Results 101 to 110 of about 24,568 (261)
GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou+18 more
wiley +1 more source
Phototauntomerism of o-nitrobenzyl compounds: o-quinonoid aci-nitro species studied by matrix isolation and DFT calculations [PDF]
Photolyses of 2-nitrobenzyl methyl ether and 2-nitrotoluene with 254 nm light have been investigated in Ar and N2 matrices at 12 K, and have been found to give o-quinonoid aci-nitro species as the primary photoproducts, along with other products.
Dunkin, Ian R.+3 more
core +1 more source
The efficient and robust enantioselective organocatalytic methodology was developed for the conjugate addition of isoxazol‐5(4H)‐ones to aurone‐derived azadienes. This approach provided products featuring benzofuran and isoxazole rings with high yields and enantioselectivities.
Ricardo Torán+4 more
wiley +1 more source
New Heterocyclic Syntheses from Pyridinethiones: an Efficient Route for the Syntheses of Some Novel Azo Derivatives of Thieno[2,3-b]pyridine as Potential Anti-bacterial and Anti-cancer Agents [PDF]
Derivatives of a heterocyclic system 3-(pyrrol-1-yl)thieno[2,3-b]pyridine 5 and 6 carrying various substituents in the position 2 were synthesized. Some of these products were used to build up a variety of nitrogen- and/or oxygen-containing heterocyclic ...
ElSawy, Karim M.+2 more
core
A simple approach was developed for the synthesis of methyl 4-imidazolylpyrrole-2-carboxylates from easily available compounds, 5-methoxyisoxazoles and phenacylimidazolium salts under hybrid Fe(II)/Et3N relay catalysis.
Ekaterina E. Galenko+4 more
doaj +1 more source
Effects of perampanel on bone health in adult patients with epilepsy
Abstract Objective The objective was to assess the effects of perampanel (PER) on bone metabolism and bone mineral density (BMD) in adult patients with epilepsy. Methods This retrospective study included consecutive patients admitted to the Epilepsy Center of Sichuan Provincial People's Hospital from January 2023 to June 2024.
Mingxing Yu+8 more
wiley +1 more source
We proposed a new approach to estimate the minimum efficacious doses of a food ingredient using a PBPK model. The study was conducted in two parts: Study 1 involved the optimization of the PBPK model based on plasma and blood EGT concentration profiles.
Hitoshi Okumura+7 more
wiley +1 more source
Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides [PDF]
A series of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzenesulfonamide derivatives (1–32) was synthesized and evaluated for its in vitro antimicrobial, antiviral and cytotoxic activities.
Clercq, Erik De+6 more
core +2 more sources
Reactions of β-azolyl enamines and nitrile oxides were studied by both experimental and theoretical methods. (E)-β-(4-Nitroimidazol-5-yl), (5-nitroimidazol-4-yl) and isoxazol-5-yl enamines smoothly react regioselectively at room temperature in dioxane ...
Ilya V. Efimov+10 more
doaj +1 more source
Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda+5 more
wiley +1 more source