan S. Falck, Elizabeth Dao, Rachel A. Crockett, Cindy K. Barha, Narlon C. Boa Sorte Silva, Walid A. Alkeridy, John R. Best, Ging‐Yuek R. Hsiung, Thalia S. Field, Kenneth M. Madden, Jennifer C. Davis, Lisanne F. ten Brinke, Roger C. Tam   +13 more
wiley   +1 more source

Fat Mass Influences Femur Bone Strength and Geometry Parameters, but Not Bone Mineral Density, in Autoimmune Diabetes: A Pilot Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 3, March 2026.
ABSTRACT Background Autoimmune diabetes (AD) increases fracture risk. Overweight worsens bone health despite increasing bone mineral density (BMD). This study examines how adiposity influences BMD and Dual X‐Ray Absorptiometry (DXA)‐derived parameters of bone geometry and strength in AD.
Renata Risi, Rocco Amendolara, Vahideh Abedi, Francesco De Vita, Federica Barbaro, Angela Balena, Mikiko Watanabe, Daniela Luverà, Angelo Lauria Pantano, Luca D'Onofrio, Raffaella Buzzetti, Ernesto Maddaloni, On behalf ofAD_OWOB study group   +12 more
wiley   +1 more source

Dietary Bioactives and Physical Activity in the Regulation of Hippocampal Neurogenesis and Cognitive Decline

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Exercise and dietary polyphenols enhance hippocampal plasticity and cognitive function via complementary molecular mechanisms. Central pathways include BDNF signaling, inflammation control, and mitochondrial regulation. Although synergy is mainly supported by preclinical data, lifestyle‐based strategies show promise for brain health maintenance ...
Zhenyi Zhao, Sima‐sadat Sabihi
wiley   +1 more source

Is Irisin Anticancer Agent? [PDF]

The 2nd International Cell Death Research Congress, 2018
Irisin is a protein, which is encoded by the FNDC5 gene. Irisin secreted as a hormone secret via Fibronectin type III domain-containing protein 5. Irisin is always provide beneficial effect of exercise on cellular metabolism as well as obesity and metabolic diseases. In addition, it plays a role in cancer.
openaire   +2 more sources

Cerebral in situ ischemic postconditioning: From bench to bedside and beyond

Neuroprotection, Volume 4, Issue 1, Page 48-64, March 2026.
This review explores the translational potential of in situ ischemic postconditioning in acute ischemic stroke. Preclinical and clinical evidence is summarized to highlight its promise as a neuroprotective strategy in the era of endovascular therapy.
Xiao Jiang, Wenbo Zhao, Yongbo Xu, Fanlei Meng, Ming Wei   +4 more
wiley   +1 more source

Impact of combined ginsenoside‐MC1 and irisin on mitochondrial apoptosis in diabetic rats with hepatic reperfusion injury: Role of AMPK/JNK signalling

Experimental Physiology, Volume 111, Issue 3, Page 751-764, 1 March 2026.
Abstract Hepatic ischaemia–reperfusion (IR) injury is a serious clinical issue, especially in patients with type 2 diabetes mellitus (T2DM). As mitochondria play a critical role in the regulation of IR‐induced liver damage, mitochondria‐targeted treatment is of the utmost significance for improving outcomes.
Jie Lin, Lei Han, Zhigang Ma, Bo Yuan, Yabin Yu   +4 more
wiley   +1 more source

Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetes

International Journal of Endocrinology, 2014
Objectives. Sclerostin, an osteocyte-specific protein, has been found to be related to adiposity and glucose metabolism. Irisin, a myokine, can affect browning of white fat and influence glucose and energy homeostasis.
Theerawut Klangjareonchai, Hataikarn Nimitphong, Sunee Saetung, Nuttapimon Bhirommuang, Rattanapan Samittarucksa, Suwannee Chanprasertyothin, Rattana Sudatip, Boonsong Ongphiphadhanakul   +7 more
doaj   +1 more source