Results 21 to 30 of about 3,189,219 (271)

Iron chelation therapy [PDF]

Journal of Internal Medicine, 1997
Desferrioxamine (DFX) remains the most effective and safe iron chelator for treatment of patients with transfusional iron overload. It is usually given by intermittent subcutaneous infusions for 8–12 h on 4–6 days weekly using a battery‐driven pump. Disposable balloon infusers provide a suitable method of giving continuous subcutaneous infusions with ...
A V, Hoffbrand, B, Wonke
openaire   +2 more sources

A Speciation Study on the Perturbing Effects of Iron Chelators on the Homeostasis of Essential Metal Ions. [PDF]

PLoS ONE, 2015
A number of reports have appeared in literature calling attention to the depletion of essential metal ions during chelation therapy on β-thalassaemia patients.
Guido Crisponi, Valeria Marina Nurchi, Miriam Crespo-Alonso, Gavino Sanna, Maria Antonietta Zoroddu, Giancarla Alberti, Raffaela Biesuz   +6 more
doaj   +1 more source

Use of deferoxamine (DFO) in transfusion-dependent β-thalassemia during pregnancy: A retrospective study

Taiwanese Journal of Obstetrics & Gynecology, 2020
Objective: To report cases of use of chelation therapy during pregnancy which resulted in favorable outcomes for the babies. Materials and methods: In this retrospective cohort study, we described the evolution and outcome of 9 pregnancies in Italian ...
Maria Grazia Piccioni, Carmela Capone, Flaminia Vena, Valentina Del Negro, Michele Carlo Schiavi, Valentina D'Ambrosio, Antonella Giancotti, Maria Paola Smacchia, Roberto Brunelli   +8 more
doaj   +1 more source

Predictors of Non-adherence to iron chelation therapy in pediatric thalassemia patients

Journal of Rawalpindi Medical College, 2022
Objective: This study was conducted to identify predictors of non-adherence to iron chelation therapy among children suffering from β-thalassemia major across different treatment regimens.
Muniba Kanwal, Rizwan Shafeeq Ahmad, Naima Tariq, Gul -e- Rehan   +3 more
doaj   +1 more source

Iron-Chelating Therapy for Transfusional Iron Overload [PDF]

New England Journal of Medicine, 2011
A 16-year-old boy with sickle cell anemia undergoes routine screening with transcranial Doppler ultrasonography to assess the risk of stroke. This examination shows an abnormally elevated blood-flow velocity in the middle cerebral artery. The hemoglobin level is 7.2 g per deciliter, the reticulocyte count is 12.5%, and the fetal hemoglobin level is 8.0%
TACCONE GALLUCCI, MASSIMO, MANCA DI VILLAHERMOSA, SIMONE, Noce, A.   +2 more
openaire   +7 more sources

Overview of chelation recommendations for thalassaemia and sickle cell disease

Thalassemia Reports, 2014
The long term consequences of iron toxicity are mostly reversible with effective iron chelation therapy. Recommendations for use of chelation therapy in transfusion dependent thalassaemia (TDT), sickle cell disease (SCD) and non transfusion dependent ...
Banu Kaya
doaj   +1 more source

How early can myocardial iron overload occur in Beta thalassemia major? [PDF]

, 2014
BACKGROUND: Myocardial siderosis is the most common cause of death in patients with beta thalassemia major(TM). This study aimed at investigating the occurrence, prevalence and severity of cardiac iron overload in a young Chinese population with beta TM.
Gaohui Yang, Pan Hongfei, He, T, Lai, Y, Peng, P, Liu Rongrong, Long, X, Taigang He, Tan Shaohong, Liu, R, Hongfei Pan, Yang Weijia, Xingjiang Long, Rongrong Liu, Lai Yongrong, Yang Gaohui, He Taigang, Weijia Yang, Yang, G, Xinhua Zhang, Tan, S, Liling Long, Anderson Lisa, Lisa Anderson, Long Xingjiang, Yang, W, Zhang, X, Anderson, L, Peng Peng, Yongrong Lai, Zhang Xinhua, Long Liling, Pan, H, Shaohong Tan, Long, L   +34 more
core   +2 more sources

Iron Chelation Therapy in COVID-19 Infection

Southeastern European Medical Journal, 2022
The recent outbreak of corona virus and coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus is a global concern. Despite efforts to clarify the physiology and potential therapy, specific guidelines for the treatment of COVID-19 disease have yet
Irena Krajina Kmoniček, Anja Tomić, Josip Kocur   +2 more
doaj   +1 more source

Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan [PDF]

, 2014
There is a need to standardise non-invasive measurements of liver iron concentrations (LIC) so clear inferences can be drawn about body iron levels that are associated with hepatic and extra-hepatic complications of iron overload.
Alam, MH, Mohammed H Alam, He, T, Taigang He, Pennell, DJ, Gillian Smith, Carpenter, JP, Garbowski, MW, Dudley J Pennell, Maciej W Garbowski, John-Paul Carpenter, Porter, JB, John B Porter, Smith, G, Michael Roughton, Roughton, M   +15 more
core   +1 more source

Healthcare resource utilization and direct costs of transfusion-dependent thalassemia patients in Dubai, United Arab Emirates: a retrospective cost-of-illness study

BMC Health Services Research, 2022
Background Patients with transfusion-dependent thalassemia (TDT) require lifelong blood transfusions and iron chelation therapy. Thus, patients afflicted with TDT often have to undergo blood transfusion and iron chelation therapy, which causes a major ...
Shaikha Alshamsi, Samer Hamidi, Hacer Ozgen Narci   +2 more
doaj   +1 more source