Results 41 to 50 of about 3,189,219 (271)

A Critical Call for Mechanistic Investigations of Metal‐Bacteria Interactions

Advanced Materials, EarlyView.
It is well established that the antibacterial properties of metals have tremendous importance for bioengineering applications. What is not as appreciated, however, is the reproducibility crisis in this field's vast literature. In this perspective, we highlight this reproducibility problem, discuss its sources, and suggest solutions towards focused ...
J. Rackwitz, A. Bandyopadhyay, S. Belkin, S. Bose, N. Eliaz, J. L. Gilbert, T. C. Lowe, F. Mücklich, R. J. Turner, C. C. Tasan   +9 more
wiley   +1 more source

TRANSIENT ELASTOGRAPHY (TE) IS A USEFUL TOOL FOR ASSESSING THE RESPONSE OF LIVER IRON CHELATION IN SICKLE CELL DISEASE PATIENTS

Mediterranean Journal of Hematology and Infectious Diseases, 2018
Sickle cell disease patients often need regular blood transfusions to improve both the quality of life and survival from the veno-occlusive complications of the disease.
SOPHIA DELICOU
doaj   +1 more source

Iron-Chelating Therapy and the Treatment of Thalassemia [PDF]

Blood, 1997
Iron-chelating therapy with deferoxamine in patients with thalassemia major has dramatically altered the prognosis of this previously fatal disease. The successes achieved with deferoxamine, as well as the limitations of this treatment, have stimulated the design of alternative strategies of iron-chelating therapy, including orally active iron ...
N F, Olivieri, G M, Brittenham
openaire   +2 more sources

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

The role of magnetic resonance imaging in the evaluation of transfusional iron overload in myelodysplastic syndromes

Revista Brasileira de Hematologia e Hemoterapia, 2015
Myelodysplastic syndromes represent a group of heterogeneous hematopoietic neoplasms derived from an abnormal multipotent progenitor cell, characterized by a hyperproliferative bone marrow, dysplasia of the cellular hemopoietic elements and ineffective ...
Emmanouil Petrou, Sophie Mavrogeni, Vasiliki Karali, Genovefa Kolovou, Marie-Christine Kyrtsonis, Petros P. Sfikakis, Panayiotis Panayiotidis   +6 more
doaj   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Effect of Combined Hydroxyurea and Chelation Therapy in Reducing Serum Ferritin Level, Liver and Spleen Size in Transfusion Dependent Thalassaemia Major Patients.

Journal of Rawalpindi Medical College, 2019
Background: To compare hydroxyurea plus iron chelation therapy with iron chelation therapy alone in controlling iron overload in children with beta thalassaemia major.
Tatheer Zahra, Wajeeha Amber, Itrat Fatima   +2 more
doaj  

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Sex and Gender Differences in Iron Chelation

Biomedicines
Background/Objectives: In the absence of physiological mechanisms to excrete excessive iron, the administration of iron chelation therapy is necessary.
Sarah Allegra, Stefano Comità, Antonella Roetto, Silvia De Francia   +3 more
doaj   +1 more source

Myocardial iron is strongly associated with reproductive function in beta-thalassemic women under chelation therapy

Clinical and Experimental Obstetrics & Gynecology, 2020
Objective: To evaluate gynaecological features of a group of transfusion dependent beta-thalassemic women and to analyze their reproductive function with the morpho-functional features of genital female tract. Materials and Methods: Cross-sectional study
M. A. Castaldi, C. Fulgione, L. Marino, S. G. Castaldi, L. Giugliano, C. Selleri, M. Guida, V. Frega, L. Cobellis, A. Filosa, M. Casale   +10 more
doaj   +1 more source