Results 71 to 80 of about 32,281 (298)

Synthesis, chemo-informatics, and anticancer evaluation of fluorophenyl-isoxazole derivatives

Open Chemistry, 2021
The current study aimed to design and synthesize a novel series of fluorophenyl-isoxazole-carboxamide derivatives and evaluate their antiproliferative activities.
Hawash Mohammed, Jaradat Nidal, Abualhasan Murad, Amer Johnny, Levent Serkan, Issa Shahd, Ibrahim Sameeha, Ayaseh Aseel, Shtayeh Tahrir, Mousa Ahmed   +9 more
doaj   +1 more source

Synthesis, Physicochemical Characteristics and Plausible Mechanism of Action of an Immunosuppressive Isoxazolo[5,4-e]-1,2,4-Triazepine Derivative (RM33)

Pharmaceuticals, 2021
Previous studies demonstrated strong anti-inflammatory properties of isoxazolo[5,4-e]-1,2,4-triazepine (RM33) in vivo. The aim of this investigation was to describe synthesis, determine physicochemical characteristics, evaluate biological activities in ...
Marcin Mączyński, Andrzej Regiec, Aleksandra Sochacka-Ćwikła, Iwona Kochanowska, Maja Kocięba, Ewa Zaczyńska, Jolanta Artym, Wojciech Kałas, Michał Zimecki   +8 more
doaj   +1 more source

One-step synthesis of differently bis-functionalized isoxazoles by cycloaddition of carbamoylnitrile oxide with β-keto esters [PDF]

, 2012
A new protocol for synthesizing different functionalized isoxazoles is provided. Carbamoylnitrile oxide generated from nitroisoxazolone underwent inverse electron-demand 1,3-dipolar cycloaddition with 1,3-dicarbonyl compounds in the presence of magnesium
975, 976, 977, 978, 979, 980, 981, 982, Ariga, Masahiro, Hirao, Shotaro, Ise, Yumiko, Kobiro, Kazuya, Nishiwaki, Nagatoshi, Nishizawa, Maho, Saigo, Kazuhiko, Sawayama, Jun   +15 more
core   +1 more source

Analgesic Activity of Some 1,2,4-Triazole Heterocycles Clubbed with Pyrazole, Tetrazole, Isoxazole and Pyrimidine [PDF]

, 2013
Purpose: In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine ring have been evaluated.
Appala Raju, Popat Baban Mohite, Ramdas Bhanudas Pandhare, Shantaram Gajanan Khanage   +3 more
core   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Conjugation at the oligonucleotide level based on isoxazole phosphoramidites generated by click chemistry [PDF]

, 2011
The versatility of the isoxazole generating nitrile oxide–alkyne Huisgen cycloaddition for provision of chemically modified oligonucleotides has been extended; in a novel approach isoxazole conjugated oligodeoxyribonucleotides have been constructed by ...
Freeman, Colin, Heaney, Frances, Ni Cheallaigh, Aisling   +2 more
core  

4-tert-Butyl-4′-(4-meth­oxy­phen­yl)-3′-(4-methyl­phen­yl)-1,2,3,4-tetra­hydro­spiro­[naphthalene-2,5′(4′H)-1,2-oxazol]-1-one [PDF]

, 2010
In the title compound, C30H31NO3, the tolyl ring is almost coplanar with the isoxazole ring [dihedral angle = 12.51 (7)°], whereas the meth­oxy­phenyl ring is almost perpendicular to the isoxazole ring [dihedral angle = 89.77 (5)°].
Akhazzane, Mohamed, Al Houari, Ghali, Daoudi, Maria, Kerbal, Abdelali, Zouihri, Hafid   +4 more
core   +3 more sources

Derivatizing immobilization methods for TEMPO radicals in metal–organic frameworks: Toward efficient aerobic oxidation and sequential reactions

Bulletin of the Korean Chemical Society, EarlyView.
Covalent attachment of TEMPO radicals to Zr‐based metal–organic frameworks (MOFs) was achieved by diversifying linker structures, enabling efficient aerobic oxidation of secondary alcohols. The modified MOFs facilitated sequential reactions, including isoxazole synthesis via aerobic oxidation and cycloaddition, demonstrating their versatility and ...
Seungheon Cha, Daeyeon Lee, Jiwon Kang, Jonghyeon Lee, Seongwoo Kim, Houng Kang, Soyoung Park, Min Kim   +7 more
wiley   +1 more source

Methyl 3-phenylisoxazole-5-carboxylate

Acta Crystallographica Section E, 2014
In the title compound, C11H9NO3, the dihedral angle between the isoxazole and phenyl rings is 19.79 (12), while the ester group is inclined to the isoxazole group by 12.14 (6)°.
Li Wang, Ya-jun Li, Yao-dong Li, Wei Zhang, Rui Xu   +4 more
doaj   +1 more source

Synthesis of 3,5-Disubstituted Isoxazoles and Isoxazolines in Deep Eutectic Solvents [PDF]

, 2015
The synthesis of different 3,5-disubstituted isoxazoles and related isoxazolines using choline chloride:urea as deep eutectic solvent (DES) in a one-pot three step reaction has been accomplished successfully. The use of highly nucleophilic functionalized
Pérez Galera, Juana María, Ramón, Diego J.   +1 more
core   +3 more sources