Results 101 to 110 of about 19,238 (306)

Selective [5 + 1] and [5 + 2] Cycloaddition of Ynamides or Propargyl Esters with Benzo[ d]isoxazoles via Gold Catalysis.

open access: yesJournal of Organic Chemistry, 2018
Benzo[ d]isoxazoles are found to act as novel nucleophiles to undergo gold-catalyzed [5 + 1] or [5 + 2] cycloaddition reactions with ynamides. The reaction provides a concise and chemoselective access to polysubstituted 2 H-benzo[ e][1,3]oxazines or ...
W. Xu   +3 more
semanticscholar   +1 more source

The Targets of Deep Brain Stimulation in the Treatment of Treatment‐Resistant Depression: A Review

open access: yesBrain and Behavior, Volume 15, Issue 5, May 2025.
Schematic Representation of the DBS Procedure for the Management of TRD. The DBS electrode is electrically stimulated by a long lead. Potential mechanisms of action are presented below. The right side highlights the key summary of the article. ABSTRACT Purpose The purpose of this review is to evaluate the current state and potential future directions ...
Jianyang Dong   +5 more
wiley   +1 more source

Studies on Bioactive Heterocycles [PDF]

open access: yes, 2010
Not ...
Savant, Mahesh M.
core  

Palladium-Catalyzed Cascade Annulation/Allylation of Alkynyl Oxime Ethers with Allyl Halides: Rapid Access to Fully Substituted Isoxazoles.

open access: yesJournal of Organic Chemistry, 2019
A novel and efficient approach for the synthesis of functionalized isoxazoles via palladium-catalyzed cascade annulation/allylation of alkynyl oxime ethers with allyl halides has been established.
Can Li   +4 more
semanticscholar   +1 more source

Deficiency of the Synaptic Adhesion Protein Leucine‐Rich Repeat Transmembrane Protein 4 Like 1 Affects Anxiety and Aggression in Zebrafish

open access: yesActa Physiologica, Volume 241, Issue 5, May 2025.
ABSTRACT Aim Leucine‐rich repeat transmembrane proteins (LRRTMs) are synaptic adhesion proteins that regulate synapse development and function. They interact transsynaptically with presynaptic binding partners to promote presynaptic differentiation. Polymorphisms of LRRTM4, one of the four members of this protein family, have been linked to multiple ...
Eva Tatzl   +7 more
wiley   +1 more source

Antimicrobial Evaluation of Dichloro Chromene Isoxazoles and Isoxazoline Derivatives [PDF]

open access: yes, 2019
In the present study, the synthesized benzopyran isoxazolines and isoxazoles were evaluated for antibacterial activity by Agar well diffusion method against multi drug resistance (MDR) clinical isolates of five bacterial strains.i.e., Staphylococcus sp. (
Ghosal, Sabari   +4 more
core   +1 more source

Evaluation on the Effect of Mechanical Stress in Pericyclic Reactions: Mechanochemical Enabled 1,3-Dipolar Cycloaddition Between Nitrile Oxides and Alkynes [PDF]

open access: yes, 2023
The synthesis of heterocycles has constituted a proliferating and growing area in chemistry. Among these, isoxazole motifs are commonly found in many drug candidates, novel materials, and versatile intermediates used to synthesize complex natural ...
Hernandez R., Rafael A.
core  

Synthesis and Biological Evaluation of Some New Pyridines, Isoxazoles and Isoxazolopyridazines Bearing 1,2,3-Triazole Moiety

open access: yesActa Poloniae Pharmaceutica - Drug Research, 2019
: Some new isoxazole derivatives 3a-d were synthesized via the reaction of 3-(dimethylamino)-1-(5- methyl-1-(3-nitrophenyl)-1 H -1,2,3-triazol-4-yl)prop-2-en-1-one ( 1 ) with different hydroximoyl chloride derivatives 2a-d .
Anhar Hassan   +3 more
semanticscholar   +1 more source

Clinical, Electroencephalogram and Imaging Characteristics of Patients With Anti‐LGI1 Antibody Encephalitis: A Multicenter Cohort Study

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 5, May 2025.
To summarize and analyze the general clinical manifestations, laboratory tests, electroencephalography and imaging characteristics, treatment and prognosis of 88 patients with anti‐leucine‐rich glioma inactivated protein 1 antibody encephalitis (LGI1‐AE) at baseline, discharge, and follow‐up in China, aiming to identify risk factors affecting disease ...
Yang Zhao   +13 more
wiley   +1 more source

Synthesis of highly substituted allenylsilanes by alkylidenation of silylketenes [PDF]

open access: yes, 2005
BACKGROUND: Allenylsilanes are useful intermediates in organic synthesis. An attractive, convergent but little used approach for their synthesis is the alkylidenation of stable silylketenes.
Ducept, P.C., Marsden, S.P.
core   +3 more sources

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