Results 31 to 40 of about 24,568 (261)

PAR2 modulators derived from GB88 [PDF]

, 2016
PAR2 antagonists have potential for treating inflammatory, respiratory, gastrointestinal, neurological, and metabolic disorders, but few antagonists are known.
Barry, Grant D., Cotterell, Adam J., Fairlie, David P., Jiang, Yuhong, Lim, Junxian, Liu, Ligong, Lohman, Rink-Jan, Mak, Jeffrey Y. W., Reid, Robert C., Suen, Jacky Y., Vesey, David A., Yau, Mei-Kwan   +11 more
core   +2 more sources

1-Methyl-3-p-tolyl-3,3a,4,9b-tetrahydro-1H-chromeno[4,3-c]isoxazole-3a-carbonitrile

Acta Crystallographica Section E, 2011
In the title compound, C19H18N2O2, the dihedral angle between the mean planes of the fused chromeno and isoxazole units is 43.71 (7)°. The isoxazole and pyran rings exhibit envelope and half chair conformations, respectively.
Rajeswari Gangadharan, K. Sethusankar, Gandhi Murugan, Manickam Bakthadoss   +3 more
doaj   +1 more source

4-(4-Fluorophenyl)-2-methyl-3-(1-oxy-4-pyridyl)isoxazol-5(2H)-one

Acta Crystallographica Section E, 2008
The crystal structure of the title compound, C15H11FN2O3, was determined as part of a study on the biological activity of isoxazolone derivatives as p38 mitogen-activated protein kinase (MAPK) inhibitors.
Stefan Laufer, Dieter Schollmeyer, Simona Margutti   +2 more
doaj   +1 more source

2,10-Bis(3-bromophenyl)-3,7,11,15-tetraoxa-8,16-diazatricyclo[12.2.1.16,9]octadeca-1(16),6(18),8,14(17)-tetraene

Acta Crystallographica Section E, 2010
The title compound, C24H20Br2N2O4, is an 18-membered tricycle including two isoxazole rings. The asymmetric unit contains one half of the formula unit; a centre of inversion is located at the centroid of the compound.
Kwang Ha, Sae Byul Park, Young Ju Lee, Hyung Jin Kim   +3 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of (Z)-3-methyl-4-(thiophen-2-ylmethylidene)isoxazol-5(4H)-one

Acta Crystallographica Section E: Crystallographic Communications, 2021
The title compound, C9H7NO2S crystallizes with two independent molecules (A and B) in the asymmetric unit with Z = 8. Both molecules are almost planar with a dihedral angle between the isoxazole and thiophen rings of 3.67 (2)° in molecule A and 10.00 (1)
Rima Laroum, Assia Benouatas, Noudjoud Hamdouni, Wissame Zemamouche, Ali Boudjada, Abdelmadjid Debache   +5 more
doaj   +1 more source

Platelet protective efficacy of 3,4,5 trisubstituted isoxazole analogue by inhibiting ROS-mediated apoptosis and platelet aggregation [PDF]

, 2016
Thrombocytopenia is a major hematological concern in oxidative stress-associated pathologies and chronic clinical disorders, where premature platelet destruction severely affects the normal functioning of thrombosis and hemostasis.
Basappa, ., Girish, Kesturu.S., Hegde, Mahesh., Jagadish, Swamy., NaveenKumar, Somanathapura. K., Paul, Manoj., Rajeev, Narasimhamurthy., Rangappa, Kanchugarakoppal.S., Sadashiva, Marilinganadoddi.P., Sharath Kumar, Kothanahally.S.   +9 more
core   +1 more source

Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands [PDF]

, 2018
Ferrocene analogues of known fatty acid amide hydrolase inhibitors and CB2 ligands have been synthesized and characterized spectroscopically and crystallographically.
Barczyk, Amélie, Bollier, Mélanie, Coles, Simon J, Dezitter, Xavier, Farce, Amaury, Klupsch, Fredérique, Leleu-Chavain, Natascha, Millet, Regis, Sansook, Supojjanee, Spencer, John, Tizzard, Graham J, Tuo, Wei   +11 more
core   +2 more sources

4-(4-Chlorophenyl)-5-phenylisoxazole

Acta Crystallographica Section E, 2009
The title compound, C15H10ClNO, is a functionalized isoxazole with a chlorophenyl and a phenyl substitutent. The mean plane of the isoxazole ring is inclined to those of the two benzene ring mean planes by 38.32 (16) and 43.91 (18 ...
M. Krishnaiah, R. Ravi Kumar, Thanzaw Oo, Pho Kaung   +3 more
doaj   +1 more source

Synthesis of Some Novel Heterocyclic and Schiff Base Derivatives as Antimicrobial Agents

Molecules, 2015
Treatment of 2,3-diaryloxirane-2,3-dicarbonitriles 1a–c with different nitrogen nucleophiles, e.g., hydrazine, methyl hydrazine, phenyl hydrazine, hydroxylamine, thiosemicarbazide, and/or 2-amino-5-phenyl-1,3,4-thiadiazole, afforded pyrazole, isoxazole ...
Mohamed E. Azab, Sameh A. Rizk, Abd El-Galil E. Amr   +2 more
doaj   +1 more source

Symmetric 3,5-Pyrazole and Isoxazole Heterocycles Comprising a Bent Core Unit: Synthesis and Mesomorphic Characterisation [PDF]

, 2015
The synthesis and characterisation of some new liquid crystalline (LC) heteroaromatic compounds containing the five-membered pyrazole/isoxazole rings is reported. Some of the compounds exhibited enantiotropic LC properties.
Hariprasad, S., Srinivasa, H.T.
core   +1 more source