Results 81 to 90 of about 2,381,535 (223)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Molecular basis of rifampin and isoniazid resistance in Mycobacterium bovis strains isolated in Sardinia, Italy [PDF]

, 2001
Fourteen of 22 (68%) Mycobacterium bovis strains isolated from cattle in Sardinia were found to be resistant to rifampin and isoniazid. Analysis of the rpoB and the katG, oxyR-ahpC, and inhA gene regions of these strains was performed in order to ...
Delogu, Giovanni, Fadda, Giovanni, M. La Sorda, G. Delogu, P. Molicotti, M. Sanguinetti, Sanguinetti, Maurizio, La Sorda, Marilena, S. Boccia, S. Zanetti, Romano, Lucio, G. Fadda, Boccia, Stefania, L. A. Sechi, L. Romano, G. Leori, Delogu G, Leori G, Sechi LA, Zanetti S, Romano L, Fadda G, Molicotti P, Boccia S, La Sorda M, Sanguinetti M   +25 more
core   +1 more source

Bioactivity profiling of linear venom peptides from Italian small wood‐scorpion (Euscorpius italicus)

Pest Management Science, EarlyView.
Functional screening pipeline of venom peptides from Euscorpius italicus reveal their activity towards globally important pest insects, bacteria, and cells – providing insight on the potential and function of arachnid venom peptides. Abstract BACKGROUND Rising host‐expansion and the global spread of pest insects, confront agricultural sectors with ...
Maurice Pierry, Ludwig Dersch, Jonas Krämer, Lennart Schulte, Ignazio Avella, Tobias Kessel, Kornelia Hardes, Michael Marner, Jens Grotmann, Maximilian Seip, Till F. Schäberle, Tim Lüddecke   +11 more
wiley   +1 more source

White light emitting molecular logic gates

Smart Molecules, EarlyView.
White light emitting smart molecules with Boolean logic computing ability are surveyed. Abstract White light emitting (WLE) materials are of considerable interest with commercial and societal applications in video displays and lighting devices. A characteristic property of WLE materials is the luminescence profile spanning from 380 to 700 nm.
Davide Benedetto Tiz, Massimo Catania, David C. Magri   +2 more
wiley   +1 more source

Comparison of PCR-RFLP and Allele Specific-PCR and sequencing in rapid diagnosis of isoniazid resistance in clinical isolates of Mycobacterium tuberculosis

Iranian South Medical Journal, 2015
Background: Isoniazid is from the first-line drugs for treatment of tuberculosis. Resistance to Isoniazid is increasingly reported. In the study, molecular methods for rapid detection of isoniazid resistance in clinical isolates of Mycobacterium ...
Hamid Bornasi, Mohammad Arjomandzadegan, Ahmadreza Bahrmand, Alireza Hadizadeh Tasbiti, Azam Ahmadi, Maryam Tayeboon   +5 more
doaj  

Evaluation of the frequency of resistance to 2 drugs (Isoniazid and Rifampin) by molecular investigation and it's risk factors in new cases of smear positive pulmonary tuberculosis in health centers under the cover of Jundishapur University of Medical Sciences in 2017

Journal of Family Medicine and Primary Care, 2020
Introduction: Despite the great efforts to control tuberculosis (TB), the disease is still one of the major health challenges throughout the world. The basic treatment for TB is drug therapy.
Shokrollah Salmanzadeh, Masoumeh Karamian, Seyed Mohammad Alavi, Roohangiz Nashibi   +3 more
doaj   +1 more source

THE TERRITORIALIZATION OF ANGOLA'S REAL ESTATE FRONTIER: How Private‐led Housing Developments are Reshaping the Outskirts of Luanda

International Journal of Urban and Regional Research, EarlyView.
Abstract Africa is recognized as the final frontier for urbanization and capitalism. Following a long wave of massive loans to promote state‐led developments, small private foreign and local developers are transforming the urban landscape on the outskirts of Luanda, forging partnerships with Angola's national and local governments and developing an ...
Higor Carvalho
wiley   +1 more source

The Usefulness of the BD MAX MDR-TB Molecular Test in the Rapid Diagnosis of Multidrug-Resistant Tuberculosis

Pathogens
Tuberculosis (TB), primarily caused by Mycobacterium tuberculosis complex (MTBC), remains a global health challenge and can lead to severe pulmonary and extrapulmonary complications.
Tomasz Bogiel, Edyta Dolska, Małgorzata Zimna, Kornelia Nakonowska, Dorota Krawiecka, Renata Żebracka, Maciej Pochowski, Agnieszka Krawczyk   +7 more
doaj   +1 more source

Prurigo Pigmentosa – an increasingly diagnosed dermatological condition associated with ketogenic diet

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
SUMMARY Prurigo pigmentosa (PP) is a rare inflammatory dermatosis, clinically characterized by intensely pruritic, erythematous papules and papulovesicles, with reticular hyperpigmentation upon healing. We herein report four cases in adults of different ethnic backgrounds, in which the disease was associated with ketogenic metabolic states due to ...
Antigona Aliu, Milan Vidakovic, Marcel Krauß, Julia Hyun, Frank Oellig, Thilo Gambichler, Valentina Laura Müller, Alexander Kreuter   +7 more
wiley   +1 more source

MOLECULAR MECHANISMS OF ISONIAZID RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS AND MYCOBACTERIUM BOVIS

, 1995
Isoniazid (INH) has been used extensively in the treatment of tuberculosis since 1952. Subsequent to the implementation of isoniazid chemotherapy, drug-resistant strains of Mycobacterium tuberculosis began to be reported.
Rouse, David A.
core   +1 more source