Results 31 to 40 of about 5,165 (157)

Novel Quinazolinone–Isoxazoline Hybrids: Synthesis, Spectroscopic Characterization, and DFT Mechanistic Study

Chemistry, 2022
Quinazolinone and isoxazoline systems have attracted much attention due to their interesting pharmacological properties. The association of these two pharmacophores in a single hybrid structure can boost the biological activity or bring a new one ...
Yassine Rhazi, Mohammed Chalkha, Asmae Nakkabi, Imad Hammoudan, Mohamed Akhazzane, Mohamed Bakhouch, Samir Chtita, Mohamed El Yazidi   +7 more
doaj   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Synthesis and Pharmacological Significance of Isoxazoline Derivatives: A Mini review

Academic Science Journal
Five-membered heterocycles, like isoxazolines, are an important class of compounds of bioorganic and pharmacological importance. They have been treated as useful intermediates for the transformation of a large number of bioactive molecules.
mohammed alwan
doaj   +1 more source

Estimated seroprevalence of Ehrlichia canis in dogs in a remote community in the Northern Territory, Australia

Australian Veterinary Journal, EarlyView.
Background The emergence of Ehrlichia canis in northern Australia in 2020 has reshaped the landscape of tick‐borne diseases in dogs, particularly in rural and remote communities where the brown dog tick (Rhipicephalus linnaei) is endemic. Despite the rapid spread of ehrlichiosis and reported impacts on dog health, its prevalence remains poorly ...
E Shepherdson, K Doust, JH Hoopes, AD Barbosa, J McNeill   +4 more
wiley   +1 more source

A study on selective transformation of norbornadiene into fluorinated cyclopentane-fused isoxazolines

Beilstein Journal of Organic Chemistry, 2021
This work presents an examination of the selective functionalization of norbornadiene through nitrile oxide 1,3-dipolar cycloaddition/ring-opening metathesis (ROM)/cross-metathesis (CM) protocols. Functionalization of commercially available norbornadiene
Zsanett Benke, Attila M. Remete, Loránd Kiss   +2 more
doaj   +1 more source

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl, Mies Bethäuser, Daniela Nürnberger, Stefan Oswald, Andreas Moritz, Melanie Hamann, Joachim Geyer   +6 more
wiley   +1 more source

A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime

Beilstein Journal of Organic Chemistry, 2013
Functionalized 3-trifluoromethyl-2-isoxazolines and 3-trifluoromethylisoxazoles were easily prepared from trifluoromethyl aldoxime 2 under mild conditions by using DIB as oxidant.
Raoni S. B. Gonçalves, Michael Dos Santos, Guillaume Bernadat, Danièle Bonnet-Delpon, Benoit Crousse   +4 more
doaj   +1 more source

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, EarlyView.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source

Randomised, Double‐Blinded, Placebo‐Controlled Challenge Test With Single Food Items in Dogs With Atopic Dermatitis and Adverse Food Reactions

Veterinary Dermatology, EarlyView.
ABSTRACT Background Identification of offending foods in dogs with adverse food reactions is usually based on “deterioration” during open food challenges. Objectives To examine the placebo effect during double‐blinded, placebo‐controlled food challenges using a predefined set of criteria for relapse.
Evi I. Sofou, Elisa Samuel, Svetlina Aleksandrova, Manolis Chatzis, Manolis N. Saridomichelakis   +4 more
wiley   +1 more source

Synthesis and Characterization of Some Amides Containing Isoxazoline Ring

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
This work involves synthesis of amides containing isoxazoline unit starting with chalcone; 4-[3-(3‾-nitrophenyl)-2-propene- 1-one]-aniline[I]. 4-Aminoacetophenone was reacted with 3-nitrobenzaldehyde in basic medium giving chalcone [I] by claisen ...
Kh. F. Ali, Dh. F Hussein, J. H. Tomma
doaj