Results 21 to 30 of about 83,013 (204)
Down the Iron Path: Mitochondrial Iron Homeostasis and Beyond
Cells, 2021 Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent. Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate these cofactors along with iron ions into mitochondrial proteins that support ...
Jonathan V. Dietz +2 more
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Crystallographic snapshots of sulfur insertion by lipoyl synthase [PDF]
, 2018 Lipoyl synthase (LipA) catalyzes the insertion of two sulfur atoms at the unactivated C6 and C8 positions of a protein-bound octanoyl chain to produce the lipoyl cofactor. To activate its substrate for sulfur insertion, LipA uses a [4Fe-4S] cluster and S-
Booker, Squire J. +5 more
core +1 more source
Cluster and fold stability of E. coli ISC-type ferredoxin.
PLoS ONE, 2013 Iron-sulfur clusters are essential protein prosthetic groups that provide their redox potential to several different metabolic pathways. Formation of iron-sulfur clusters is assisted by a specialised machine that comprises, among other proteins, a ...
Robert Yan +6 more
doaj +1 more source
Clinical and genetic aspects of defects in the mitochondrial iron-sulfur cluster synthesis pathway [PDF]
, 2018 Iron-sulfur clusters are evolutionarily conserved biological structures which play an important role as cofactor for multiple enzymes in eukaryotic cells.
Van Coster, Rudy, Vanlander, Arnaud
core +2 more sources
Mechanism of Iron–Sulfur Cluster Assembly: In the Intimacy of Iron and Sulfur Encounter
Inorganics, 2020 Iron–sulfur (Fe–S) clusters are protein cofactors of a multitude of enzymes performing essential biological functions. Specialized multi-protein machineries present in all types of organisms support their biosynthesis.
Batoul Srour +3 more
doaj +1 more source
Redox-Sensing Iron–Sulfur Cluster Regulators [PDF]
, 2018 Significance: Iron–sulfur cluster proteins carry out multiple functions, including as regulators of gene transcription/translation in response to environmental stimuli.
Crack, Jason C, Le Brun, Nick E
core +1 more source
Structural Basis of RICs Iron Donation for Iron-Sulfur Cluster Biogenesis
Frontiers in Microbiology, 2021 Escherichia coli YtfE is a di-iron protein of the widespread Repair of Iron Centers proteins (RIC) family that has the capacity to donate iron, which is a crucial component of the biogenesis of the ubiquitous family of iron-sulfur proteins.
Liliana S. O. Silva +4 more
doaj +1 more source
TtcA a new tRNA-thioltransferase with an Fe-S cluster [PDF]
, 2014 International audienceTtcA catalyzes the post-transcriptional thiolation of cytosine 32 in some tRNAs. The enzyme from Es-cherichia coli was homologously overexpressed in E. coli.
Atta, Mohamed +6 more
core +4 more sources
Biomolecules, 2021 Maintaining iron homeostasis is fundamental for almost all living beings, and its deregulation correlates with severe and debilitating pathologies.
Cécilia Hognon +5 more
doaj +1 more source
Insights from 125Te and 57Fe nuclear resonance vibrational spectroscopy: a [4Fe-4Te] cluster from two points of view. [PDF]
, 2019 Iron-sulfur clusters are common building blocks for electron transport and active sites of metalloproteins. Their comprehensive investigation is crucial for understanding these enzymes, which play important roles in modern biomimetic catalysis and ...
Apfel, Ulf-Peter +8 more
core +2 more sources