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An update on iron chelation therapy.

Blood transfusion = Trasfusione del sangue, 2012
Iron overload is a common clinical problem, arising from disorders of increased iron absorption such as hereditary haemochromatosis or thalassaemia intermedia syndromes or as a consequence of chronic blood transfusions for various blood disorders. Regular red blood cell (RBC) transfusions are the principal supportive therapy for many rare anaemias ...
E. Poggiali, E. Cassinerio, L. Zanaboni, M.D. Cappellini   +3 more
openaire   +2 more sources

Combination Therapies in Iron Chelation [PDF]

Thalassemia Reports, 2014
The availability of oral iron chelators and new non-invasive methods for early detection and treatment of iron overload, have significantly improved the life expectancy and quality of life of patients with β thalassemia major. However, monotherapy is not effective in all patients for a variety of reasons.
openaire   +2 more sources

Brazilian Thalassemia Association protocol for iron chelation therapy in patients under regular transfusion

Revista Brasileira de Hematologia e Hemoterapia, 2013
In the absence of an iron chelating agent, patients with beta-thalassemia on regular transfusions present complications of transfusion-related iron overload.
Monica Pinheiro de Almeida Verissimo, Sandra Regina Loggetto, Antonio Fabron Junior, Giorgio Roberto Baldanzi, Nelson Hamerschlak, Juliano Lara Fernandes, Aderson da Silva Araujo, Clarisse Lopes de Castro Lobo, Kleber Yotsumoto Fertrin, Vasilios Antonios Berdoukas, Renzo Galanello   +10 more
doaj   +1 more source

Objectives and Methods of Iron Chelation Therapy [PDF]

Bioinorganic Chemistry and Applications, 2003
Recent developments in the understanding of the molecular control of iron homeostasis provided novel insights into the mechanisms responsible for normal iron balance. However in chronic anemias associated with iron overload, such mechanisms are no longer sufficient to offer protection from iron toxicity, and iron chelating therapy is the only method ...
Hershko, C., Abrahamov, A., Konijn, A. M., Breuer, W., Cabantchik, I. Z., Pootrakul, P., Link, G.   +6 more
openaire   +2 more sources

Markers of Renal Complications in Beta Thalassemia Patients with Iron Overload Receiving Chelation Agent Therapy: A Systematic Review

, 2022
OBJECTIVE: The emerging renal complications in beta-thalassemia patients have raised the global exchange of views. Despite better survival due to blood transfusion and iron chelation therapy, the previously unrecognized renal complication remain a burden
Bintoro, Siprianus Ugroseno Yudho, Widiasi, Etha Dini, Prahasanti, Kartika, Ashariati, Ami, Adhikara, Imam Manggalya, Putra, Yasjudan Rastrama, Romadhon, Pradana Zaky, Thaha, Mochammad, Windradi, Choirina, Suryantoro, Satriyo Dwi, Agustin, Esthiningrum Dewi, Prabowo, Emil, Adyarini, Dwita Dyah, Thahadian, Harik Firman, Novendrianto, Dwiki, Yusoff, Narazah Mohd, Widiyastuti, Krisnina Nurul, Mahdi, Bagus Aulia, Martani, Okla Sekar, Putri, Aditea Etnawati   +19 more
core   +1 more source

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Assessment of iron chelation therapy adherence in patients with thalassemia major in Babylon Province

Journal of Applied Hematology, 2023
BACKGROUND: Thalassemia is severe public health problem in Iraq and other nearby countries, represents about 75% of all hemogloniopathy with prevalence and incidence 36/100.000 and 34/100.000 respectively.
Mohammed Ali Al-Jabory, Athmar Kadhim Gatea, Qusay Naser Hussein   +2 more
doaj   +1 more source

Polyphenol‐Inspired Materials for Agricultural Applications

Advanced Materials, EarlyView.
This review outlines the use of polyphenol‐inspired materials for sustainable agriculture, highlighting their molecular design, interfacial assembly, structure–property relationships, and prospects toward precision agriculture, climate resilience, ecosystem protection, and circular bioeconomy strategies.
Haofu Liu, Omid Mazaheri, Zhixing Lin, Tianzheng Wang, Jingqu Chen, Yuang Gu, Xia Liang, Deli Chen, Frank Caruso   +8 more
wiley   +1 more source

Erythrocytapheresis as a strategy to manage anemia and iron overload in nondeletional hemoglobin H disease

eJHaem
Hemoglobin H (HbH) disease is associated with anemia, ineffective erythropoiesis, and iron overload. We report a case of a patient with HbH/Hb Constant Spring disease, who was maintained on chronic transfusions as an adult due to symptomatic anemia. Over
Ke Zhang, John Bliamptis, Janice Park, Patricia Kopko, Amber P. Sanchez, Srila Gopal   +5 more
doaj   +1 more source

Timed non-transferrin bound iron determinations probe the origin of chelatable iron pools during deferiprone regimens and predict chelation response

Haematologica, 2012
Background Plasma non-transferrin bound iron refers to heterogeneous plasma iron species, not bound to transferrin, which appear in conditions of iron overload and ineffective erythropoiesis.
Yesim Aydinok, Patricia Evans, Chantal Y. Manz, John B. Porter   +3 more
doaj   +1 more source