Results 91 to 100 of about 32,281 (298)

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides [PDF]

, 2013
The enoyl acyl-carrier protein reductase (ENR) enzyme is harbored within the apicoplast of apicomplexan parasites providing a significant challenge for drug delivery, which may be overcome through the addition of transductive peptides, which facilitates ...
Baldock, Bhargava, Charalambidis, Cheng, Chhibber, Cohen, David W. Rice, Fomovska, Fomovska, Freundlich, Goodman, Goodsell, Guex, Gustavo A. Afanador, Heath, Himo, Jennifer M. Auschwitz, Jozef Stec, Lai, Levy, Liskey, Lu, Magnuson, Maity, Mark R. Hickman, Martin J. McPhillie, McFadden, McLeod, McMurry, Miller, Muench, Patty J. Lee, Perozzo, Rima McLeod, Rozwarski, Samuel, Sean T. Prigge, Smith, Spalding, Stephen P. Muench, Surolia, Susan E. Leed, Tipparaju, Ward, Wright, Xia, Ying Zhou, Yu   +47 more
core   +1 more source

Hexacarbonylmolybdenum-induced Reaction of Isoxazoles. Cycloaddition of Isoxazoles with Acetylenic Esters and Related Reactions [PDF]

Bulletin of the Chemical Society of Japan, 1985
Abstract In the presence of hexacarbonylmolybdenum, substituted isoxazoles undergo a cycloaddition reaction with dimethyl acetylenedicarboxylate across the C-4–C-5 bond to give 3,4-bis(methoxycarbonyl)pyridine derivatives. In a similar cycloadition of isoxazoles with methyl propiolate, 4-(methoxycarbonyl)pyridine derivatives were also ...
Tomoshige Kobayashi, Makoto Nitta
openaire   +3 more sources

Benzochalcogenodiazoles, synthesis and applications in medicinal chemistry and photomedicine.

European Journal of Organic Chemistry, Accepted Article.
Benzochalcogenodiazoles BXDs (BOD: benzoxadiazole, BTD: benzothiadiazole, or BSD: benzoselenadiazole) are aromatic bicyclic compounds, containing chalcogen atoms, with applications ranging from material to medicinal chemistry. The recent developments in their preparation and functionalization are taking advantage of new methodologies such as C‐H ...
Jean-Elie Zheng, Xavier Franck, Thibault Gallavardin   +2 more
wiley   +1 more source

Sterically Facilitated Intramolecular Nucleophilic NMe₂ Group Substitution in the Synthesis of Fused Isoxazoles: Theoretical Study

Molecules, 2020
The influence of steric repulsion between the NMe2 group and a second ortho-(peri-)substituent in the series of 1-dimethylaminonaphthalene and N,N-dimethylanilene ortho-oximes on the ease of the NMe2 group’s intramolecular nucleophilic substitution is ...
Alexander S. Antonov, Elena Yu Tupikina, Valerii V. Karpov, Valeriia V. Mulloyarova, Victor G. Bardakov   +4 more
doaj   +1 more source

InCl3-​assisted synthesis and cytotoxic studies of some novel heteroaryl thiazoles [PDF]

, 2013
Heteroaryl thiazoles were synthesized by the Hantzsch reaction of various α-​bromoketones with aryl thioureas using InCl3 as a catalyst in a shorter reaction time. The synthesized compds.
Boggavarapu Chand, S.G., Boregowda Puttaraju, K., Kalegowda Shivashankar, ., Ramamohan Reddy, K., Rasal Vijaykumar, P., Venkata Vivek, P.N.   +5 more
core  

Effects of perampanel on bone health in adult patients with epilepsy

Epilepsia Open, EarlyView.
Abstract Objective The objective was to assess the effects of perampanel (PER) on bone metabolism and bone mineral density (BMD) in adult patients with epilepsy. Methods This retrospective study included consecutive patients admitted to the Epilepsy Center of Sichuan Provincial People's Hospital from January 2023 to June 2024.
Mingxing Yu, Nana Zhang, Chunyan Chen, Yuxuan He, Jing Meng, Wen Luo, Yi Liang, Yi Guo, Liang Yu   +8 more
wiley   +1 more source

Crystal structure of ethyl 3-(4-chlorophenyl)-5-[(E)-2-(dimethylamino)ethenyl]-1,2-oxazole-4-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C16H17ClN2O3, two molecules, A and B, with different conformations, comprise the asymmetric unit. In molecule A, the C=O group of the ester points away from the benzene ring [C—C—C=O = −170.8 (3)°], whereas in molecule B, it points
Ilya Efimov, Pavel Slepukhin, Vasiliy Bakulev   +2 more
doaj   +1 more source

Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation [PDF]

, 2015
1,2,3-Triazole-based heterocycles have previously been shown to possess significant anticancer activity in various tumor models. In the present study, we attached a 1,2,3-triazole moiety to the third position of a 1,2-benzisoxazole heterocycle via copper(
Anusha, S., Ashwini, N., Basappa, ., Bender, A., Fuchs, J.E., Garg, M., Kanojia, D, Koeffler, H.P., Madan, V., Mohan, C.D., Rakesh, K.S., Rangappa, K.S., Rangappa, S., Swaroop, T.R.   +13 more
core   +1 more source

Über α‐Methyl‐isoxazol [PDF]

Berichte der deutschen chemischen Gesellschaft, 1909
n ...
openaire   +2 more sources

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

Medicinal Research Reviews, EarlyView.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra, Zoltán Mucsi, Janez Ilaš, Petra Dunkel   +3 more
wiley   +1 more source