Results 101 to 110 of about 24,568 (261)

GLS1‐Mediated Redundancy in Glutamate Accelerates Arterial Calcification via Activating NMDAR/Ca2+/β‐Catenin Pathway

Advanced Science, Volume 12, Issue 21, June 5, 2025.
GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou, Bing Dong, Dayu He, Jianshuai Ma, Yun Kong, Huijin Zhu, Chen Xie, Tiecheng Yang, Xin Zhen, Zhengzhipeng Zhang, Zhaohui He, Jinkun Cheng, Aoran Huang, Jie Chen, Ruo Wu, Huiyong Yin, Yanlian Chen, Jun Tao, Hui Huang   +18 more
wiley   +1 more source

Phototauntomerism of o-nitrobenzyl compounds: o-quinonoid aci-nitro species studied by matrix isolation and DFT calculations [PDF]

, 2001
Photolyses of 2-nitrobenzyl methyl ether and 2-nitrotoluene with 254 nm light have been investigated in Ar and N2 matrices at 12 K, and have been found to give o-quinonoid aci-nitro species as the primary photoproducts, along with other products.
Dunkin, Ian R., Gebicki, Jerzy, Kiszka, Mariusz, Sanin-Leira, David   +3 more
core   +1 more source

Organocatalytic Enantioselective Conjugate Addition of Isoxazol‐5(4H)‐Ones to Aurone‐Derived Azadienes

ChemCatChem, Volume 17, Issue 12, June 23, 2025.
The efficient and robust enantioselective organocatalytic methodology was developed for the conjugate addition of isoxazol‐5(4H)‐ones to aurone‐derived azadienes. This approach provided products featuring benzofuran and isoxazole rings with high yields and enantioselectivities.
Ricardo Torán, Jordi Torró, Amparo Sanz‐Marco, Carlos Vila, Gonzalo Blay   +4 more
wiley   +1 more source

New Heterocyclic Syntheses from Pyridinethiones: an Efficient Route for the Syntheses of Some Novel Azo Derivatives of Thieno[2,3-b]pyridine as Potential Anti-bacterial and Anti-cancer Agents [PDF]

, 2008
Derivatives of a heterocyclic system 3-(pyrrol-1-yl)thieno[2,3-b]pyridine 5 and 6 carrying various substituents in the position 2 were synthesized. Some of these products were used to build up a variety of nitrogen- and/or oxygen-containing heterocyclic ...
ElSawy, Karim M., Gaber, Hatem M., Sherif, Sherif M.   +2 more
core  

Fe(II)/Et3N-Relay-catalyzed domino reaction of isoxazoles with imidazolium salts in the synthesis of methyl 4-imidazolylpyrrole-2-carboxylates, its ylide and betaine derivatives

Beilstein Journal of Organic Chemistry, 2015
A simple approach was developed for the synthesis of methyl 4-imidazolylpyrrole-2-carboxylates from easily available compounds, 5-methoxyisoxazoles and phenacylimidazolium salts under hybrid Fe(II)/Et3N relay catalysis.
Ekaterina E. Galenko, Olesya A. Tomashenko, Alexander F. Khlebnikov, Mikhail S. Novikov, Taras L. Panikorovskii   +4 more
doaj   +1 more source

Effects of perampanel on bone health in adult patients with epilepsy

Epilepsia Open, Volume 10, Issue 3, Page 822-830, June 2025.
Abstract Objective The objective was to assess the effects of perampanel (PER) on bone metabolism and bone mineral density (BMD) in adult patients with epilepsy. Methods This retrospective study included consecutive patients admitted to the Epilepsy Center of Sichuan Provincial People's Hospital from January 2023 to June 2024.
Mingxing Yu, Nana Zhang, Chunyan Chen, Yuxuan He, Jing Meng, Wen Luo, Yi Liang, Yi Guo, Liang Yu   +8 more
wiley   +1 more source

Estimation and Validation of an Effective Ergothioneine Dose for Improved Sleep Quality Using Physiologically Based Pharmacokinetic Model

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
We proposed a new approach to estimate the minimum efficacious doses of a food ingredient using a PBPK model. The study was conducted in two parts: Study 1 involved the optimization of the PBPK model based on plasma and blood EGT concentration profiles.
Hitoshi Okumura, Yudai Araragi, Kentaro Nishioka, Reiya Yamashita, Toshihide Suzuki, Hiroshi Watanabe, Yukio Kato, Norihito Murayama   +7 more
wiley   +1 more source

Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides [PDF]

, 2014
A series of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzenesulfonamide derivatives (1–32) was synthesized and evaluated for its in vitro antimicrobial, antiviral and cytotoxic activities.
Clercq, Erik De, Kumar, Mahesh, Majeed, Abu Bakar Abdul, Mani, Vasudevan, Mishra, Rakesh Kumar, Narasimhan, Balasubramanian, Ramasamy, Kalavathy   +6 more
core   +2 more sources

Combined experimental and theoretical studies of regio- and stereoselectivity in reactions of β-isoxazolyl- and β-imidazolyl enamines with nitrile oxides

Beilstein Journal of Organic Chemistry, 2016
Reactions of β-azolyl enamines and nitrile oxides were studied by both experimental and theoretical methods. (E)-β-(4-Nitroimidazol-5-yl), (5-nitroimidazol-4-yl) and isoxazol-5-yl enamines smoothly react regioselectively at room temperature in dioxane ...
Ilya V. Efimov, Marsel Z. Shafikov, Nikolai A. Beliaev, Natalia N. Volkova, Tetyana V. Beryozkina, Wim Dehaen, Zhijin Fan, Viktoria V. Grishko, Gert Lubec, Pavel A. Slepukhin, Vasiliy A. Bakulev   +10 more
doaj   +1 more source

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, Volume 292, Issue 11, Page 2865-2881, June 2025.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source