Results 1 to 10 of about 83,013 (204)
Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1. [PDF]
PLoS ONE, 2012 BackgroundMembers of the WhiB-like (Wbl) protein family possess iron-sulfur clusters and are implicated in the regulation of developmental processes in Actinomycetes. Mycobacterium tuberculosis possesses seven Wbl proteins.
Laura J Smith +3 more
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Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway [PDF]
Communications Biology, 2023 Iron-sulfur clusters are essential for life and defects in their biosynthesis lead to human diseases. The mechanism of cluster assembly and delivery to cytosolic and nuclear client proteins via the cytosolic iron-sulfur cluster assembly (CIA) pathway is ...
Sheena Vasquez +7 more
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Structure of a Wbl protein and implications for NO sensing by M. tuberculosis [PDF]
Nature Communications, 2017 Mycobacterium tuberculosis WhiB1 is a DNA-binding protein with a NO sensitive [4Fe-4S] cluster. Here the authors present the NMR structure of WhiB1 and suggest how loss of the iron-sulfur cluster through nitrosylation affects WhiB1 DNA binding and leads ...
Bassam K. Kudhair +9 more
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The iron-sulfur cluster is essential for DNA binding by human DNA polymerase ε [PDF]
Scientific Reports, 2022 DNA polymerase ε (Polε) is a key enzyme for DNA replication in eukaryotes. Recently it was shown that the catalytic domain of yeast Polε (PolεCD) contains a [4Fe-4S] cluster located at the base of the processivity domain (P-domain) and coordinated by ...
Alisa E. Lisova +5 more
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Modulation of MagR magnetic properties via iron–sulfur cluster binding
Scientific Reports, 2021 Iron–sulfur clusters are essential cofactors found in all kingdoms of life and play essential roles in fundamental processes, including but not limited to respiration, photosynthesis, and nitrogen fixation.
Zhen Guo +11 more
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Microbiology Spectrum, 2023 Iron-sulfur [Fe-S] clusters are one of the most ancient and functionally versatile natural biosynthetic prosthetic groups required by various proteins involved in important metabolic processes, including the oxidative phosphorylation of proteins ...
Xingju Song +5 more
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iScience, 2021 Summary: Mitochondria are a hallmark of eukaryal cells and play an important role in cellular metabolism. There is a vast amount of knowledge available on mitochondrial metabolism and essential mitochondrial functions, such as protein import and iron ...
Carl Malina +3 more
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Communications Chemistry, 2023 Iron-sulfur clusters are prosthetic groups of proteins involved in various biological processes. However, details of the immature state of the iron-sulfur cluster into proteins have not yet been elucidated. We report here the first structural analysis of
Erika Tsutsumi +9 more
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Crystallographic characterization of the high-potential iron-sulfur protein in the oxidized state at 0.8 Å resolution. [PDF]
PLoS ONE, 2017 High-potential iron-sulfur protein (HiPIP) is a soluble electron carrier protein of photosynthetic bacteria with an Fe4S4 cluster. Although structural changes accompanying the electron transfer are important for understanding of the functional mechanism,
Hiraku Ohno +6 more
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Sulfur Administration in Fe–S Cluster Homeostasis
Antioxidants, 2021 Mitochondria are the key organelles of Fe–S cluster synthesis. They contain the enzyme cysteine desulfurase, a scaffold protein, iron and electron donors, and specific chaperons all required for the formation of Fe–S clusters.
Leszek Rydz +2 more
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