Results 41 to 50 of about 184,947,225 (237)

Effect of valproic acid upon skeletal muscle subjected to prolonged tourniquet application

Trauma Surgery & Acute Care Open, 2023
Background Valproic acid (VPA), a histone deacetylase inhibitor, has shown improved outcomes when used as a pharmaceutical intervention in animal studies of hemorrhage, septic shock, and combined injuries.
Robert Moritz, Lee Mangum, Chet Voelker, Gerardo Garcia, Joseph Wenke   +4 more
doaj   +1 more source

A reproducible method for biochemical, histological and functional assessment of the effects of ischaemia–reperfusion syndrome in the lower limbs

Scientific Reports, 2021
Current methodology described to mimic lower limb ischaemia–reperfusion injury (LL-IRI) does not accurately define the procedures and pressures exerted to induce and maintain ischaemia.
Iñigo Cearra, Borja Herrero de la Parte, Diana Isabel Moreno-Franco, Ignacio García-Alonso   +3 more
doaj   +1 more source

Dual acellular subnormothermic machine perfusion for enhanced uterus preservation in a swine model. [PDF]

Acta Obstet Gynecol Scand
In a porcine uterus transplantation model, subnormothermic machine perfusion reduced graft edema and better‐preserved post‐reperfusion contractility than static cold storage, highlighting its potential for uterus preservation, assessment, and future graft‐conditioning applications.
Cabanel L, Oubari H, Ellis BW, Dion L, Lavoué V, Sousa C, Van Dieren L, Morel O, Randolph MA, Cetrulo CL, Uygun K, Lellouch AG, Berkane Y, Uygun BE.   +13 more
europepmc   +2 more sources

Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion [PDF]

, 2011
Magnetic resonance imaging (MRI) with oxygen challenge (T2* OC) uses oxygen as a metabolic biotracer to define penumbral tissue based on CMRO2 and oxygen extraction fraction. Penumbra displays a greater T2* signal change during OC than surrounding tissue.
Robertson, Craig A, Robertson, Craig A., William M Holmes, Celestine Santosh, Macrae, I Mhairi, McCabe, Chris, Maria del Rosario Lopez-Gonzalez, Barrie Condon, Keith W Muir, Lopez Gonzalez, Maria del, Lindsay Gallagher, Holmes, William M., Christopher McCabe, Santosh, Celestine, Craig A Robertson, Lopez-Gonzalez, Maria del Rosario, Holmes, William M, Macrae, I. Mhairi, I Mhairi Macrae, Gallagher, Lindsay, Muir, Keith W, Condon, Barrie, McCabe, Christopher, Muir, Keith W.   +23 more
core   +1 more source

Cepharanthine alleviates liver injury in a rodent model of limb ischemia–reperfusion

Acta Anaesthesiologica Taiwanica, 2016
Limb ischemia-reperfusion (I/R) causes remote organ injury (e.g., liver injury). Oxidation and inflammation are crucial mechanisms. We investigated the effects of cepharanthine, a potent antioxidative and anti-inflammatory drug, on alleviating liver injury induced by limb I/R.Twenty-four adult male Sprague-Dawley rats were randomized to receive sham ...
Chang, Yin-Kuang, Huang, Su-Cheng, Kao, Ming-Chang, Huang, Chun-Jen   +3 more
openaire   +2 more sources

Role of cation gradients in hypercontracture of myocytes during simulated ischemia and reperfusion [PDF]

, 1993
We examined the relationship between transsarcolemmal cation gradients and hypercontracture of cardiac myocytes in ischemia and reperfusion using adult rat ventricular myocytes superfused with buffer mimicking normal or ischemic extracellular fluid ...
J. P. Navas, Marsh, J. D., R. A. Kelly, J. D. Marsh, Krämer, Bernhard K., Kelly, R. A., Nishida, M., T. W. Smith, Smith, T. W., M. Nishida, B. Kraemer, Borzak, S., S. Borzak, Navas, J. P.   +13 more
core   +1 more source

Monitoring of lung edema by microwave reflectometry during lung ischemia-reperfusion injury in vivo [PDF]

, 2006
It is still unclear whether lung edema can be monitored by microwave reflectometry and whether the measured changes in lung dry matter content (DMC) are accompanied by changes in PaO(2) and in pro-to anti-inflammatory cytokine expression (IFN-gamma and ...
Metzger, R. P., Gross, W., Nowak, K., Schaefer, M., Post, S., Gebhard, M. M., Hohenberger, P.   +6 more
core   +1 more source

Aprotinin ameliorates ischemia/reperfusion injury in a rat hind limb model

Vascular Pharmacology, 2004
The aim of the study was to investigate the protective effect of aprotinin in a rat hind limb ischemia/reperfusion (I/R) model. A well-known antioxidant, alpha-tocopherol, was also tested for comparison. Ischemia was induced for 4 h by vascular clamping of the iliac arteries of 24 Sprague-Dawley rats, followed by 1 h of reperfusion.
Köksal, Cengiz, Bozkurt, A. Kürşat, Şirin, Gökçe, Konukoğlu, Dildar, Üstündağ, Nil   +4 more
openaire   +4 more sources

Prednisolone as preservation additive prevents from ischemia reperfusion injury in a rat model of orthotopic lung transplantation [PDF]

, 2013
The lung is, more than other solid organs, susceptible for ischemia reperfusion injury after orthotopic transplantation. Corticosteroids are known to potently suppress pro-inflammatory processes when given in the post-operative setting or during ...
Haitham Mutlak, Paulus, Patrick, Mutlak, Haitham, Johannes Holfeld, Haitham Mutlak (452006), Sabine Tacke (318720), David Stay (452009), Patrick Paulus, Holfeld, Johannes, Urbschat, Anja, Christin Reissig, Pia Alexandra Ockelmann, Reissig, Christin, Zacharowski, Kai, Tacke, Sabine, Bertram Scheller (318724), Stay, David, Bertram Scheller, Ockelmann, Pia Alexandra, Scheller, Bertram, Kai Zacharowski (77285), Sabine Tacke, Johannes Holfeld (318725), Patrick Paulus (318716), Anja Urbschat, Kai Zacharowski, Christin Reissig (452008), Anja Urbschat (318726), David Stay, Pia Alexandra Ockelmann (452007), Tacke Sabine, Stay David, Urbschat Anja, Reissig Christin, Ockelmann Pia Alexandra, Paulus Patrick, Zacharowski Kai, Mutlak Haitham, Scheller Bertram, Holfeld Johannes   +39 more
core   +2 more sources

Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle

BMC Complementary and Alternative Medicine, 2007
Background Salvia leriifolia have been shown to decrease ischemia-reperfusion (I/R) injury in brain tissues. In this study, the effects of S. leriifolia aqueous and ethanolic extracts were evaluated on an animal model of I/R injury in the rat hind limb ...
Nassiri-Asl Marjan, Hosseini Azar, Hosseinzadeh Hossein, Sadeghnia Hamid-Reza   +3 more
doaj   +1 more source