Results 91 to 100 of about 24,568 (261)
Terpenes and Terpenoids: How can we use them?
European Journal of Organic Chemistry, Volume 28, Issue 24, June 24, 2025.The transition from petroleum‐based to renewable bio‐based chemicals has led to increased interest in terpenes and terpenoids. This overview highlights their chemistry, focusing on their reactivity and applications in polymerizations, total syntheses, pharmaceuticals, and bio‐based chemical conversions; promoting sustainable and green chemical ...
Jay Hanssens +3 more
wiley +1 more source
3-N-oxalyl-L-2,3-diaminopropanoic acid, a multifunctional plant metabolite of toxic reputation [PDF]
, 2006 3-N-oxalyl-L-2,3-diaminopropanoic acid (beta-ODAP) is a neuroexcitatory non- protein amino acid identified in grass pea (Lathyrus sativus L.) and in ginseng (Panax spp).
Ikegami, Fumio +3 more
core +1 more source
Isoxazole Derivatives as Regulators of Immune Functions [PDF]
Molecules, 2018 In this review, we present reports on the immunoregulatory properties of isoxazole derivatives classified into several categories, such as immunosuppressive, anti-inflammatory, immunoregulatory, and immunostimulatory compounds. The compounds were tested in various models using resident cells from rodents and humans, cell lines, and experimental animal ...
Michał Zimecki +2 more
openaire +3 more sources
Benzochalcogenodiazoles, Synthesis, and Applications in Medicinal Chemistry and Photomedicine
European Journal of Organic Chemistry, Volume 28, Issue 23, June 23, 2025.Benzochalcogenodiazoles (BXD) including benzoxadiazoles, benzothiadiazoles, and benzoselenadiazoles are initially mainly designed for optoelectronic materials as electron‐deficient cores. Nevertheless, they are now extending their application to biology.
Jean‐Elie Zheng +2 more
wiley +1 more source
Identification of a novel class of autotaxin inhibitors through cross-screening [PDF]
, 2015 Three novel series were generated in order to mimic the pharmacophoric features displayed by lead compound AM095, a Lysophosphatidic acid (LPA1) receptor antagonist. Biological evaluation of this array of putative LPA1 antagonists led us to the discovery
Budd, David C. +8 more
core +1 more source
Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis
Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley +1 more source
A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons [PDF]
, 2018 Mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). FUS is a multifunctional protein involved in the biogenesis and activity of several types of RNAs, and its role in the pathogenesis of ALS may involve both direct effects of
Biscarini, Silvia +10 more
core +2 more sources
Cortical Excitability Before and After Long‐Term Perampanel Treatment for Epilepsy
Annals of Clinical and Translational Neurology, Volume 12, Issue 6, Page 1256-1264, June 2025.ABSTRACT Objective Antiseizure medications (ASMs), which may influence cortical excitability, are the mainstay of epilepsy treatment. Transcranial magnetic stimulation (TMS) helps evaluate cortical excitability. We assessed changes in TMS responses using serial TMS measurements in people treated with an adjunctive noncompetitive AMPA‐receptor ...
Robert M. Helling +6 more
wiley +1 more source
Synthesis of Curcumin Derivatives and Analysis of Their Antitumor Effects in Triple Negative Breast Cancer (TNBC) Cell Lines [PDF]
, 2019 We analyzed antitumor effects of a series of curcumin analogues. Some of them were obtained by reaction of substitution involving the two phenolic OH groups of curcumin while the analogues with a substituent at C-4 was prepared following an original ...
Barattucci A +5 more
core +1 more source