Results 101 to 110 of about 19,561 (308)

Effects of perampanel on bone health in adult patients with epilepsy

Epilepsia Open, Volume 10, Issue 3, Page 822-830, June 2025.
Abstract Objective The objective was to assess the effects of perampanel (PER) on bone metabolism and bone mineral density (BMD) in adult patients with epilepsy. Methods This retrospective study included consecutive patients admitted to the Epilepsy Center of Sichuan Provincial People's Hospital from January 2023 to June 2024.
Mingxing Yu, Nana Zhang, Chunyan Chen, Yuxuan He, Jing Meng, Wen Luo, Yi Liang, Yi Guo, Liang Yu   +8 more
wiley   +1 more source

Estimation and Validation of an Effective Ergothioneine Dose for Improved Sleep Quality Using Physiologically Based Pharmacokinetic Model

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
We proposed a new approach to estimate the minimum efficacious doses of a food ingredient using a PBPK model. The study was conducted in two parts: Study 1 involved the optimization of the PBPK model based on plasma and blood EGT concentration profiles.
Hitoshi Okumura, Yudai Araragi, Kentaro Nishioka, Reiya Yamashita, Toshihide Suzuki, Hiroshi Watanabe, Yukio Kato, Norihito Murayama   +7 more
wiley   +1 more source

Contrasts among origins of corn hybrids in relation to their susceptibility to nicosulfuron and isoxaflutole herbicides
Contrastes entre procedências de híbridos de milho em relação à suscetibilidade aos herbicidas nicosulfuron e isoxaflutole

Semina: Ciências Agrárias, 2010
Herbicide selectivity is the basis for successfull weed chemical control in agricultural production, as it is considered as a measurement of the difeerential response of different plant species to a certain herbicide.
Rosecler Salete Canossa, João Guilherme Zanetti de Arantes, Diego Gonçalves Alonso, Denis Fernando Biffe, Jamil Constantin, Rubem Silvério de Oliveira Junior, Sidnei Douglas Cavalieri   +6 more
doaj   +1 more source

Selective [5 + 1] and [5 + 2] Cycloaddition of Ynamides or Propargyl Esters with Benzo[ d]isoxazoles via Gold Catalysis.

Journal of Organic Chemistry, 2018
Benzo[ d]isoxazoles are found to act as novel nucleophiles to undergo gold-catalyzed [5 + 1] or [5 + 2] cycloaddition reactions with ynamides. The reaction provides a concise and chemoselective access to polysubstituted 2 H-benzo[ e][1,3]oxazines or ...
W. Xu, Jidong Zhao, Xiangdong Li, Yuanhong Liu   +3 more
semanticscholar   +1 more source

Targeting KRAS in Cancer Therapy: Beyond Inhibitors

MedComm, Volume 6, Issue 7, July 2025.
Chunhui Chen, Zhiqiang Peng, Lingqiang Zhang   +2 more
wiley   +1 more source

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, Volume 292, Issue 11, Page 2865-2881, June 2025.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source

Palladium-Catalyzed Cascade Annulation/Allylation of Alkynyl Oxime Ethers with Allyl Halides: Rapid Access to Fully Substituted Isoxazoles.

Journal of Organic Chemistry, 2019
A novel and efficient approach for the synthesis of functionalized isoxazoles via palladium-catalyzed cascade annulation/allylation of alkynyl oxime ethers with allyl halides has been established.
Can Li, Jianxiao Li, F. Zhou, Chao-An Li, Wanqing Wu   +4 more
semanticscholar   +1 more source

Hippocampal‐Specific Insulin Resistance Elicits Synaptic Effects on Glutamate Neurotransmission

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
In animals with hippocampal‐specific insulin resistance, reduced vGluT2 and synaptophysin expression resulted in lowered synaptic glutamate concentrations. These animals also exhibited reduced serine phosphorylation of GluA1 (green postsynaptic receptor) and reduced expression of GluN2B (purple postsynaptic receptor).
Jennifer M. Erichsen, Jennifer L. Woodruff, Claudia A. Grillo, Gerardo G. Piroli, Jim R. Fadel, Lawrence P. Reagan   +5 more
wiley   +1 more source

Acute Effects of Four Major Trace Amines on Zebrafish Behavioral, Neurochemical, and Neuroendocrine Responses

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
A trace amine beta‐phenylethylamine is anxiolytic and reduces brain acetylcholine at 12 μg/L, but elevates anxiety and cortisol levels at 1000 μg/L. Acute tryptamine at 7 mg/L is anxiogenic, reduces shoaling and social interaction, but elevates brain acetylcholine and cortisol levels. Acute tyramine at 15 μg/L, and octopamine at 125, 500, and 1500 μg/L,
Thalia M. Quintanilha, Pietra M. Costa, Ana L. S. Cardoso, Gabrieli S. Battú, Leonardo M. Bastos, Bruno P. dos Santos, Talise E. Müller, Tiago F. de Oliveira, Angelo Piato, Allan V. Kalueff, Murilo S. de Abreu   +10 more
wiley   +1 more source

Aplicação de α-oxoceteno ditiocetais em síntese orgânica Reactivity of α-oxoketene dithiocetals in organic synthesis

Química Nova, 2010
The synthesis and reactivity of α-oxoketenes dithioacetals (S,S-acetals), general structure [(R¹C=OC(R²)=C(SR³)(SR4)], are reported. We also showed the application of S,S acetals as synthons for efficient synthesis of isoxazoles, pyrazoles ...
Geonir M. Siqueira, Patrícia D. Neuenfeldt, Anaí Duarte, Lizandra C. Bretanha, Rogério A. Freitag, Wilson Cunico   +5 more
doaj   +1 more source