Results 11 to 20 of about 184,947,225 (237)

Irisin Protects Against Hind Limb Ischemia Reperfusion Injury

Drug Design, Development and Therapy, 2021
The aim of this study was to evaluate the effects of irisin in a murine model of hind limb ischemia reperfusion (I/R).The mice were divided into four groups (n = 6 in each group): control, irisin, ischemia reperfusion (I/R), and irisin-ischemia reperfusion (I-I/R).
Ayşegül Küçük, Yücel Polat, Aydan Kılıçarslan, Nuran Süngü, Hakan Kartal, Ali Doğan Dursun, Mustafa Arslan   +6 more
openaire   +8 more sources

Attenuation of ischemia/reperfusion injury by N-acetylcysteine in a rat hind limb model

Journal of Surgical Research, 2003
Ischemia/reperfusion is a complex set of events with severe pathologic consequences. Reperfusion initiates both the local and systemic damage in part through rapid oxygen generation. N-acetylcysteine (NAC) is a scavenger of free radical species, inhibits neutrophil accumulation, acts as a vasodilator and also improves microcirculation. In present study,
Köksal, Cengiz, Bozkurt, A. Kürşat, Cangel, Uğur, Üstündağ, Nil, Konukoğlu, Dildar, Müsellim, Benan, Sayın, Ayla Gürel   +6 more
openaire   +4 more sources

Effect of picroside II on hind limb ischemia reperfusion injury in rats

Drug Design, Development and Therapy, 2017
Many structural and functional damages are observed in cells and tissues after reperfusion of previously viable ischemic tissues. Acute ischemia reperfusion (I/R) injury of lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery.
Kilic, Yigit, ARSLAN, MUSTAFA, ÖZER, ABDULLAH, KÜÇÜK, Ayşegül, BİLLUR, DENİZ, DURSUN, ALİ DOĞAN, Kartal, Hakan, Kirisci, Mehmet, ZOR, MUSTAFA HAKAN, TATAR, TOLGA   +9 more
openaire   +8 more sources

The effects of amantadine on lung tissue in lower limb ischemia/reperfusion injury model in rats

The Turkish Journal of Thoracic and Cardiovascular Surgery, 2021
This study aims to evaluate the effect of amantadine on lung tissue of after lower limb ischemia/reperfusion injury in rats.A total of 24 Wistar rats were divided into four equal groups including six rats in each: sham group (Group S), amantadine group (Group A), ischemia/reperfusion group (Group I/R), and ischemia/reperfusion + amantadine group (Group
Orhan, Mustafa, Tuna, Ayca Tas, Unal, Yusuf, Arslan, Mustafa, Yazar, Hayrullah, Sezen, Saban Cem, Gozukara, Sezen Irmak, Palabiyik, Onur, Arslan, Mustafa, Yazar, Hayrullah   +9 more
openaire   +4 more sources

Animal stroke models and outcome evaluation: A review. [PDF]

Animal Model Exp Med
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Cariba S, Atkinson HM, Chan AKC.
europepmc   +2 more sources

Protective Role of Sulodexide on Renal Injury Induced by Limb Ischemia-Reperfusion [PDF]

Evidence-Based Complementary and Alternative Medicine, 2021
Background. Though widely known as a potent antithrombin agent with protective effects on the kidney and other remote organs, it is currently ambiguous when it comes to sulodexide’s function on ischemia-reperfusion (I/R) injury. With this research, we pursued to further explore how sulodexide exerts its influence on limb I/R injury, in which ...
Tao Yuan, Ni Yang, Wei Bi, Jinwen Zhang, Xueyan Li, Long Shi, Yang Liu, Xiang Gao   +7 more
openaire   +2 more sources

Q50, an Iron-Chelating and Zinc-Complexing Agent, Improves Cardiac Function in Rat Models of Ischemia/Reperfusion-Induced Myocardial Injury [PDF]

, 2013
Background: Reperfusion of ischemic myocardium may contribute to substantial cardiac tissue damage, but the addition of iron chelators, zinc or zinc complexes has been shown to prevent heart from reperfusion injury.
Faragó, Nóra, Karck, Matthias, Merkely, Béla, Radovits, Tamás, Hirschberg, Kristóf, Korkmaz, Sevil, Hegedűs, Péter, Gyuris, Márió, Li, Shiliang, Puskás, László G., Ózsvári, Béla, Zubarevich, Alina, Weymann, Alexander, Barnucz, Enikő, Kanizsai, Iván, Szabó, Gábor, Szabó, Csaba, Fábián, Gabriella, Loganathan, Sivakkanan   +18 more
core   +2 more sources

The effect of Edaravone on lung injury after lower limb ischemia-reperfusion in a rat model: Biochemical and histopathological insights

Turkish Journal of Vascular Surgery, 2023
Aim: Lower limb ischemia/reperfusion leads to distant organ dysfunction, notably affecting the lungs, resulting in respiratory failure and significant morbidity and mortality.
Mehmet Ceber, Ilker Akar, Ilker Ince, Cemal Aslan, Sameh Alagha   +4 more
doaj   +1 more source

Peculiarities of impairments of absorptive-excretory and glycogen synthesis functions of the liver in the presence of acute blood loss complicated by limb ischemia-reperfusion and their correction by carbacetam

Journal of Education, Health and Sport, 2020
Introduction. Under conditions of massive bleeding from the extremities, both in combat and in peacetime, the only means for salvation is applying tourniquet, which completely stops the arterial blood flow.
I. I. Horban, A. A. Hudyma, R. V. Maksymiv, N. A. Dzhavadova   +3 more
doaj   +1 more source

Ischemic postconditioning ameliorates acute kidney injury induced by limb ischemia/reperfusion via transforming TLR4 and NF-κB signaling in rats

Journal of Orthopaedic Surgery and Research, 2021
Background The present study investigated the influence of ischemic postconditioning (I-postC) on the adjustment of renal injury after limb ischemia-reperfusion (I/R) injury, to elucidate the mechanisms of the Toll-like receptor 4 (TLR 4)/NF-κB signaling
Zhongdi Liu, Wei Huang, Yifan Chen, Zhe Du, Fengxue Zhu, Tianbing Wang, Baoguo Jiang   +6 more
doaj   +1 more source