Results 91 to 100 of about 24,379 (223)

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

Multiple Isocyanide insertions promoted by protic and Lewis acids

Tetrahedron Chem
The protonation, or Lewis Acid complexation, of electrophiles can trigger the sequential insertion of two or more isocyanides resulting in valuable iminonitriles or heterocycles.
John Kornfeind, Fraser F. Fleming
doaj   +1 more source

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source

Synthese und aktivitätsbasierte Proteinprofilierung identifizieren die Aldo‐Keto‐Reduktase 1C3 als Zielprotein der Myxoglucamide

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Myxoglucamid A – ein neuartiges, aus Myxobakterien isoliertes Glykolipopeptid – wurde erstmals totalsynthetisch hergestellt. Mittels aktivitätsbasierter Proteinprofilierung (ABPP) wurde die Aldo‐Keto‐Reduktase 1C3 (AKR1C3) als primäres Zielprotein in menschlichen Zellen identifiziert.
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Anomalous Stiff Backbones of Helical Poly(phenyl isocyanide) Derivatives

, 2016
Anomalous Stiff Backbones of Helical Poly(phenyl isocyanide ...
Shin-ichiro Sakurai (2164015), Kento Okoshi (1850734), Kanji Nagai (208002), Eiji Yashima (1569460), Takashi Kajitani (249919)   +4 more
core   +1 more source

Blue Phosphorescence from Mixed Cyano−Isocyanide Cyclometalated Iridium(III) Complexes

, 2016
The synthesis, structure, and photophysical and electrochemical properties of cyclometalated iridium complexes with ancillary cyano and isocyanide ligands are described.
Peter Y. Zavalij (616937), Jianmin Shi (2501899), Eric Forsythe (2282443), David C. Morton (2501896), Kenneth Dedeian (2501893)   +4 more
core   +2 more sources

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, Volume 65, Issue 41, 5 October 2026.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Novel Isocyanide-Based Four-Component Reaction: A Facile Synthesis of Fully Substituted 3,4-Dihydrocoumarin Derivatives

, 2016
A novel isocyanide-based four-component reaction between a 2-hydroxybenzaldehyde, Meldrum’s acid, an isocyanide, and an aromatic or an aliphatic alcohol efficiently provide 3,4-dihydrocoumarin derivatives in good to excellent yields without using any ...
Hamid Reza Khavasi (606027), Ahmad Shaabani (1821601), Ali Hossein Rezayan (2358841), Afshin Sarvary (2358844), Ebrahim Soleimani (2135932)   +4 more
core   +3 more sources

Optical Investigation of 2-amino-7-isocyanofluorene, a Novel Blue-Emitting Solvatochromic Dye

Colorants
Smart solvatochromic isocyano-aminoarenes (ICAArs) have been gaining attention owing to their unique photophysical, antifungal and anticancer properties.
Bence Kontra, Zoltán Mucsi, László Vanyorek, Miklós Nagy   +3 more
doaj   +1 more source

Copper(I) Isocyanide Complexes of Highly Fluorinated Poly(pyrazolyl)borates

, 2016
Copper(I) Isocyanide Complexes of Highly Fluorinated Poly(pyrazolyl ...
Wiechang Jin (2648035), H. V. Rasika Dias (840254), Hui-Ling Lu (2970930), John D. Gorden (1359699)   +3 more
core   +1 more source