Results 61 to 70 of about 24,568 (261)

Heroin-piracetam mixture: suggested mechanisms of action and risks of misinterpretation for drug users [PDF]

, 2017
Piracetam is a positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that has been frequently used in the treatment of cognitive disorders.
Cappelletti, Simone, Ciallella, Costantino, Lombardo, Francesco, Vallone, Giuseppe, Vitale, Pasquale   +4 more
core   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Accepted Article.
Over the past decades extensive scientific research in the fields of chemistry and pharmaceutical chemistry has led to the synthesis and study of numerous chemical compounds with diverse therapeutic applications. Many of these compounds feature heterocyclic aromatic structures, including six‐, five‐, and four‐membered rings.
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Studies on Oxasteroids. I. Synthesis of 3-Cyano-3-methylchroman-4-one. [PDF]

, 1968
Condensation of chroman-4-one with ethyl formate in the presence of sodium methoxide gave 3-hydroxymethylenechroman-4-one (II). Reaction of II with hydroxylamine hydrochloride, followed isomerization by potassium t-butoxide gave IV.
Honjo, Yozo, Moriwake, Tosio
core   +1 more source

Microtracer‐Based Assessment of the Mass Balance, Pharmacokinetics, and Excretion of [14C]Berzosertib, an Intravenous ATR Inhibitor, in Patients With Advanced Solid Tumors: A Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Berzosertib is a small‐molecule ataxia telangiectasia and Rad3‐related protein inhibitor. To assess the clearance mechanism(s) of berzosertib, a Phase 1, 2‐period, open‐label study was conducted in adults with advanced solid tumors who were treated with a single intravenous dose of 210 mg/m2 berzosertib containing approximately 3 µCi of [14C ...
Jayaprakasam Bolleddula, Holger Scheible, Florian Huber, Annick Seithel‐Keuth, Hanno Schieferstein, Deepthi S. Vagge, Nadra Mammasse, Eva Jaks, Jordi Ferrer, Camilo Moulin, Jennifer Dong, Karthik Venkatakrishnan, Zsuzsanna Papai   +12 more
wiley   +1 more source

A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes [PDF]

, 2014
Novel drugs are required for the elimination of infections caused by filarial worms, as most commonly used drugs largely target the microfilariae or first stage larvae of these infections.
AL Petersen, B Dembele, BM Bronsvoort, C Bourguinat, C Bourguinat, Charles D. Mackenzie, D Shahinas, D Wenkert, E Devaney, E Devaney, E Devaney, EB Garon, Eileen Devaney, Francis M. Sverdrup, G Chiosis, HK Choi, JC Pizarro, JE Allen, K Jhaveri, Kerry O'Neill, Kirsty Maitland, L Neckers, L Neckers, LC Cerchietti, LH Pearl, MA Felix, MG Basanez, MJ Taylor, PA Brough, R Kumar, R Pallavi, RE Howells, RM Jecock, S Subramanian, SA Eccles, SA Robertson, T Kim, T Taldone, T Taldone, T Taldone, TG Geary, TY Lin, V Gillan, Victoria Gillan, WF Schafer, X Lu, Y Du   +46 more
core   +2 more sources

1-(3-p-Tolylisoxazol-5-yl)cyclohexanol

Acta Crystallographica Section E, 2009
The title compound, C16H19NO2, contains two molecules in the asymmetric unit. Each molecule is composed of three interconnected rings, two essentially planar rings, viz.
Lahcen El Ammari, Mohamed Soufiaoui, Rachid Benhida, Khalid Bougrin, Ouafaa Khalil   +4 more
doaj   +1 more source

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

Medicinal Research Reviews, EarlyView.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra, Zoltán Mucsi, Janez Ilaš, Petra Dunkel   +3 more
wiley   +1 more source

3-Benzyl-5-methyl-1,2-benzoxazole 2-oxide

Acta Crystallographica Section E, 2012
In the title compound, C15H13NO2, the isoxazole unit and the attached benzene ring are almost coplanar, making a dihedral angle of 1.42 (8)°.
G. Anuradha, Vasuki Gopalsamy, A. Veera Reddy, G. Laxminarasimhulu   +3 more
doaj   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

One-step synthesis of differently bis-functionalized isoxazoles by cycloaddition of carbamoylnitrile oxide with β-keto esters [PDF]

, 2012
A new protocol for synthesizing different functionalized isoxazoles is provided. Carbamoylnitrile oxide generated from nitroisoxazolone underwent inverse electron-demand 1,3-dipolar cycloaddition with 1,3-dicarbonyl compounds in the presence of magnesium
975, 976, 977, 978, 979, 980, 981, 982, Ariga, Masahiro, Hirao, Shotaro, Ise, Yumiko, Kobiro, Kazuya, Nishiwaki, Nagatoshi, Nishizawa, Maho, Saigo, Kazuhiko, Sawayama, Jun   +15 more
core   +1 more source