Results 61 to 70 of about 32,281 (298)

Side-chain Modifications of Highly Functionalized 3(2H)-Furanones

Molecules, 2012
A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives.
Gil Valdo José da Silva, Maurício Gomes Constantino, Viviani Nardini, Shirley Muniz Machado Rodrigues   +3 more
doaj   +1 more source

2‐Aminoindoles and 2‐Iminoindolines as Viable Precursors of Indole‐Fused Nitrogenated Polyheterocycles

Advanced Synthesis &Catalysis, Volume 367, Issue 6, March 18, 2025.
Abstract The synthesis of architecturally complex polyheterocyclic structures embedding the indole ring represents a growing field of interest. Carbolines and their partially dehydro derivatives, pyrazinoindoles, indoloindoles, azepinoindoles and other medium‐sized derivatives are only some examples of indole‐containing polycyclic compounds featured by
Alessandro Palmieri, Marino Petrini
wiley   +1 more source

Synthesis and biological evaluation of (3-arylisoxazol-5-yl) methyl 6-fluoro-4-oxo-4H-chromene-2-carboxylates as antioxidant and antimicrobial agents [PDF]

Journal of the Serbian Chemical Society, 2017
A series of novel (3-aryl-1,2-oxazol-5-yl) methyl 6-fluoro-4-oxo-4H- -chromene-2-carboxylate derivatives (C1-C12) were synthesized by Cu (I) catalyzed reaction of in situ generated nitrile oxides with prop-2-yn-1-yl 6-fluoro-4-oxo-4H-chromene-2 ...
Battula Kumaraswamy, Narsimha Sirassu, Nagavelli Vasudeva Reddy, Srinivasa Rao Mutheneni   +3 more
doaj   +1 more source

An anomalous hydration/dehydration sequence for the mild generation of a nitrile oxide [PDF]

, 2011
A nitrile oxide containing a carbamoyl group is readily generated upon the treatment of 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with water under mild reaction conditions, even in the absence of special reagents.
884, 885, 886, 887, 888, 889, 890, 891, 892, 893, Ariga, Masahiro, Hirao, Shotaro, Kiyoto, Hideyuki, Kobiro, Kazuya, Maki, Asaka, Nishiwaki, Nagatoshi, Okajima, Yoshikazu, Saigo, Kazuhiko, Sawayama, Jun, Uehara, Toshiharu   +19 more
core   +2 more sources

SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease

Advanced Science, Volume 12, Issue 17, May 8, 2025.
SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi, Kai Tao, Xiaomin Wen, Dayun Feng, Zifan Mai, Hui Ding, Honghui Mao, Mingming Wang, Qian Yang, Jie Xiang, Jie Zhang, Shengxi Wu   +11 more
wiley   +1 more source

A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor

Molecules, 2021
A convenient synthetic approach to novel functionalized bis(isoxazoles), the promising bivalent ligands of the AMPA receptor, was elaborated.
Dmitry A. Vasilenko, Kirill S. Sadovnikov, Kseniya N. Sedenkova, Dmitry S. Karlov, Eugene V. Radchenko, Yuri K. Grishin, Victor B. Rybakov, Tamara S. Kuznetsova, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Vladimir A. Palyulin, Elena B. Averina   +11 more
doaj   +1 more source

Bioactivation of isoxazole-containing bromodomain and extra-terminal domain (BET) inhibitors [PDF]

, 2021
The 3,5-dimethylisoxazole motif has become a useful and popular acetyl-lysine mimic employed in isoxazole-containing bromodomain and extra-terminal (BET) inhibitors but may introduce the potential for bioactivations into toxic reactive metabolites.
Boysen, Gunnar, Conway, Stuart J, Farmer, Rohit, Flynn, Noah R, Laurin, Corentine M C, Miller, Grover P, Schleiff, Mary A, Swamidass, S Joshua, Ward, Michael D   +8 more
core   +2 more sources

Supramolecular Polymerization and Functions of Isoxazole Ring Monomers

, 2020
Head-to-tail dipole-dipole arrays of isoxazole rings lead to supramolecular helical assemblies where the assembly and disassembly are regulable based on temperature and solvent properties.
T. Haino, Takehiro Hirao
semanticscholar   +1 more source

GLS1‐Mediated Redundancy in Glutamate Accelerates Arterial Calcification via Activating NMDAR/Ca2+/β‐Catenin Pathway

Advanced Science, EarlyView.
GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou, Bing Dong, Dayu He, Jianshuai Ma, Yun Kong, Huijin Zhu, Chen Xie, Tiecheng Yang, Xin Zhen, Zhengzhipeng Zhang, Zhaohui He, Jinkun Cheng, Aoran Huang, Jie Chen, Ruo Wu, Huiyong Yin, Yanlian Chen, Jun Tao, Hui Huang   +18 more
wiley   +1 more source

Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands [PDF]

, 2018
Ferrocene analogues of known fatty acid amide hydrolase inhibitors and CB2 ligands have been synthesized and characterized spectroscopically and crystallographically.
Barczyk, Amélie, Bollier, Mélanie, Coles, Simon J, Dezitter, Xavier, Farce, Amaury, Klupsch, Fredérique, Leleu-Chavain, Natascha, Millet, Regis, Sansook, Supojjanee, Spencer, John, Tizzard, Graham J, Tuo, Wei   +11 more
core   +2 more sources