Results 81 to 90 of about 22,422 (224)

Phase‐Transfer‐Catalyzed Interrupted Barton–Zard Reaction Between Electron‐Deficient Indoles and Benzophenone‐Derived Isocyanides

European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.
A cascade reaction under phase‐transfer conditions between 3‐nitro indoles and isocyanomethylene dibenzenes affords the construction of pyrrolo[3,4‐b]indole cores. Control experiments provide insight into moderate product yields and clarify why the reaction is not amenable to asymmetric induction. A cascade reaction enabling the construction of pyrrolo[
Ana Mikleušević, Ines Bašić, Mateja Matišić, Josip Rešetar, Matija Gredičak   +4 more
wiley   +1 more source

Exploiting the Reactivity of Isocyanide: Coupling Reaction between Isocyanide and Toluene Derivatives Using the Isocyano Group as an N1 Synthon

, 2016
An unusual oxidative coupling reaction of isocyanide and toluene derivatives using tetrabutylammonium iodide (TBAI) as a catalyst is disclosed. The experimental results and mechanistic study show that the isocyano group acts formally as an N1 synthon ...
Feng Li (30515), Jianxiong Li (518032), Chunju Li (1408624), Jian Li (41607), Xueshun Jia (1408627), Zhiqiang Liu (182265), Xinglu Zhang (2593240)   +6 more
core   +1 more source

A New Method for the Synthesis of 1-(1-Isocyanoethyl)adamantane

Molbank
A novel single-step method has been developed for the synthesis of 1-(1-isocyanoethyl)adamantane from 1-(1-adamantylethyl)amine, chloroform, and t-BuOK, in a dichloromethane/tert-butanol (1:1) medium, yielding 92%, which is 27% higher compared to the ...
Dmitry Pitushkin, Gennady Butov
doaj   +1 more source

A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions

Frontiers in Chemistry, 2019
A novel, efficient and environmentally friendly approach has been developed for the synthesis of biologically important bis-heterocyclic oxazepine-quinazolinone derivatives.
Shabnam Shaabani, Ahmad Shaabani, Monika Kucerakova, Michal Dusek   +3 more
doaj   +1 more source

Cleavable β-cyanoethyl isocyanide in the Ugi tetrazole reaction [PDF]

, 2016
β-Cyanoethyl isocyanide is introduced as a cleavable isocyanide in the Ugi tetrazole reaction. Eleven examples are described that exhibit a broad scope and are obtained in good overall yields.
Kroon, Edwin, Dömling, Alexander, Katarzyna Kurpiewska (1508353), Alexander Dömling (1312329), Alexander Dömling, Edwin Kroon, Kalinowska-Tłuścik, Justyna, Edwin Kroon (3110565), Justyna Kalinowska-Tłuścik, Kurpiewska, Katarzyna, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik (1508347)   +11 more
core   +1 more source

Facile synthesis of 1H-imidazo[1,2-b]pyrazoles via a sequential one-pot synthetic approach

Beilstein Journal of Organic Chemistry, 2014
5-Aminopyrazole-4-carbonitrile and ethyl 5-aminopyrazole-4-carboxylate, as potential trifunctional building blocks are introduced in a facile, chemo- and regioselective multicomponent assembly of imidazo[1,2-b]pyrazoles via the Groebke–Blackburn–Bienaymé
András Demjén, Márió Gyuris, János Wölfling, László G. Puskás, Iván Kanizsai   +4 more
doaj   +1 more source

Crystal structure of heptakis(2,6-dimethylphenyl isocyanide-κC)vanadium(I) iodide

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title salt, [V(C9H9N)7]+I− or [V(CNXyl)7]+I− (Xyl is 2,6-dimethylphenyl), crystallized from tetrahydrofuran at low temperatures after reacting (Et4N)+[V(CO)6]−, excess of CNXyl and iodine. The complex cation and the two crystallographically different
Mikhail E. Minyaev, John E. Ellis
doaj   +1 more source

Triple-Consecutive Isocyanide Insertions with Aldehydes: Synthesis of 4‑Cyanooxazoles

, 2023
An efficient TMSOTf-promoted selective triple consecutive insertions of tert-butyl isocyanide into aldehydes has been developed, affording pharmacological interesting 4-cyanooxazoles in high yields in a one pot manner.
Chang-Hua Ding, Shaohang Lu (14515168), Shaohang Lu, Bin Xu, Chang-Hua Ding (1701772), Bin Xu (10691)   +5 more
core   +1 more source

Multiple Isocyanide insertions promoted by protic and Lewis acids

Tetrahedron Chem
The protonation, or Lewis Acid complexation, of electrophiles can trigger the sequential insertion of two or more isocyanides resulting in valuable iminonitriles or heterocycles.
John Kornfeind, Fraser F. Fleming
doaj   +1 more source

Developing Isocyanide Methodology

, 2018
Isocyanides are privileged structures, found in bioactive compounds derived from natural sources and pervasive in the synthesis of pharmacologically relevant compounds.
Chao, Allen
core